Please use this identifier to cite or link to this item:http://hdl.handle.net/20.500.12105/5185
Nestin(+) cells direct inflammatory cell migration in atherosclerosis
Nat Commun. 2016; 7:12706
Atherosclerosis is a leading death cause. Endothelial and smooth muscle cells participate in atherogenesis, but it is unclear whether other mesenchymal cells contribute to this process. Bone marrow (BM) nestin(+) cells cooperate with endothelial cells in directing monocyte egress to bloodstream in response to infections. However, it remains unknown whether nestin(+) cells regulate inflammatory cells in chronic inflammatory diseases, such as atherosclerosis. Here, we show that nestin(+) cells direct inflammatory cell migration during chronic inflammation. In Apolipoprotein E (ApoE) knockout mice fed with high-fat diet, BM nestin(+) cells regulate the egress of inflammatory monocytes and neutrophils. In the aorta, nestin(+) stromal cells increase similar to 30 times and contribute to the atheroma plaque. Mcp1 deletion in nestin(+) cells-but not in endothelial cells only-increases circulating inflammatory cells, but decreases their aortic infiltration, delaying atheroma plaque formation and aortic valve calcification. Therefore, nestin expression marks cells that regulate inflammatory cell migration during atherosclerosis.
MYELOID CALCIFYING CELLS | SMOOTH-MUSCLE-CELLS | PROGENITOR CELLS | VASA-VASORUM | STEM-CELLS | HEMATOPOIETIC STEM | MONOCYTE RECRUITMENT | NEOINTIMA FORMATION | ENDOTHELIAL-CELLS | MESENCHYMAL STEM
Files in this item