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dc.contributor.authorCamacho, Maria Teresa 
dc.contributor.authorOutschoorn, I 
dc.contributor.authorTellez, A 
dc.contributor.authorSequí, J
dc.date.accessioned2019-01-10T11:04:36Z
dc.date.available2019-01-10T11:04:36Z
dc.date.issued2005-11-10
dc.identifier.citationJ Autoimmune Dis. 2005 Nov 10;2:10.es_ES
dc.identifier.issn17402557es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/6983
dc.description.abstractRecent reports have shown that some of the immunological aspects of Q fever, a rickettsiosis caused by Coxiella burnetii, could be related to self-antigen responses. The aim of this study was to determine the specificity of the autoantibody response of patients with acute and chronic Coxiella infections. Smooth muscle and cardiac muscle-specific autoantibodies were observed in significant percentages in acutely or chronically affected Q fever patients when compared to healthy volunteers. Moreover, the incidence of cardiac muscle-specific autoantibody was significantly higher among chronically ill patients compared to acutely ill patients. Moreover, a band of 50 kD of a HeLa extract was detected in most of the sera of individuals with chronic infections and previous sequence analysis suggests that this antigen presents a high degree of homology with the human actin elongation factor 1 alpha. Further research would be necessary to confirm if antibodies to human cytoskeletal proteins could be of clinical importance in chronically infected Q fever patients.es_ES
dc.description.sponsorshipThis work was supported by a grant from the Fondo de Investigaciones Sanitarias (Expt n° 97/0191).es_ES
dc.language.isoenges_ES
dc.publisherBioMed Central (BMC) es_ES
dc.type.hasVersionVoRes_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subject.meshAutoantibodies es_ES
dc.subject.meshCoxiella burnetii es_ES
dc.subject.meshQ Fever es_ES
dc.titleAutoantibody profiles in the sera of patients with Q fever: characterization of antigens by immunofluorescence, immunoblot and sequence analysises_ES
dc.typejournal articlees_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID16280092es_ES
dc.format.volume2es_ES
dc.format.number1es_ES
dc.format.page10es_ES
dc.identifier.doi10.1186/1740-2557-2-10es_ES
dc.contributor.funderInstituto de Salud Carlos III 
dc.description.peerreviewedes_ES
dc.identifier.e-issn1740-2557es_ES
dc.relation.publisherversionhttps://doi.org/10.1186/1740-2557-2-10es_ES
dc.identifier.journalJournal of autoimmune diseaseses_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/97/0191es_ES
dc.rights.accessRightsopen accesses_ES


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Atribución 4.0 Internacional
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