Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/6922
Título
Phylodynamics and human-mediated dispersal of a zoonotic virus
Autor(es)
Fecha de publicación
2010-10-28
Cita
PLoS Pathog. 2010 Oct 28;6(10):e1001166
Idioma
Inglés
Tipo de documento
journal article
Resumen
Understanding the role of humans in the dispersal of predominantly animal pathogens is essential for their control. We used newly developed Bayesian phylogeographic methods to unravel the dynamics and determinants of the spread of dog rabies virus (RABV) in North Africa. Each of the countries studied exhibited largely disconnected spatial dynamics with major geopolitical boundaries acting as barriers to gene flow. Road distances proved to be better predictors of the movement of dog RABV than accessibility or raw geographical distance, with occasional long distance and rapid spread within each of these countries. Using simulations that bridge phylodynamics and spatial epidemiology, we demonstrate that the contemporary viral distribution extends beyond that expected for RABV transmission in African dog populations. These results are strongly supportive of human-mediated dispersal, and demonstrate how an integrated phylogeographic approach will turn viral genetic data into a powerful asset for characterizing, predicting, and potentially controlling the spatial spread of pathogens.
MESH
Algeria | Animals | Computer Simulation | Demography | Dogs | Gene Flow | Geography | Humans | Morocco | Rabies virus | Tunisia | Zoonoses | Evolution, Molecular | Phylogeny
Versión en línea
DOI
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