Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/5222
Título
Interplay between hepatic mitochondria-associated membranes, lipid metabolism and caveolin-1 in mice
Autor(es)
Sala-Vila, Aleix CNIC | Navarro-Lerida, Inmaculada CNIC | Sanchez-Alvarez, Miguel CNIC | Bosch, Marta | Calvo, Carlos | Lopez, Juan Antonio CNIC | Calvo, Enrique CNIC | Ferguson, Charles | Giacomello, Marta | Serafini, Annalisa | Scorrano, Luca | Enriquez, Jose Antonio CNIC | Balsinde, Jesus | Parton, Robert G. | Vazquez, Jesus CNIC | Pol, Albert | del Pozo, Miguel Angel CNIC
Fecha de publicación
2016
Cita
Sci Rep. 2016; 6:27351
Idioma
Inglés
Tipo de documento
journal article
Resumen
The mitochondria-associated membrane (MAM) is a specialized subdomain of the endoplasmic reticulum (ER) which acts as an intracellular signaling hub. MAM dysfunction has been related to liver disease. We report a high-throughput mass spectrometry-based proteomics characterization of MAMs from mouse liver, which portrays them as an extremely complex compartment involved in different metabolic processes, including steroid metabolism. Interestingly, we identified caveolin-1 (CAV1) as an integral component of hepatic MAMs, which determine the relative cholesterol content of these ER subdomains. Finally, a detailed comparative proteomics analysis between MAMs from wild type and CAV1-deficient mice suggests that functional CAV1 contributes to the recruitment and regulation of intracellular steroid and lipoprotein metabolism-related processes accrued at MAMs. The potential impact of these novel aspects of CAV1 biology on global cell homeostasis and disease is discussed.
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