Mostrar el registro sencillo del ítem
dc.contributor.author | Del Toro, Raquel | |
dc.contributor.author | Chevre, Raphael | |
dc.contributor.author | Rodriguez, Cristina | |
dc.contributor.author | Ordonez, Antonio | |
dc.contributor.author | Martinez-Gonzalez, Jose | |
dc.contributor.author | Andres, Vicente | |
dc.contributor.author | Mendez-Ferrer, Simon | |
dc.date.accessioned | 2017-10-20T10:33:52Z | |
dc.date.available | 2017-10-20T10:33:52Z | |
dc.date.issued | 2016 | |
dc.identifier | ISI:000384973300001 | |
dc.identifier.citation | Nat Commun. 2016; 7:12706 | |
dc.identifier.issn | 2041-1723 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/5185 | |
dc.description.abstract | Atherosclerosis is a leading death cause. Endothelial and smooth muscle cells participate in atherogenesis, but it is unclear whether other mesenchymal cells contribute to this process. Bone marrow (BM) nestin(+) cells cooperate with endothelial cells in directing monocyte egress to bloodstream in response to infections. However, it remains unknown whether nestin(+) cells regulate inflammatory cells in chronic inflammatory diseases, such as atherosclerosis. Here, we show that nestin(+) cells direct inflammatory cell migration during chronic inflammation. In Apolipoprotein E (ApoE) knockout mice fed with high-fat diet, BM nestin(+) cells regulate the egress of inflammatory monocytes and neutrophils. In the aorta, nestin(+) stromal cells increase similar to 30 times and contribute to the atheroma plaque. Mcp1 deletion in nestin(+) cells-but not in endothelial cells only-increases circulating inflammatory cells, but decreases their aortic infiltration, delaying atheroma plaque formation and aortic valve calcification. Therefore, nestin expression marks cells that regulate inflammatory cell migration during atherosclerosis. | |
dc.description.sponsorship | We thank EG Pamer, GN Enikolopov, G Fishell and RH Adams for donating mice. X Langa, S Martin-Salamanca, D Martin-Perez, R Villa-Bellosta, I Bilbao, J Ruiz-Cabello, AM Martin, AB Ricote, JM Ligos, R Nieto, A Benitez and the CNIC Comparative Medicine, Cellomics and Microscopy Units for assistance, and other members of S.M-F. lab for helpful discussions. This work was supported by core support grants from the Pro-CNIC Foundation, Severo Ochoa Center of Excellence award SEV-2015-0505 to CNIC, and the Wellcome Trust and MRC to the Cambridge Stem Cell Institute, Spanish Ministry of Economy and Competitiveness (RETIC Grant RD12/0042/0028 to V.A.; SAF2012-40127 to J.M-G.; Plan Nacional Grant SAF-2011-30308, Ramon y Cajal Program Grant RYC-2009-04703 and Spanish Cell Therapy Network TerCel to S.M-F.); Marie Curie Career Integration Program Grant (FP7-PEOPLE-2011-294096) and ConSEPOC-Comunidad de Madrid Grant (S2010/BMD-2542), National Health Institute Blood and Transplant (United Kingdom), Horizon2020 (ERC-2014-CoG-64765) and an International Early Career Scientist grant of the Howard Hughes Medical Institute to S.M-F. | |
dc.language.iso | eng | |
dc.publisher | Nature Publishing Group | |
dc.type.hasVersion | VoR | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | MYELOID CALCIFYING CELLS | |
dc.subject | SMOOTH-MUSCLE-CELLS | |
dc.subject | PROGENITOR CELLS | |
dc.subject | VASA-VASORUM | |
dc.subject | STEM-CELLS | |
dc.subject | HEMATOPOIETIC STEM | |
dc.subject | MONOCYTE RECRUITMENT | |
dc.subject | NEOINTIMA FORMATION | |
dc.subject | ENDOTHELIAL-CELLS | |
dc.subject | MESENCHYMAL STEM | |
dc.title | Nestin(+) cells direct inflammatory cell migration in atherosclerosis | |
dc.type | journal article | |
dc.rights.license | Atribución 4.0 Internacional | * |
dc.identifier.pubmedID | 27586429 | |
dc.format.volume | 7 | |
dc.identifier.doi | 10.1038/ncomms12706 | |
dc.contributor.funder | Fundación ProCNIC | |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | |
dc.contributor.funder | Wellcome Trust | |
dc.contributor.funder | MRC Cambridge Stem Cell Institute | |
dc.contributor.funder | Comunidad de Madrid (España) | |
dc.contributor.funder | Unión Europea. Comisión Europea | |
dc.contributor.funder | Howard Hughes Medical Institute | |
dc.contributor.funder | NHS - Blood and Transplant (NHSBT) (Reino Unido) | |
dc.description.peerreviewed | Sí | |
dc.relation.publisherversion | https://doi.org/10.1038/ncomms12706 | |
dc.identifier.journal | Nature Communications | |
dc.repisalud.orgCNIC | CNIC::Grupos de investigación::Fisiopatología Cardiovascular Molecular y Genética | |
dc.repisalud.orgCNIC | CNIC::Grupos de investigación::Antiguos CNIC | |
dc.repisalud.institucion | CNIC | |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/FP7/294096/EU | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/SEV-2015-0505 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/64765 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/SAF2012-40127 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/SAF-2011-30308 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/RYC-2009-04703 | es_ES |
dc.rights.accessRights | open access | es_ES |