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dc.contributor.author | Villa del Campo, Cristina | |
dc.contributor.author | Claveria, Cristina | |
dc.contributor.author | Sierra, Rocio | |
dc.contributor.author | Torres, Miguel | |
dc.date.accessioned | 2017-12-01T07:37:29Z | |
dc.date.available | 2017-12-01T07:37:29Z | |
dc.date.issued | 2014 | |
dc.identifier | ISI:000343867400016 | |
dc.identifier.citation | Cell Rep. 2014; 8(6):1741-51 | |
dc.identifier.issn | 2211-1247 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/5540 | |
dc.description.abstract | Heterogeneous anabolic capacity in cell populations can trigger a phenomenon known as cell competition, through which less active cells are eliminated. Cell competition has been induced experimentally in stem/precursor cell populations in insects and mammals and takes place endogenously in early mouse embryonic cells. Here, we show that cell competition can be efficiently induced in mouse cardiomyocytes by mosaic overexpression of Myc during both gestation and adult life. The expansion of the Myc-overexpressing cardiomyocyte population is driven by the elimination of wild-type cardiomyocytes. Importantly, this cardiomyocyte replacement is phenotypically silent and does not affect heart anatomy or function. These results show that the capacity for cell competition in mammals is not restricted to stem cell populations and suggest that stimulated cell competition has potential as a cardio-myocyte-replacement strategy. | |
dc.description.sponsorship | We thank J.L. de la Pompa for comments on the manuscript, V. Garcia for mouse work, E. Arza and A. M. Santos for help with microscopy and 3D reconstruction, J. Garcia-Prieto for help with cardiomyocyte isolation, A. V. Alonso for the echocardiography assays, F. Sanchez-Cabo for statistics, and S. Bartlett for text editing. The CNIC Genomics unit performed the RNA sequencing procedures. This work was supported by grants BFU2012-31086 and RD12/0019/0005 (ISCIII) from the Spanish Ministry of Economy and Competition (MINECO) and grant P2010/BMD-2315 from the Madrid Regional Government. C. V. is supported by a FPI grant from the MINECO. The CNIC is supported by the MINECO and the Pro-CNIC Foundation. | |
dc.language.iso | eng | |
dc.publisher | Cell Press | |
dc.type.hasVersion | VoR | |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | CARDIAC PROGENITOR CELLS | |
dc.subject | C-MYC | |
dc.subject | MYOCYTE HYPERTROPHY | |
dc.subject | CIRCADIAN CLOCK | |
dc.subject | DNA-SYNTHESIS | |
dc.subject | IN-VIVO | |
dc.subject | DROSOPHILA | |
dc.subject | RECEPTOR | |
dc.subject | PATHWAY | |
dc.subject | DEATH | |
dc.title | Cell Competition Promotes Phenotypically Silent Cardiomyocyte Replacement in the Mammalian Heart | |
dc.type | journal article | |
dc.rights.license | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.identifier.pubmedID | 25199831 | |
dc.format.volume | 8 | |
dc.format.page | 1741-1751 | |
dc.identifier.doi | 10.1016/j.celrep.2014.08.005 | |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | |
dc.contributor.funder | Comunidad de Madrid (España) | |
dc.contributor.funder | Fundación ProCNIC | |
dc.description.peerreviewed | Sí | |
dc.relation.publisherversion | https://doi.org/10.1016/j.celrep.2014.08.005 | |
dc.identifier.journal | Cell Reports | |
dc.repisalud.orgCNIC | CNIC::Grupos de investigación::Control Genético del Desarrollo y Regeneración de Órganos | |
dc.repisalud.institucion | CNIC | |
dc.rights.accessRights | open access | es_ES |