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dc.contributor.authorGiudice, Girolamo 
dc.contributor.authorSanchez-Cabo, Fatima 
dc.contributor.authorTorroja, Carlos 
dc.contributor.authorLara-Pezzi, Enrique 
dc.date.accessioned2017-10-30T13:32:25Z
dc.date.available2017-10-30T13:32:25Z
dc.date.issued2016
dc.identifierISI:000374095000001
dc.identifier.citationDatabase (Oxford). 2016; 2016:baw035
dc.identifier.issn1758-0463
dc.identifier.urihttp://hdl.handle.net/20.500.12105/5239
dc.description.abstractRNA-binding proteins (RBPs) play a crucial role in key cellular processes, including RNA transport, splicing, polyadenylation and stability. Understanding the interaction between RBPs and RNA is key to improve our knowledge of RNA processing, localization and regulation in a global manner. Despite advances in recent years, a unified non-redundant resource that includes information on experimentally validated motifs, RBPs and integrated tools to exploit this information is lacking. Here, we developed a database named ATtRACT (available at http://attract.cnic.es) that compiles information on 370 RBPs and 1583 RBP consensus binding motifs, 192 of which are not present in any other database. To populate ATtRACT we (i) extracted and hand-curated experimentally validated data from CISBP-RNA, SpliceAid-F, RBPDB databases, (ii) integrated and updated the unavailable ASD database and (iii) extracted information from Protein-RNA complexes present in Protein Data Bank database through computational analyses. ATtRACT provides also efficient algorithms to search a specific motif and scan one or more RNA sequences at a time. It also allows discovering de novo motifs enriched in a set of related sequences and compare them with the motifs included in the database.
dc.description.sponsorshipThis work was supported by grants from the European Union's Seventh Framework Programme (CardioNext ITN-608027, CardioNeT ITN-289600), from the Spanish Ministry of Science and Innovation (SAF2012-31451) and from the Regional Government of Madrid (2010-BMD-2321 `Fibroteam') to E.L.-P.). Funding for open access charge: EU FP7, grant CardioNext ITN-608027.
dc.language.isoeng
dc.publisherOXFORD UNIV PRESS
dc.relation.isversionofPublisher's version
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectGENE-REGULATION
dc.subjectNUCLEIC-ACID
dc.subjectWEB SERVER
dc.subjectDISCOVERY
dc.subjectSEQUENCES
dc.subjectPROGRAM
dc.titleATtRACT-a database of RNA-binding proteins and associated motifs
dc.typeArtículo
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID27055826
dc.identifier.doi10.1093/database/baw035
dc.contributor.funderEC-European Commission
dc.contributor.funderMinisterio de Economía y Competitividad (España)
dc.contributor.funderComunidad de Madrid
dc.description.peerreviewed
dc.relation.publisherversionhttps://doi.org/10.1093/database/baw035
dc.identifier.journalDatabase-The Journal of Biological Database and Curation
dc.repisalud.orgCNICCNIC::Grupos de investigación::Regulación Molecular de la Insuficiencia Cardiaca
dc.repisalud.orgCNICCNIC::Unidades técnicas::Bioinformática
dc.repisalud.institucionCNIC
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/289600es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/608027es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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