Please use this identifier to cite or link to this item:http://hdl.handle.net/20.500.12105/5105
Enhanced anti-tumour immunity requires the interplay between resident and circulating memory CD8(+) T cells
Nat Commun. 2017; 8:16073
The goal of successful anti-tumoural immunity is the development of long-term protective immunity to prevent relapse. Infiltration of tumours with CD8(+) T cells with a resident memory (Trm) phenotype correlates with improved survival. However, the interplay of circulating CD8(+) T cells and Trm cells remains poorly explored in tumour immunity. Using different vaccination strategies that fine-tune the generation of Trm cells or circulating memory T cells, here we show that, while both subsets are sufficient for anti-tumour immunity, the presence of Trm cells improves anti-tumour efficacy. Transferred central memory T cells (Tcm) generate Trm cells following viral infection or tumour challenge. Anti-PD-1 treatment promotes infiltration of transferred Tcm cells within tumours, improving anti-tumour immunity. Moreover, Batf3-dependent dendritic cells are essential for reactivation of circulating memory anti-tumour response. Our findings show the plasticity, collaboration and requirements for reactivation of memory CD8(+) T cells subsets needed for optimal tumour vaccination and immunotherapy.
TUMOR-INFILTRATING LYMPHOCYTES | CD8-ALPHA(+) DENDRITIC CELLS | TISSUE-RESIDENT | NONLYMPHOID TISSUE | VIRAL-INFECTION | RESPONSES | REVEALS | CANCER | IL-12 | EXPRESSION
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