Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/6816
Título
Frequency of breast cancer with hereditary risk features in Spain: Analysis from GEICAM "El Álamo III" retrospective study
Autor(es)
Márquez-Rodas, Iván | Pollan-Santamaria, Marina ISCIII | Escudero, María José | Ruiz, Amparo | Martín, Miguel | Santaballa, Ana | Martínez Del Prado, Purificación | Batista, Norberto | Andrés, Raquel | Antón, Antonio | Llombart, Antonio | Fernandez Aramburu, Antonio | Adrover, Encarna | González, Sonia | Seguí, Miguel Angel | Calvo, Lourdes | Lizón, José | Rodríguez Lescure, Álvaro | Ramón Y Cajal, Teresa | Llort, Gemma | Jara, Carlos | Carrasco, Eva | López-Tarruella, Sara
Fecha de publicación
2017-10-05
Cita
PLoS One. 2017 Oct 6;12(10):e0184181.
Idioma
Inglés
Tipo de documento
journal article
Resumen
PURPOSE: To determine the frequency of breast cancer (BC) patients with hereditary risk features in a wide retrospective cohort of patients in Spain. METHODS: a retrospective analysis was conducted from 10,638 BC patients diagnosed between 1998 and 2001 in the GEICAM registry "El Álamo III", dividing them into four groups according to modified ESMO and SEOM hereditary cancer risk criteria: Sporadic breast cancer group (R0); Individual risk group (IR); Familial risk group (FR); Individual and familial risk group (IFR) with both individual and familial risk criteria. RESULTS: 7,641 patients were evaluable. Of them, 2,252 patients (29.5%) had at least one hereditary risk criteria, being subclassified in: FR 1.105 (14.5%), IR 970 (12.7%), IFR 177 (2.3%). There was a higher frequency of newly diagnosed metastatic patients in the IR group (5.1% vs 3.2%, p = 0.02). In contrast, in RO were lower proportion of big tumors (> T2) (43.8% vs 47.4%, p = 0.023), nodal involvement (43.4% vs 48.1%, p = 0.004) and lower histological grades (20.9% G3 for the R0 vs 29.8%) when compared to patients with any risk criteria. CONCLUSIONS: Almost three out of ten BC patients have at least one hereditary risk cancer feature that would warrant further genetic counseling. Patients with hereditary cancer risk seems to be diagnosed with worse prognosis factors.
MESH
Adult | Breast Neoplasms | Female | Genetic Counselins | Humans | Middle Aged | Prevalence | Prognosis | Registries | Retrospective Studies | Spain | Genetic Predisposition to Disease
Versión en línea
DOI
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