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dc.contributor.author | Camacho, Maria Teresa | |
dc.contributor.author | Outschoorn, I | |
dc.contributor.author | Tellez, A | |
dc.contributor.author | Sequí, J | |
dc.date.accessioned | 2019-01-10T11:04:36Z | |
dc.date.available | 2019-01-10T11:04:36Z | |
dc.date.issued | 2005-11-10 | |
dc.identifier.citation | J Autoimmune Dis. 2005 Nov 10;2:10. | es_ES |
dc.identifier.issn | 17402557 | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/6983 | |
dc.description.abstract | Recent reports have shown that some of the immunological aspects of Q fever, a rickettsiosis caused by Coxiella burnetii, could be related to self-antigen responses. The aim of this study was to determine the specificity of the autoantibody response of patients with acute and chronic Coxiella infections. Smooth muscle and cardiac muscle-specific autoantibodies were observed in significant percentages in acutely or chronically affected Q fever patients when compared to healthy volunteers. Moreover, the incidence of cardiac muscle-specific autoantibody was significantly higher among chronically ill patients compared to acutely ill patients. Moreover, a band of 50 kD of a HeLa extract was detected in most of the sera of individuals with chronic infections and previous sequence analysis suggests that this antigen presents a high degree of homology with the human actin elongation factor 1 alpha. Further research would be necessary to confirm if antibodies to human cytoskeletal proteins could be of clinical importance in chronically infected Q fever patients. | es_ES |
dc.description.sponsorship | This work was supported by a grant from the Fondo de Investigaciones Sanitarias (Expt n° 97/0191). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | BioMed Central (BMC) | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject.mesh | Autoantibodies | es_ES |
dc.subject.mesh | Coxiella burnetii | es_ES |
dc.subject.mesh | Q Fever | es_ES |
dc.title | Autoantibody profiles in the sera of patients with Q fever: characterization of antigens by immunofluorescence, immunoblot and sequence analysis | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Atribución 4.0 Internacional | * |
dc.identifier.pubmedID | 16280092 | es_ES |
dc.format.volume | 2 | es_ES |
dc.format.number | 1 | es_ES |
dc.format.page | 10 | es_ES |
dc.identifier.doi | 10.1186/1740-2557-2-10 | es_ES |
dc.contributor.funder | Instituto de Salud Carlos III | |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 1740-2557 | es_ES |
dc.relation.publisherversion | https://doi.org/10.1186/1740-2557-2-10 | es_ES |
dc.identifier.journal | Journal of autoimmune diseases | es_ES |
dc.repisalud.centro | ISCIII::Centro Nacional de Microbiología | es_ES |
dc.repisalud.institucion | ISCIII | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/97/0191 | es_ES |
dc.rights.accessRights | open access | es_ES |