Please use this identifier to cite or link to this item:http://hdl.handle.net/20.500.12105/6929
Title
HIV-1 Dual Infected LTNP-EC Patients Developed an Unexpected Antibody Cross-Neutralizing Activity
Author(s)
Pernas, Maria ISCIII | Sanchez-Merino, Victor ISCIII | Casado, Concepcion ISCIII | Merino-Mansilla, Alberto ISCIII | Olivares, Isabel ISCIII | Yuste-Herranz, Maria Eloisa ISCIII | Lopez-Galindez, Luis Cecilio ISCIII
Date issued
2015-08-10
Citation
PLoS One. 2015 Aug 10;10(8):e0134054
Language
Inglés
Document type
journal article
Abstract
This study evaluated the neutralization breadth in dually infected (DI) HIV-1 long-term non-progressor elite controller patients (LTNP-EC) using a representative minipanel of 6 viruses from 5 different subtypes. Our results showed an improved neutralization breadth in DI LTNP-EC patients when compared with matched LTNP single-infected patients. The role of viral diversity in neutralization was estimated with the Shannon Entropy and the p-distance in viral quasispecies. We found a positive correlation between neutralization breadth and diversity within the viral quasispecies. This correlation could explain why a group of LTNP-EC patients developed a broad neutralizing response despite having undetectable levels of viremia.
MESH
Antibodies, Neutralizing | Entropy | Follow-Up Studies | Genetic Variation | HIV Antibodies | HIV Infections | HIV-1 | Humans | Neutralization Tests | Phylogeny | Viral Load | Viremia | HIV Long-Term Survivors
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This item is licensed under a: Atribución 4.0 Internacional