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dc.contributor.authorA-Gonzalez, Noelia 
dc.contributor.authorQuintana, Juan A. 
dc.contributor.authorGarcía-Silva, Susana
dc.contributor.authorMazariegos, Marina
dc.contributor.authorGonzalez de la Aleja, Arturo 
dc.contributor.authorNicolas-Avila, Jose A. 
dc.contributor.authorWalter, Wencke 
dc.contributor.authorAdrover, Jose M 
dc.contributor.authorCrainiciuc, Georgiana 
dc.contributor.authorKuchroo, Vijay K
dc.contributor.authorRothlin, Carla V
dc.contributor.authorPeinado Selgas , Hector 
dc.contributor.authorCastrillo, Antonio
dc.contributor.authorRicote, Mercedes 
dc.contributor.authorHidalgo, Andrés 
dc.date.accessioned2018-12-17T13:18:03Z
dc.date.available2018-12-17T13:18:03Z
dc.date.issued2017-05-01
dc.identifier.citationJ Exp Med. 2017; 214(5):1281-1296es_ES
dc.identifier.issn0022-1007es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/6870
dc.description.abstractTissue-resident macrophages display varying phenotypic and functional properties that are largely specified by their local environment. One of these functions, phagocytosis, mediates the natural disposal of billions of cells, but its mechanisms and consequences within living tissues are poorly defined. Using a parabiosis-based strategy, we identified and isolated macrophages from multiple tissues as they phagocytosed blood-borne cellular material. Phagocytosis was circadianally regulated and mediated by distinct repertoires of receptors, opsonins, and transcription factors in macrophages from each tissue. Although the tissue of residence defined the core signature of macrophages, phagocytosis imprinted a distinct antiinflammatory profile. Phagocytic macrophages expressed CD206, displayed blunted expression of Il1b, and supported tissue homeostasis. Thus, phagocytosis is a source of macrophage heterogeneity that acts together with tissue-derived factors to preserve homeostasis.es_ES
dc.description.sponsorshipThis study was supported by Ministerio de Economia, Competitividad e Industria (MIN ECO) grants SAF2015-65607 and SAF2013-49662-EXP to A. Hidalgo; SVP-2014-068595 to J.A. Nicolás-Ávila; BES-2013–065550 to J.M. Adrover; JCI-2012-12659 to N. A-Gonzalez; and SAF2014-56819-R and SAF2015-71878-REDT to A. Castrillo. Grant CAM S2010/BMD-2350 RAP HYME to A. Castrillo; SAF2015- 64287-R, SAF2015-71878-REDT (MIN ECO), and CardioNext-ITN-608027 (European Commission FP7) to M. Ricote; and R01 AI089824 (National Institutes of Health) to C.V. Rothlin. H.P. is supported by grants from MIN ECO (SAF2014-54541-R), ATR ESMED IA – AXA, Asociación Española Contra el Cáncer, WHRI Academy, and Worldwide Cancer Research. The Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC) is supported by the MIN ECO and the Pro-CNIC Foundation, and is a Severo Ochoa Center of Excellence (MIN ECO award SEV-2015-0505).
dc.language.isoenges_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subject.meshInterleukin-1beta es_ES
dc.subject.meshLectins, C-Type es_ES
dc.subject.meshMacrophages es_ES
dc.subject.meshMale es_ES
dc.subject.meshMannose-Binding Lectins es_ES
dc.subject.meshMice es_ES
dc.subject.meshOpsonin Proteins es_ES
dc.subject.meshPhagocytosis es_ES
dc.subject.meshReceptors, Cell Surfacees_ES
dc.subject.meshTranscription Factors es_ES
dc.titlePhagocytosis imprints heterogeneity in tissue-resident macrophageses_ES
dc.typeArtículoes_ES
dc.rights.licenseAtribución-NoComercial-CompartirIgual 4.0 Internacional*
dc.identifier.pubmedID28432199es_ES
dc.format.volume214es_ES
dc.format.number5es_ES
dc.format.page1281-1296es_ES
dc.identifier.doi10.1084/jem.20161375es_ES
dc.contributor.funderMinisterio de Economía, Competitividad e Industria (España)es_ES
dc.contributor.funderEuropean Commisiones_ES
dc.contributor.funderNational Institutes of Health (United States)es_ES
dc.contributor.funderAtresmedia Corporación de medios de comunicaciónes_ES
dc.contributor.funderAsociación Española Contra el Cánceres_ES
dc.contributor.funderWorldwide Cancer Researches_ES
dc.contributor.funderFundación ProCNICes_ES
dc.description.peerreviewedes_ES
dc.identifier.e-issn1540-9538es_ES
dc.relation.publisherversionJ Exp Med. 2017; 214(5):1281-1296
dc.identifier.journalThe Journal of experimental medicinees_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Imagen de la Inflamación Cardiovascular y la Respuesta Inmunees_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Señalización de los Receptores Nucleareses_ES
dc.repisalud.institucionCNICes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/608027/EUes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SAF2015-65607es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SEV-2015-0505es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SAF2013-49662-EXPes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SVP-2014-068595es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/BES-2013-065550es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/JCI-2012-12659es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SAF2014-56819-Res_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SAF-2015-71878-REDTes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SAF2015-64287-Res_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SAF2014-54541-Res_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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