dc.contributor.author | Enamorado, Michel | |
dc.contributor.author | Iborra, Salvador | |
dc.contributor.author | Priego, Elena | |
dc.contributor.author | Cueto, Francisco J. | |
dc.contributor.author | Quintana, Juan A. | |
dc.contributor.author | Martinez-Cano, Sarai | |
dc.contributor.author | Mejias-Perez, Ernesto | |
dc.contributor.author | Esteban, Mariano | |
dc.contributor.author | Melero, Ignacio | |
dc.contributor.author | Hidalgo, Andres | |
dc.contributor.author | Sancho, David | |
dc.date.accessioned | 2017-10-20T10:23:10Z | |
dc.date.available | 2017-10-20T10:23:10Z | |
dc.date.issued | 2017 | |
dc.identifier | ISI:000405682100001 | |
dc.identifier.citation | Nat Commun. 2017; 8:16073 | |
dc.identifier.issn | 2041-1723 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/5105 | |
dc.description.abstract | The goal of successful anti-tumoural immunity is the development of long-term protective immunity to prevent relapse. Infiltration of tumours with CD8(+) T cells with a resident memory (Trm) phenotype correlates with improved survival. However, the interplay of circulating CD8(+) T cells and Trm cells remains poorly explored in tumour immunity. Using different vaccination strategies that fine-tune the generation of Trm cells or circulating memory T cells, here we show that, while both subsets are sufficient for anti-tumour immunity, the presence of Trm cells improves anti-tumour efficacy. Transferred central memory T cells (Tcm) generate Trm cells following viral infection or tumour challenge. Anti-PD-1 treatment promotes infiltration of transferred Tcm cells within tumours, improving anti-tumour immunity. Moreover, Batf3-dependent dendritic cells are essential for reactivation of circulating memory anti-tumour response. Our findings show the plasticity, collaboration and requirements for reactivation of memory CD8(+) T cells subsets needed for optimal tumour vaccination and immunotherapy. | |
dc.description.sponsorship | We are grateful to N. Anandasabapathy, J. Pardo and members of the D.S. lab for discussions and critical reading of the manuscript. We also thank R.A. Mota for the contribution to the development of animal models. We thank the CNIC facilities, personnel and to K. McCreath for editorial assistance. We are indebted to all the scientists who have shared reagents with us, as indicated in Methods. M.E. is the recipient of a CNIC International PhD Programme fellowship `La Caixa'-Severo Ochoa, 2013 Call (OSLC-CNIC-2013-04). S.I. is funded by grant SAF2015-74561-JIN. I. M. is supported by Asociacion Espanola contra el Cancer and Fundacion BBVA. A.H. is funded by the Spanish Ministry of Economy, Industry and Competitiveness (MEIC) and European Fund for Regional Development (FEDER) (SAF2015-65607-R). D.S. lab is funded by the MEIC and FEDER (SAF-2013-42920-R and SAF-2016-79040-R), and the Fondation ACTERIA. D.S. and I. M. lab are funded by the European Commission (635122-PRO-CROP H2020). D.S. and A.H. lab are funded by the CNIC. The CNIC is supported by the MEIC and the Pro CNIC Foundation, and is a Severo Ochoa Center of Excellence (SEV-2015-0505). | |
dc.language.iso | eng | |
dc.publisher | Nature Publishing Group | |
dc.type.hasVersion | VoR | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | TUMOR-INFILTRATING LYMPHOCYTES | |
dc.subject | CD8-ALPHA(+) DENDRITIC CELLS | |
dc.subject | TISSUE-RESIDENT | |
dc.subject | NONLYMPHOID TISSUE | |
dc.subject | VIRAL-INFECTION | |
dc.subject | RESPONSES | |
dc.subject | REVEALS | |
dc.subject | CANCER | |
dc.subject | IL-12 | |
dc.subject | EXPRESSION | |
dc.title | Enhanced anti-tumour immunity requires the interplay between resident and circulating memory CD8(+) T cells | |
dc.type | journal article | |
dc.rights.license | Atribución 4.0 Internacional | * |
dc.identifier.pubmedID | 28714465 | |
dc.format.volume | 8 | |
dc.identifier.doi | 10.1038/ncomms16073 | |
dc.contributor.funder | Asociación Española Contra el Cáncer | |
dc.contributor.funder | Fundación BBVA | |
dc.contributor.funder | Ministerio de Economía, Industria y Competitividad (España) | |
dc.contributor.funder | Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) | |
dc.contributor.funder | Fondation ACTERIA (Acting on European Research in Immunology and Allergology) | |
dc.contributor.funder | Unión Europea. Comisión Europea | |
dc.contributor.funder | Centro Nacional de Investigaciones Cardiovasculares Carlos III (España) | |
dc.contributor.funder | Fundación ProCNIC | |
dc.description.peerreviewed | Sí | |
dc.relation.publisherversion | https://doi.org/10.1038/ncomms16073 | |
dc.identifier.journal | NATURE COMMUNICATIONS | |
dc.repisalud.orgCNIC | CNIC::Grupos de investigación::Inmunobiología | |
dc.repisalud.orgCNIC | CNIC::Grupos de investigación::Imagen de la Inflamación Cardiovascular y la Respuesta Inmune | |
dc.repisalud.institucion | CNIC | |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/SAF2015-65607-R | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/SAF-2013-42920-R | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/SAF-2016-79040-R | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/SEV-2015-0505 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/635122 | es_ES |
dc.rights.accessRights | open access | es_ES |