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dc.contributor.author | Rojas-Cabañeros, Jose Maria | |
dc.contributor.author | Oliva-Martinez, Jose Luis | |
dc.contributor.author | Santos, Eugenio | |
dc.date.accessioned | 2019-01-11T15:31:49Z | |
dc.date.available | 2019-01-11T15:31:49Z | |
dc.date.issued | 2011-03 | |
dc.identifier.citation | Genes Cancer. 2011;2(3):298-305 | es_ES |
dc.identifier.issn | 1947-6019 | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/7002 | |
dc.description.abstract | The Son of Sevenless (Sos) factors were originally discovered 2 decades ago as specialized Ras activators in signaling pathways controlling the process of R7 cell development in the eye of Drosophila melanogaster. The 2 known members of the mammalian Sos family (Sos1 and Sos2) code for ubiquitously expressed, highly homologous (69% overall) proteins involved in coupling signals originated by cell surface receptor tyrosine kinases (RTKs) to downstream, Ras-dependent mitogenic signaling pathways. Mechanistically, the Sos proteins function as enzymatic factors interacting with Ras proteins in response to upstream stimuli to promote guanine nucleotide exchange (GDP/GTP) and subsequent formation of the active Ras-GTP complex. In this review, we summarize current knowledge on structural, regulatory, and functional aspects of the Sos family, focusing on specific aspects of Sos biology such as structure-function relationship, crosstalk with different signaling pathways, and in vivo functional significance as deduced from phenotypic characterization of Sos knockout mice and human genetic syndromes caused by germline hSos1 mutations. | es_ES |
dc.description.sponsorship | This work was supported by the Fondo de Investigación Sanitaria [grant numbers PI09/0562 (J.M.R.), PI10/00815 (J.L.O.), PS09/01979 (E.S.)]; Red Temática de Investigación Cooperativa en Cáncer [grant numbers RD06/0020/0003 (J.M.R.), RD06/0020/000 (E.S.)]; Asociación Española Contra el Cáncer (J.M.R.); and Junta de Castilla y León [grant numbers SA044A08, GR93 (E.S.)]. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Impact Journals | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | RTK | es_ES |
dc.subject | Ras | es_ES |
dc.subject | Ras-GEF | es_ES |
dc.subject | Sos | es_ES |
dc.subject | signaling | es_ES |
dc.title | Mammalian son of sevenless Guanine nucleotide exchange factors: old concepts and new perspectives | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Atribución-4.0 Internacional | * |
dc.identifier.pubmedID | 21779500 | es_ES |
dc.format.volume | 2 | es_ES |
dc.format.number | 3 | es_ES |
dc.format.page | 298-305 | es_ES |
dc.identifier.doi | 10.1177/1947601911408078 | es_ES |
dc.contributor.funder | Instituto de Salud Carlos III | |
dc.contributor.funder | Red Temática de Investigación Cooperativa en Cáncer (RTICC) (España) | |
dc.contributor.funder | Asociación Española Contra el Cáncer | |
dc.contributor.funder | Junta de Castilla y León (España) | |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 1947-6027 | es_ES |
dc.relation.publisherversion | https://www.doi.org/10.1177/1947601911408078 | es_ES |
dc.identifier.journal | Genes & cancer | es_ES |
dc.repisalud.centro | ISCIII::Centro Nacional de Microbiología | es_ES |
dc.repisalud.institucion | ISCIII | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI09/0562 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI10/00815 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PS09/01979 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/RD06/0020/0003 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/RD06/0020/000 | es_ES |
dc.rights.accessRights | open access | es_ES |