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dc.contributor.authorAlmoguera, Berta
dc.contributor.authorRiveiro-Alvarez, Rosa
dc.contributor.authorLopez-Castroman, Jorge
dc.contributor.authorDorado, Pedro
dc.contributor.authorLopez-Rodriguez, Rosario
dc.contributor.authorFernandez-Navarro, Pablo L 
dc.contributor.authorBaca-García, Enrique
dc.contributor.authorFernandez-Piqueras, Jose
dc.contributor.authorDal-Ré, Rafael
dc.contributor.authorAbad-Santos, Francisco
dc.contributor.authorLlerena, Adrián
dc.contributor.authorAyuso, Carmen
dc.date.accessioned2018-12-13T11:22:55Z
dc.date.available2018-12-13T11:22:55Z
dc.date.issued2011-06-09
dc.identifier.citationBMC Med Genet. 2011; 12: 81.es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/6843
dc.description.abstractBACKGROUND: Three IL-10 gene promoter single nucleotide polymorphisms -1082G > A, -819C > T and -592C > A and the haplotypes they define in Caucasians, GCC, ACC, ATA, associated with different IL-10 production rates, have been linked to schizophrenia in some populations with conflicting results. On the basis of the evidence of the sex-dependent effect of certain genes in many complex diseases, we conducted a sex-stratified case-control association study to verify the linkage of the IL-10 gene promoter SNPs and haplotypes with schizophrenia and the possible sex-specific genetic effect in a Spanish schizophrenic population. METHODS: 241 DSM-IV diagnosed Spanish schizophrenic patients and 435 ethnically matched controls were genotyped for -1082G > A and -592C > A SNPs. Chi squared tests were performed to assess for genetic association of alleles, genotypes and haplotypes with the disease. RESULTS: The -1082A allele (p = 0.027), A/A (p = 0.008) and ATA/ATA (p = 0.003) genotypes were significantly associated with schizophrenia in females while neither allelic nor genotypic frequencies reached statistical significance in the male population. CONCLUSIONS: Our results highlight the hypothesis of an imbalance towards an inflammatory syndrome as the immune abnormality of schizophrenia. Anyway, a better understanding of the involvement of the immune system would imply the search of immune abnormalities in endophenotypes in whose sex and ethnicity might be differential factors. It also reinforces the need of performing complex gene studies based on multiple cytokine SNPs, including anti and pro-inflammatory, to clarify the immune system abnormalities direction in the etiology of schizophrenia.es_ES
dc.description.sponsorshipThis study has been supported by grants EC07/90393, EC07/90466 and EC07/90604, from Fondo de Investigacion Sanitaria (FIS). Berta Almoguera's work is supported by a Rio Hortega grant from Instituto de Salud Carlos III. Pedro Dorado is supported by the Instituto de Salud Carlos III-FIS and European Union (FEDER) grant CP06/00030.es_ES
dc.language.isoenges_ES
dc.publisherBioMed Central (BMC) es_ES
dc.type.hasVersionVoRes_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subject.meshAdult es_ES
dc.subject.meshAlleles es_ES
dc.subject.meshCase-Control Studies es_ES
dc.subject.meshDiagnostic and Statistical Manual of Mental Disorders es_ES
dc.subject.meshEuropean Continental Ancestry Group es_ES
dc.subject.meshFemale es_ES
dc.subject.meshGenetic Predisposition to Disease es_ES
dc.subject.meshGenotype es_ES
dc.subject.meshHaplotypes es_ES
dc.subject.meshHomozygote es_ES
dc.subject.meshHumans es_ES
dc.subject.meshInterleukin-10 es_ES
dc.subject.meshMale es_ES
dc.subject.meshMiddle Aged es_ES
dc.subject.meshPolymorphism, Single Nucleotidees_ES
dc.subject.meshPromoter Regions, Genetic es_ES
dc.subject.meshRisk Factors es_ES
dc.subject.meshSchizophrenia es_ES
dc.subject.meshSex Factors es_ES
dc.subject.meshSpain es_ES
dc.titleATA homozigosity in the IL-10 gene promoter is a risk factor for schizophrenia in Spanish females: a case control studyes_ES
dc.typejournal articlees_ES
dc.rights.licenseAtribución-4.0 Internacional*
dc.identifier.pubmedID21658228es_ES
dc.format.volume12es_ES
dc.format.page81es_ES
dc.identifier.doi10.1186/1471-2350-12-81es_ES
dc.contributor.funderInstituto de Salud Carlos III 
dc.description.peerreviewedes_ES
dc.identifier.e-issn1471-2350es_ES
dc.relation.publisherversionhttps://doi.org/10.1186/1471-2350-12-81es_ES
dc.identifier.journalBMC medical geneticses_ES
dc.repisalud.centroISCIII::Centro Nacional de Epidemiologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.rights.accessRightsopen accesses_ES


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