Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/5540
Título
Cell Competition Promotes Phenotypically Silent Cardiomyocyte Replacement in the Mammalian Heart
Autor(es)
Fecha de publicación
2014
Cita
Cell Rep. 2014; 8(6):1741-51
Idioma
Inglés
Tipo de documento
journal article
Resumen
Heterogeneous anabolic capacity in cell populations can trigger a phenomenon known as cell competition, through which less active cells are eliminated. Cell competition has been induced experimentally in stem/precursor cell populations in insects and mammals and takes place endogenously in early mouse embryonic cells. Here, we show that cell competition can be efficiently induced in mouse cardiomyocytes by mosaic overexpression of Myc during both gestation and adult life. The expansion of the Myc-overexpressing cardiomyocyte population is driven by the elimination of wild-type cardiomyocytes. Importantly, this cardiomyocyte replacement is phenotypically silent and does not affect heart anatomy or function. These results show that the capacity for cell competition in mammals is not restricted to stem cell populations and suggest that stimulated cell competition has potential as a cardio-myocyte-replacement strategy.
Palabras clave
CARDIAC PROGENITOR CELLS | C-MYC | MYOCYTE HYPERTROPHY | CIRCADIAN CLOCK | DNA-SYNTHESIS | IN-VIVO | DROSOPHILA | RECEPTOR | PATHWAY | DEATH
Versión en línea
DOI
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