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dc.contributor.author | García-García, María Luz | |
dc.contributor.author | Calvo, Cristina | |
dc.contributor.author | Rey, Cristina | |
dc.contributor.author | Díaz, Beatriz | |
dc.contributor.author | Molinero, Mar | |
dc.contributor.author | Pozo Sanchez, Francisco | |
dc.contributor.author | Casas Flecha, Inmaculada | |
dc.date.accessioned | 2018-12-27T10:42:50Z | |
dc.date.available | 2018-12-27T10:42:50Z | |
dc.date.issued | 2017-03-16 | |
dc.identifier.citation | PLoS One. 2017 Mar 16;12(3):e0173504. | es_ES |
dc.identifier.issn | 1932-6203 | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/6958 | |
dc.description.abstract | BACKGROUND: Human metapneumovirus (HMPV) has an important etiological role in acute lower respiratory infections in children under five years. Our objectives were to estimate the relative contribution of HMPV to hospitalization in children with acute respiratory infection, to define the clinical and epidemiological features of HMPV single and multiple infections, and to compare HMPV infections with respiratory syncytial virus (HRSV), rhinovirus (HRV), adenovirus and human bocavirus infections in the same population. METHODS AND FINDINGS: A prospective study performed on all children less than 14 years of age with a respiratory tract disease admitted to a secondary hospital between September 2005- June 2014. Clinical characteristics of patients were analyzed. Nasopharyngeal aspirate was taken at admission for viral study with polymerase chain reaction for 16 respiratory viruses. A total of 3,906 children were included. At least one respiratory virus was detected in 75.2% of them. The most common identified virus was HRSV, followed by HRV. HMPV was detected in 214 cases (5.5%); 133 (62%) were single infections and the remaining were detected in coinfection with other viruses. 90.7% cases were detected between February and May. Children's mean age was 13.83 ± 18 months. Fever was frequent (69%), and bronchiolitis (27%), and recurrent wheezing (63%) were the main clinical diagnosis. Hypoxia was present in 65% of the patients and 47% of them had an infiltrate in X-ray. Only 6 (2.8%) children were admitted to the intensive care unit. Only the duration of the hospitalization was different, being longer in the coinfections group (p <0.05). There were many differences in seasonality and clinical characteristics between HMPV and other respiratory viruses being more similar to HRSV. CONCLUSIONS: HMPV infections accounted for 5.5% of total viral infections in hospitalized children. The clinical characteristics were similar to HRSV infections, but seasonality and clinical data were different from other viral infections. | es_ES |
dc.description.sponsorship | This study has been supported by FIS (Fondo de Investigaciones Sanitarias – Spanish Health Research Fund) grants n°: PI06/0532, PI09/0246, and PI12/0129. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Public Library of Science (PLOS) | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject.mesh | Adolescent | es_ES |
dc.subject.mesh | Child | es_ES |
dc.subject.mesh | Child, Preschool | es_ES |
dc.subject.mesh | Female | es_ES |
dc.subject.mesh | Humans | es_ES |
dc.subject.mesh | Infant | es_ES |
dc.subject.mesh | Male | es_ES |
dc.subject.mesh | Metapneumovirus | es_ES |
dc.subject.mesh | Prospective Studies | es_ES |
dc.subject.mesh | Respiratory Tract Infections | es_ES |
dc.subject.mesh | Spain | es_ES |
dc.subject.mesh | Hospitalization | es_ES |
dc.title | Human metapnuemovirus infections in hospitalized children and comparison with other respiratory viruses. 2005-2014 prospective study | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Atribución 4.0 Internacional | * |
dc.identifier.pubmedID | 28301570 | es_ES |
dc.format.volume | 12 | es_ES |
dc.format.number | 3 | es_ES |
dc.format.page | e0173504 | es_ES |
dc.identifier.doi | 10.1371/journal.pone.0173504 | es_ES |
dc.contributor.funder | Instituto de Salud Carlos III | |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 1932-6203 | es_ES |
dc.relation.publisherversion | https://doi.org/10.1371/journal.pone.0173504 | es_ES |
dc.identifier.journal | PloS one | es_ES |
dc.repisalud.centro | ISCIII::Centro Nacional de Microbiología | es_ES |
dc.repisalud.institucion | ISCIII | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI06/0532 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI09/0246 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI12/0129 | es_ES |
dc.rights.accessRights | open access | es_ES |