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dc.contributor.authorOchando, Jordi 
dc.contributor.authorBerzosa, Pedro 
dc.contributor.authorLucio, Aida de 
dc.contributor.authorDescalzo, Miguel Angel 
dc.contributor.authorBobuakasi, Leonardo
dc.contributor.authorNzambo, Sisinio
dc.contributor.authorOndo, Melchor
dc.contributor.authorBuatiche, Jesus N
dc.contributor.authorNseng, Gloria
dc.contributor.authorBenito, Agustin
dc.identifier.citationMalar J. 2007; 6: 141.es_ES
dc.description.abstractBACKGROUND: Malaria transmission in Equatorial Guinea and its space-time variability has been widely studied, but there is not much information about the transmission of malaria on the small island of Annobon. In 2004, two transversal studies were carried out to establish the malaria transmission pattern on Annobon and analyse the circulating Plasmodium falciparum allelic forms. METHODS: A blood sample was taken from the selected children in order to determine Plasmodium infection by microscopical examination and by semi-nested multiplex PCR. The diversity of P. falciparum circulating alleles was studied on the basis of the genes encoding for the merozoite surface proteins, MSP-1 and MSP-2 of P. falciparum. RESULTS: The crude parasite rate was 17% during the dry season and 60% during the rainy season. The percentage of children sleeping under a bed net was over 80% in the two surveys. During the rainy season, 33.3% of the children surveyed were anaemic at the time of the study. No association was found between the crude parasite rate, the use of bed nets and gender, and anaemia. However, children between five and nine years of age were five times less at risk of being anaemic than those aged less than one year. A total of 28 populations of the three allelic families of the msp-1 gene were identified and 39 of the msp-2 gene. The variability of circulating allelic populations is significantly higher in the rainy than in the dry season, although the multiplicity of infections is similar in both, 2.2 and 1.9 respectively. CONCLUSION: Based on the high degree of geographical isolation of the Annobon population and the apparent marked seasonality of the transmission, it is feasible to believe that malaria can be well controlled from this small African island.es_ES
dc.description.sponsorshipWe would like to thank the National Malaria Control Programme, the Republic of Equatorial Guinea's Ministry of Health and Social Welfare, for its technical support in order to have been able to conduct the study. This study was funded by the Spanish International Cooperation Agency (AECI) and the Instituto de Salud Carlos III within the Network of Tropical Diseases Research Centers (RICET-RD06/0021)es_ES
dc.publisherBioMed Central (BMC) es_ES
dc.subject.meshAge Distribution es_ES
dc.subject.meshAnimals es_ES
dc.subject.meshBedding and Linens es_ES
dc.subject.meshChild es_ES
dc.subject.meshChild, Preschool es_ES
dc.subject.meshEquatorial Guinea es_ES
dc.subject.meshFemale es_ES
dc.subject.meshGenotype es_ES
dc.subject.meshGeography es_ES
dc.subject.meshHumans es_ES
dc.subject.meshInsecticides es_ES
dc.subject.meshMalaria, Falciparum es_ES
dc.subject.meshMale es_ES
dc.subject.meshPlasmodium falciparum es_ES
dc.subject.meshSeasons es_ES
dc.subject.meshSex Characteristics es_ES
dc.subject.meshTime Factors es_ES
dc.subject.meshGenetic Variation es_ES
dc.titleTransmission of malaria and genotypic variability of Plasmodium falciparum on the island of Annobon (Equatorial Guinea)es_ES
dc.typejournal articlees_ES
dc.rights.licenseAtribución 2.0 Internacional*
dc.contributor.funderRETICS-Investigación colaborativa en Enfermedades Tropicales (RICET-ISCIII) (España) 
dc.identifier.journalMalaria journales_ES
dc.repisalud.centroISCIII::Centro Nacional de Medicina Tropicales_ES
dc.repisalud.centroISCIII::Escuela Nacional de Sanidades_ES
dc.rights.accessRightsopen accesses_ES

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Atribución 2.0 Internacional
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