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dc.contributor.authorCalvo, Cristina
dc.contributor.authorGarcía-García, María Luz
dc.contributor.authorSanchez-Dehesa, Rosa
dc.contributor.authorRomán, Cristina
dc.contributor.authorTabares, Ana
dc.contributor.authorPozo Sanchez, Francisco 
dc.contributor.authorCasas Flecha, Inmaculada 
dc.date.accessioned2018-12-27T10:30:20Z
dc.date.available2018-12-27T10:30:20Z
dc.date.issued2015-07-06
dc.identifier.citationPLoS One. 2015 Jul 6;10(7):e0132162es_ES
dc.identifier.issn1932-6203es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/6956
dc.description.abstractHuman adenovirus (HAdV) cause upper and lower respiratory tract infections. However, there are few large prospective studies focused on HAdVs acute infections requiring hospitalization. From 2005 to 2013 a prospective study was conducted on children admitted with acute respiratory infections. Specimens of nasopharyngeal aspirate were taken for virological study by PCR and clinical data was recorded. HAdV specimens were genotyped. Frequency and clinical course of HAdV infections were compared with RSV, rhinovirus (RV), human bocavirus (HBoV) and influenza in the same population. HAdV was detected in 403 cases of 2371 confirmed viral infections (17.2%) , of which 154 were single virus infections (38%). We genotyped 154 HAdVs. The most frequent genotypes were HAdV-3 (24%), HAdV-6 (21%), and HAdV-5 (20%). A total of 262 children had fever (64.9%); 194 suffered hypoxia (48%), and 147 presented infiltrate in chest x-rays (36.4%). The most frequent diagnoses were recurrent wheezing or asthma (51.7%), bronchiolitis (18.3 %), and pneumonia (11.9%), and 46 (11.4%) episodes required prolonged hospitalization (>7 days) due to the severity. Adenovirus single infections were compared with single infections of 598 RSV, 494 RV, 83 influenza and 78 HBoV. Significant clinical differences were found between HAdV, RSV and RV infections.es_ES
dc.description.sponsorshipThis study has been supported by FIS (Fondo de Investigaciones Sanitarias – Spanish Health Research Fund) Grants N°: PI06/0532, PS09/0246, and PI12/0129. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.es_ES
dc.language.isoenges_ES
dc.publisherPublic Library of Science (PLOS) es_ES
dc.type.hasVersionVoRes_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subject.meshAdenoviridae es_ES
dc.subject.meshAdenoviridae Infections es_ES
dc.subject.meshAdolescent es_ES
dc.subject.meshChild es_ES
dc.subject.meshChild, Preschool es_ES
dc.subject.meshFemale es_ES
dc.subject.meshHospitalization es_ES
dc.subject.meshHuman bocavirus es_ES
dc.subject.meshHumans es_ES
dc.subject.meshInfant es_ES
dc.subject.meshMale es_ES
dc.subject.meshOrthomyxoviridae es_ES
dc.subject.meshOrthomyxoviridae Infections es_ES
dc.subject.meshParvoviridae Infections es_ES
dc.subject.meshPicornaviridae Infections es_ES
dc.subject.meshRespiratory Syncytial Virus Infections es_ES
dc.subject.meshRespiratory Syncytial Viruses es_ES
dc.subject.meshRetrospective Studies es_ES
dc.subject.meshRhinovirus es_ES
dc.titleEight Year Prospective Study of Adenoviruses Infections in Hospitalized Children. Comparison with Other Respiratory Viruseses_ES
dc.typejournal articlees_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID26147465es_ES
dc.format.volume10es_ES
dc.format.number7es_ES
dc.format.pagee0132162es_ES
dc.identifier.doi10.1371/journal.pone.0132162es_ES
dc.contributor.funderInstituto de Salud Carlos III 
dc.description.peerreviewedes_ES
dc.identifier.e-issn1932-6203es_ES
dc.relation.publisherversionhttps://doi.org/10.1371/journal.pone.0132162es_ES
dc.identifier.journalPloS onees_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI06/0532es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PS09/0246es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI12/0129es_ES
dc.rights.accessRightsopen accesses_ES


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Atribución 4.0 Internacional
Este Item está sujeto a una licencia Creative Commons: Atribución 4.0 Internacional