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dc.contributor.author | Alonso-Gonzalez, Noelia | |
dc.contributor.author | Quintana, Juan A. | |
dc.contributor.author | García-Silva, Susana | |
dc.contributor.author | Mazariegos, Marina | |
dc.contributor.author | Gonzalez de la Aleja, Arturo | |
dc.contributor.author | Nicolas-Avila, Jose A. | |
dc.contributor.author | Walter, Wencke | |
dc.contributor.author | Adrover, Jose M | |
dc.contributor.author | Crainiciuc, Georgiana | |
dc.contributor.author | Kuchroo, Vijay K | |
dc.contributor.author | Rothlin, Carla V | |
dc.contributor.author | Peinado Selgas , Hector | |
dc.contributor.author | Castrillo, Antonio | |
dc.contributor.author | Ricote, Mercedes | |
dc.contributor.author | Hidalgo, Andres | |
dc.date.accessioned | 2018-12-17T13:18:03Z | |
dc.date.available | 2018-12-17T13:18:03Z | |
dc.date.issued | 2017-05-01 | |
dc.identifier.citation | J Exp Med. 2017; 214(5):1281-1296 | es_ES |
dc.identifier.issn | 0022-1007 | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/6870 | |
dc.description.abstract | Tissue-resident macrophages display varying phenotypic and functional properties that are largely specified by their local environment. One of these functions, phagocytosis, mediates the natural disposal of billions of cells, but its mechanisms and consequences within living tissues are poorly defined. Using a parabiosis-based strategy, we identified and isolated macrophages from multiple tissues as they phagocytosed blood-borne cellular material. Phagocytosis was circadianally regulated and mediated by distinct repertoires of receptors, opsonins, and transcription factors in macrophages from each tissue. Although the tissue of residence defined the core signature of macrophages, phagocytosis imprinted a distinct antiinflammatory profile. Phagocytic macrophages expressed CD206, displayed blunted expression of Il1b, and supported tissue homeostasis. Thus, phagocytosis is a source of macrophage heterogeneity that acts together with tissue-derived factors to preserve homeostasis. | es_ES |
dc.description.sponsorship | This study was supported by Ministerio de Economia, Competitividad e Industria (MIN ECO) grants SAF2015-65607 and SAF2013-49662-EXP to A. Hidalgo; SVP-2014-068595 to J.A. Nicolás-Ávila; BES-2013–065550 to J.M. Adrover; JCI-2012-12659 to N. A-Gonzalez; and SAF2014-56819-R and SAF2015-71878-REDT to A. Castrillo. Grant CAM S2010/BMD-2350 RAP HYME to A. Castrillo; SAF2015- 64287-R, SAF2015-71878-REDT (MIN ECO), and CardioNext-ITN-608027 (European Commission FP7) to M. Ricote; and R01 AI089824 (National Institutes of Health) to C.V. Rothlin. H.P. is supported by grants from MIN ECO (SAF2014-54541-R), ATR ESMED IA – AXA, Asociación Española Contra el Cáncer, WHRI Academy, and Worldwide Cancer Research. The Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC) is supported by the MIN ECO and the Pro-CNIC Foundation, and is a Severo Ochoa Center of Excellence (MIN ECO award SEV-2015-0505). | |
dc.language.iso | eng | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | * |
dc.subject.mesh | Interleukin-1beta | es_ES |
dc.subject.mesh | Lectins, C-Type | es_ES |
dc.subject.mesh | Macrophages | es_ES |
dc.subject.mesh | Male | es_ES |
dc.subject.mesh | Mannose-Binding Lectins | es_ES |
dc.subject.mesh | Mice | es_ES |
dc.subject.mesh | Opsonin Proteins | es_ES |
dc.subject.mesh | Phagocytosis | es_ES |
dc.subject.mesh | Receptors, Cell Surface | es_ES |
dc.subject.mesh | Transcription Factors | es_ES |
dc.title | Phagocytosis imprints heterogeneity in tissue-resident macrophages | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Atribución-NoComercial-CompartirIgual 4.0 Internacional | * |
dc.identifier.pubmedID | 28432199 | es_ES |
dc.format.volume | 214 | es_ES |
dc.format.number | 5 | es_ES |
dc.format.page | 1281-1296 | es_ES |
dc.identifier.doi | 10.1084/jem.20161375 | es_ES |
dc.contributor.funder | Ministerio de Economía, Industria y Competitividad (España) | |
dc.contributor.funder | Unión Europea. Comisión Europea | |
dc.contributor.funder | National Institutes of Health (Estados Unidos) | |
dc.contributor.funder | Atresmedia | |
dc.contributor.funder | Asociación Española Contra el Cáncer | |
dc.contributor.funder | Worldwide Cancer Research | |
dc.contributor.funder | Fundación ProCNIC | |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 1540-9538 | es_ES |
dc.relation.publisherversion | J Exp Med. 2017; 214(5):1281-1296 | |
dc.identifier.journal | The Journal of experimental medicine | es_ES |
dc.repisalud.orgCNIC | CNIC::Grupos de investigación::Imagen de la Inflamación Cardiovascular y la Respuesta Inmune | es_ES |
dc.repisalud.orgCNIC | CNIC::Grupos de investigación::Señalización de los Receptores Nucleares | es_ES |
dc.repisalud.institucion | CNIC | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/FP7/608027/EU | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/SAF2015-65607 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/SEV-2015-0505 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/SAF2013-49662-EXP | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/SVP-2014-068595 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/BES-2013-065550 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/JCI-2012-12659 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/SAF2014-56819-R | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/SAF-2015-71878-REDT | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/SAF2015-64287-R | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/SAF2014-54541-R | es_ES |
dc.rights.accessRights | open access | es_ES |