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dc.contributor.authorEnamorado, Michel 
dc.contributor.authorIborra, Salvador 
dc.contributor.authorPriego, Elena 
dc.contributor.authorCueto, Francisco J. 
dc.contributor.authorQuintana, Juan A. 
dc.contributor.authorMartinez-Cano, Sarai 
dc.contributor.authorMejias-Perez, Ernesto
dc.contributor.authorEsteban, Mariano
dc.contributor.authorMelero, Ignacio
dc.contributor.authorHidalgo, Andrés 
dc.contributor.authorSancho, David 
dc.date.accessioned2017-10-20T10:23:10Z
dc.date.available2017-10-20T10:23:10Z
dc.date.issued2017
dc.identifierISI:000405682100001
dc.identifier.citationNat Commun. 2017; 8:16073
dc.identifier.issn2041-1723
dc.identifier.urihttp://hdl.handle.net/20.500.12105/5105
dc.description.abstractThe goal of successful anti-tumoural immunity is the development of long-term protective immunity to prevent relapse. Infiltration of tumours with CD8(+) T cells with a resident memory (Trm) phenotype correlates with improved survival. However, the interplay of circulating CD8(+) T cells and Trm cells remains poorly explored in tumour immunity. Using different vaccination strategies that fine-tune the generation of Trm cells or circulating memory T cells, here we show that, while both subsets are sufficient for anti-tumour immunity, the presence of Trm cells improves anti-tumour efficacy. Transferred central memory T cells (Tcm) generate Trm cells following viral infection or tumour challenge. Anti-PD-1 treatment promotes infiltration of transferred Tcm cells within tumours, improving anti-tumour immunity. Moreover, Batf3-dependent dendritic cells are essential for reactivation of circulating memory anti-tumour response. Our findings show the plasticity, collaboration and requirements for reactivation of memory CD8(+) T cells subsets needed for optimal tumour vaccination and immunotherapy.
dc.description.sponsorshipWe are grateful to N. Anandasabapathy, J. Pardo and members of the D.S. lab for discussions and critical reading of the manuscript. We also thank R.A. Mota for the contribution to the development of animal models. We thank the CNIC facilities, personnel and to K. McCreath for editorial assistance. We are indebted to all the scientists who have shared reagents with us, as indicated in Methods. M.E. is the recipient of a CNIC International PhD Programme fellowship `La Caixa'-Severo Ochoa, 2013 Call (OSLC-CNIC-2013-04). S.I. is funded by grant SAF2015-74561-JIN. I. M. is supported by Asociacion Espanola contra el Cancer and Fundacion BBVA. A.H. is funded by the Spanish Ministry of Economy, Industry and Competitiveness (MEIC) and European Fund for Regional Development (FEDER) (SAF2015-65607-R). D.S. lab is funded by the MEIC and FEDER (SAF-2013-42920-R and SAF-2016-79040-R), and the Fondation ACTERIA. D.S. and I. M. lab are funded by the European Commission (635122-PRO-CROP H2020). D.S. and A.H. lab are funded by the CNIC. The CNIC is supported by the MEIC and the Pro CNIC Foundation, and is a Severo Ochoa Center of Excellence (SEV-2015-0505).
dc.language.isoeng
dc.publisherNATURE PUBLISHING GROUP
dc.relation.isversionofPublisher's version
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectTUMOR-INFILTRATING LYMPHOCYTES
dc.subjectCD8-ALPHA(+) DENDRITIC CELLS
dc.subjectTISSUE-RESIDENT
dc.subjectNONLYMPHOID TISSUE
dc.subjectVIRAL-INFECTION
dc.subjectRESPONSES
dc.subjectREVEALS
dc.subjectCANCER
dc.subjectIL-12
dc.subjectEXPRESSION
dc.titleEnhanced anti-tumour immunity requires the interplay between resident and circulating memory CD8(+) T cells
dc.typeArtículo
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID28714465
dc.format.volume8
dc.identifier.doi10.1038/ncomms16073
dc.contributor.funderAsociación Española Contra el Cáncer
dc.contributor.funderFundación BBVA
dc.contributor.funderMinisterio de Economía, Industria y Competitividad (España)
dc.contributor.funderUnión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
dc.contributor.funderFondation ACTERIA (Acting on European Research in Immunology and Allergology)
dc.contributor.funderUnión Europea. Comisión Europea
dc.contributor.funderCentro Nacional de Investigaciones Cardiovasculares (España)
dc.contributor.funderFundación ProCNIC
dc.description.peerreviewed
dc.relation.publisherversionhttps://doi.org/10.1038/ncomms16073
dc.identifier.journalNATURE COMMUNICATIONS
dc.repisalud.orgCNICCNIC::Grupos de investigación::Inmunobiología
dc.repisalud.orgCNICCNIC::Grupos de investigación::Imagen de la Inflamación Cardiovascular y la Respuesta Inmune
dc.repisalud.institucionCNIC
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SAF2015-65607-Res_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SAF-2013-42920-Res_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SAF-2016-79040-Res_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SEV-2015-0505es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/635122es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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