Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/5239
Título
ATtRACT-a database of RNA-binding proteins and associated motifs
Autor(es)
Giudice, Girolamo CNIC | Sanchez-Cabo, Fatima CNIC | Torroja, Carlos CNIC | Lara-Pezzi, Enrique CNIC
Fecha de publicación
2016
Cita
Database (Oxford). 2016; 2016:baw035
Idioma
Inglés
Tipo de documento
journal article
Resumen
RNA-binding proteins (RBPs) play a crucial role in key cellular processes, including RNA transport, splicing, polyadenylation and stability. Understanding the interaction between RBPs and RNA is key to improve our knowledge of RNA processing, localization and regulation in a global manner. Despite advances in recent years, a unified non-redundant resource that includes information on experimentally validated motifs, RBPs and integrated tools to exploit this information is lacking. Here, we developed a database named ATtRACT (available at http://attract.cnic.es) that compiles information on 370 RBPs and 1583 RBP consensus binding motifs, 192 of which are not present in any other database. To populate ATtRACT we (i) extracted and hand-curated experimentally validated data from CISBP-RNA, SpliceAid-F, RBPDB databases, (ii) integrated and updated the unavailable ASD database and (iii) extracted information from Protein-RNA complexes present in Protein Data Bank database through computational analyses. ATtRACT provides also efficient algorithms to search a specific motif and scan one or more RNA sequences at a time. It also allows discovering de novo motifs enriched in a set of related sequences and compare them with the motifs included in the database.
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