Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/5185
Título
Nestin(+) cells direct inflammatory cell migration in atherosclerosis
Autor(es)
Del Toro, Raquel CNIC | Chevre, Raphael CNIC | Rodriguez, Cristina | Ordonez, Antonio | Martinez-Gonzalez, Jose | Andres, Vicente CNIC | Mendez-Ferrer, Simon CNIC
Fecha de publicación
2016
Cita
Nat Commun. 2016; 7:12706
Idioma
Inglés
Tipo de documento
journal article
Resumen
Atherosclerosis is a leading death cause. Endothelial and smooth muscle cells participate in atherogenesis, but it is unclear whether other mesenchymal cells contribute to this process. Bone marrow (BM) nestin(+) cells cooperate with endothelial cells in directing monocyte egress to bloodstream in response to infections. However, it remains unknown whether nestin(+) cells regulate inflammatory cells in chronic inflammatory diseases, such as atherosclerosis. Here, we show that nestin(+) cells direct inflammatory cell migration during chronic inflammation. In Apolipoprotein E (ApoE) knockout mice fed with high-fat diet, BM nestin(+) cells regulate the egress of inflammatory monocytes and neutrophils. In the aorta, nestin(+) stromal cells increase similar to 30 times and contribute to the atheroma plaque. Mcp1 deletion in nestin(+) cells-but not in endothelial cells only-increases circulating inflammatory cells, but decreases their aortic infiltration, delaying atheroma plaque formation and aortic valve calcification. Therefore, nestin expression marks cells that regulate inflammatory cell migration during atherosclerosis.
Palabras clave
MYELOID CALCIFYING CELLS | SMOOTH-MUSCLE-CELLS | PROGENITOR CELLS | VASA-VASORUM | STEM-CELLS | HEMATOPOIETIC STEM | MONOCYTE RECRUITMENT | NEOINTIMA FORMATION | ENDOTHELIAL-CELLS | MESENCHYMAL STEM
Versión en línea
DOI
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