Mostrar el registro sencillo del ítem

dc.contributor.authorRojas-Cabañeros, Jose Maria 
dc.contributor.authorOliva-Martinez, Jose Luis 
dc.contributor.authorSantos, Eugenio
dc.date.accessioned2019-01-11T15:31:49Z
dc.date.available2019-01-11T15:31:49Z
dc.date.issued2011-03
dc.identifier.citationGenes Cancer. 2011;2(3):298-305es_ES
dc.identifier.issn1947-6019es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/7002
dc.description.abstractThe Son of Sevenless (Sos) factors were originally discovered 2 decades ago as specialized Ras activators in signaling pathways controlling the process of R7 cell development in the eye of Drosophila melanogaster. The 2 known members of the mammalian Sos family (Sos1 and Sos2) code for ubiquitously expressed, highly homologous (69% overall) proteins involved in coupling signals originated by cell surface receptor tyrosine kinases (RTKs) to downstream, Ras-dependent mitogenic signaling pathways. Mechanistically, the Sos proteins function as enzymatic factors interacting with Ras proteins in response to upstream stimuli to promote guanine nucleotide exchange (GDP/GTP) and subsequent formation of the active Ras-GTP complex. In this review, we summarize current knowledge on structural, regulatory, and functional aspects of the Sos family, focusing on specific aspects of Sos biology such as structure-function relationship, crosstalk with different signaling pathways, and in vivo functional significance as deduced from phenotypic characterization of Sos knockout mice and human genetic syndromes caused by germline hSos1 mutations.es_ES
dc.description.sponsorshipThis work was supported by the Fondo de Investigación Sanitaria [grant numbers PI09/0562 (J.M.R.), PI10/00815 (J.L.O.), PS09/01979 (E.S.)]; Red Temática de Investigación Cooperativa en Cáncer [grant numbers RD06/0020/0003 (J.M.R.), RD06/0020/000 (E.S.)]; Asociación Española Contra el Cáncer (J.M.R.); and Junta de Castilla y León [grant numbers SA044A08, GR93 (E.S.)].es_ES
dc.language.isoenges_ES
dc.publisherImpact Journals es_ES
dc.type.hasVersionVoRes_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectRTKes_ES
dc.subjectRases_ES
dc.subjectRas-GEFes_ES
dc.subjectSoses_ES
dc.subjectsignalinges_ES
dc.titleMammalian son of sevenless Guanine nucleotide exchange factors: old concepts and new perspectiveses_ES
dc.typejournal articlees_ES
dc.rights.licenseAtribución-4.0 Internacional*
dc.identifier.pubmedID21779500es_ES
dc.format.volume2es_ES
dc.format.number3es_ES
dc.format.page298-305es_ES
dc.identifier.doi10.1177/1947601911408078es_ES
dc.contributor.funderInstituto de Salud Carlos III 
dc.contributor.funderRed Temática de Investigación Cooperativa en Cáncer (RTICC) (España) 
dc.contributor.funderAsociación Española Contra el Cáncer 
dc.contributor.funderJunta de Castilla y León (España) 
dc.description.peerreviewedes_ES
dc.identifier.e-issn1947-6027es_ES
dc.relation.publisherversionhttps://www.doi.org/10.1177/1947601911408078es_ES
dc.identifier.journalGenes & canceres_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI09/0562es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI10/00815es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PS09/01979es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/RD06/0020/0003es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/RD06/0020/000es_ES
dc.rights.accessRightsopen accesses_ES


Ficheros en el ítem

Acceso Abierto
Thumbnail

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem

Atribución-4.0 Internacional
Este Item está sujeto a una licencia Creative Commons: Atribución-4.0 Internacional