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dc.contributor.authorSaiz, Maria Laura 
dc.contributor.authorRocha-Perugini, Vera 
dc.contributor.authorSanchez-Madrid, Francisco 
dc.date.accessioned2018-11-22T08:10:50Z
dc.date.available2018-11-22T08:10:50Z
dc.date.issued2018
dc.identifierISI:000432822900001
dc.identifier.citationFront Immunol. 2018; 9:1074
dc.identifier.issn1664-3224
dc.identifier.urihttp://hdl.handle.net/20.500.12105/6667
dc.description.abstractProfessional antigen-presenting cells (APCs) include dendritic cells, monocytes, and B cells. APCs internalize and process antigens, producing immunogenic peptides that enable antigen presentation to T lymphocytes, which provide the signals that trigger T-cell activation, proliferation, and differentiation, and lead to adaptive immune responses. After detection of microbial antigens through pattern recognition receptors (PRRs), APCs migrate to secondary lymphoid organs where antigen presentation to T lymphocytes takes place. Tetraspanins are membrane proteins that organize specialized membrane platforms, called tetraspanin-enriched microdomains, which integrate membrane receptors, like PRR and major histocompatibility complex class II (MHC-II), adhesion proteins, and signaling molecules. Importantly, through the modulation of the function of their associated membrane partners, tetraspanins regulate different steps of the immune response. Several tetraspanins can positively or negatively regulate the activation threshold of immune receptors. They also play a role during migration of APCs by controlling the surface levels and spatial arrangement of adhesion molecules and their subsequent intracellular signaling. Finally, tetraspanins participate in antigen processing and are important for priming of naive T cells through the control of T-cell co-stimulation and MHC-II-dependent antigen presentation. In this review, we discuss the role of tetraspanins in APC biology and their involvement in effective immune responses.
dc.description.sponsorshipThis work was supported by grants to FS-M (SAF2014-54705-R; SAF2017-82886-R; B2017/BMD-3671-INFLAMUNE; ERC-2011-AdG 294340-GENTRIS; PIE13/00041; and CIBER CARDIOVASCULAR) and was co-funded by Fondo Europeo de Desarrollo Regional (FEDER). The CNIC is supported by the Spanish Ministry of Economy, Industry and Competitiveness (MINECO) and by the Pro CNIC Foundation.
dc.language.isoeng
dc.publisherFrontiers Media 
dc.type.hasVersionVoR
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectTetraspanins
dc.subjectTetraspanin-enriched microdomains
dc.subjectAntigen-presenting cells
dc.subjectImmune receptors
dc.subjectCell migration
dc.subjectAntigen presentation
dc.subjectMHC CLASS-II
dc.subjectPLASMACYTOID DENDRITIC CELLS
dc.subjectHEPATITIS-C VIRUS
dc.subjectT-CELLS
dc.subjectMOLECULAR CHARACTERIZATION
dc.subjectMEMBRANE MICRODOMAIN
dc.subjectSIGNALING COMPLEXES
dc.subjectPEPTIDE COMPLEXES
dc.subjectDISTINCT SUBSET
dc.subjectDOWN-REGULATION
dc.titleTetraspanins as Organizers of Antigen-Presenting Cell Function
dc.typejournal article
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID29875769
dc.format.volume9
dc.identifier.doi10.3389/fimmu.2018.01074
dc.contributor.funderEuropean Regional Development Fund 
dc.contributor.funderMinisterio de Economía, Innovación y Competitividad (España) 
dc.contributor.funderFundación ProCNIC 
dc.contributor.funderCentro de Investigación Biomedica en Red - CIBER
dc.contributor.funderUnión Europea. Comisión Europea 
dc.contributor.funderUnión Europea. Comisión Europea. European Research Council (ERC) 
dc.description.peerreviewed
dc.relation.publisherversionhttps://doi.org/10.3389/fimmu.2018.01074
dc.identifier.journalFrontiers in Immunology
dc.repisalud.orgCNICCNIC::Grupos de investigación::Comunicación Intercelular en la Respuesta Inflamatoria
dc.repisalud.institucionCNIC
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/294340/EUes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SAF2014-54705-Res_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SAF2017-82886-Res_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/B2017/BMD-3671-INFLAMUNEes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PIE13/00041es_ES
dc.rights.accessRightsopen accesses_ES


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