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dc.contributor.authorEl Moussi, Awatef
dc.contributor.authorPozo Sánchez, Francisco 
dc.contributor.authorBen Hadj Kacem, Mohamed Ali
dc.contributor.authorLedesma, Juan 
dc.contributor.authorCuevas, Maria Teresa 
dc.contributor.authorCasas, Inmaculada 
dc.contributor.authorSlim, Amine
dc.identifier.citationPLoS One. 2013 Sep 19;8(9):e74064es_ES
dc.description.abstractBACKGROUND: The data contribute to a better understanding of the circulation of influenza viruses especially in North-Africa. OBJECTIVE: The objective of this surveillance was to detect severe influenza cases, identify their epidemiological and virological characteristics and assess their impact on the healthcare system. METHOD: We describe in this report the findings of laboratory-based surveillance of human cases of influenza virus and other respiratory viruses' infection during three seasons in Tunisia. RESULTS: The 2008-09 winter influenza season is underway in Tunisia, with co-circulation of influenza A/H3N2 (56.25%), influenza A(H1N1) (32.5%), and a few sporadic influenza B viruses (11.25%). In 2010-11 season the circulating strains are predominantly the 2009 pandemic influenza A(H1N1)pdm09 (70%) and influenza B viruses (22%). And sporadic viruses were sub-typed as A/H3N2 and unsubtyped influenza A, 5% and 3%, respectively. Unlike other countries, highest prevalence of influenza B virus Yamagata-like lineage has been reported in Tunisia (76%) localised into the clade B/Bangladesh/3333/2007. In the pandemic year, influenza A(H1N1)pdm09 predominated over other influenza viruses (95%). Amino acid changes D222G and D222E were detected in the HA gene of A(H1N1)pdm09 virus in two severe cases, one fatal case and one mild case out of 50 influenza A(H1N1)pdm09 viruses studied. The most frequently reported respiratory virus other than influenza in three seasons was RSV (45.29%). CONCLUSION: This article summarises the surveillance and epidemiology of influenza viruses and other respiratory viruses, showing how rapid improvements in influenza surveillance were feasible by connecting the existing structure in the health care system for patient records to electronic surveillance system for reporting ILI cases.es_ES
dc.description.sponsorshipThis research was supported by Unit Virology, Microbiology Laboratory Charles Nicolle's Hospital as National Influenza Centre-Tunis and Influenza and Respiratory Laboratory, Instituto de Salud Carlos III as National Influenza Centre-Madrid. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. It is just an informal statement of the study and the members of the ethic committee of Charles Nicolle's hospital have previously always approved the work of the NICes_ES
dc.publisherPublic Library of Sciencees_ES
dc.relation.isversionofPublisher's versiones_ES
dc.subject.meshGeography, Medical es_ES
dc.subject.meshHemagglutinin Glycoproteins, Influenza Virus es_ES
dc.subject.meshHistory, 21st Century es_ES
dc.subject.meshHumans es_ES
dc.subject.meshInfluenza, Humanes_ES
dc.subject.meshOrthomyxoviridae es_ES
dc.subject.meshPhylogeny es_ES
dc.subject.meshSeasons es_ES
dc.subject.meshSentinel Surveillance es_ES
dc.subject.meshTunisia es_ES
dc.subject.meshPublic Health Surveillance es_ES
dc.titleVirological Surveillance of Influenza Viruses during the 2008-09, 2009-10 and 2010-11 Seasons in Tunisiaes_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.contributor.funderInstituto de Salud Carlos III - ISCIII
dc.contributor.funderTunis National Influenza Centre
dc.identifier.journalPloS onees_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES

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