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dc.contributor.authorGuzmán-Fulgencio, María 
dc.contributor.authorBerenguer, Juan
dc.contributor.authorJimenez-Sousa, Maria Angeles 
dc.contributor.authorPineda-Tenor, Daniel 
dc.contributor.authorAldámiz-Echevarria, Teresa
dc.contributor.authorTrento, Alfonsina 
dc.contributor.authorCarrero, Ana
dc.contributor.authorGarcia-Alvarez, Monica 
dc.contributor.authorTejerina, Francisco
dc.contributor.authorDiez, Cristina
dc.contributor.authorVazquez-Moron, Sonia 
dc.contributor.authorResino, Salvador
dc.identifier.citationJ Transl Med. 2015;13:206
dc.description.abstractBackground Interleukin-7 (IL-7) is a critical factor for T cell development and for maintaining and restoring homeostasis of mature T cells. Polymorphisms at α-chain of the IL-7 receptor (IL7R or CD127) gene are related to evolution of HIV-infection, but there are no data concerning the evolution of hepatitis C virus (HCV) infection. The aim of this study was to analyze the association between IL7R polymorphisms and severe liver disease in HCV/HIV coinfected patients. Methods We performed a cross-sectional study in 220 naïve patients who underwent a liver biopsy. IL7R polymorphisms (rs6897932, rs987106 and rs3194051) were genotyped using the GoldenGate® assay. The outcome variables were: (a) liver biopsy: advanced fibrosis (F ≥ 3), severe activity grade (A3); (b) non-invasive indexes: advanced fibrosis (APRI ≥1.5 and FIB-4 ≥3.25). Logistic regression analysis was used to investigate the association between IL7R polymorphisms and outcome variables. This test gives the differences between groups and the odds ratio (OR) for liver disease. Results Patients with rs6897932 CC genotype had higher likelihood of having A3 than patients with rs6897932 CT/TT (adjusted odds ratio (aOR) = 4.16; p = 0.026). Patients with rs987106 TT genotype had higher odds of having F ≥ 3 (aOR = 3.09; p = 0.009) than rs987106 AA/AT carriers. Finally, patients with rs3194051 AA genotype had higher odds of having severe liver fibrosis (F ≥ 3; APRI ≥1.5, and FIB4 ≥3.25) than patients with rs3194051 AG/GG genotype [aOR = 2.73 (p = 0.010); aOR = 2.52 (p = 0.029); and aOR = 4.01 (p = 0.027); respectively]. The CTA haplotype (comprised of rs6897932, rs987106, and rs3194051) carriers had higher odds of having F ≥ 3 (aOR = 1.85; p = 0.012), APRI ≥1.5 (aOR = 1.94; p = 0.023), and FIB4 ≥3.25 (aOR = 2.47; p = 0.024). Conversely, the CAG haplotype carriers had lower odds of having F ≥ 3 (aOR = 0.48; p = 0.011), APRI ≥1.5 (aOR = 0.48; p = 0.029), and FIB4 ≥3.25 (aOR = 0.29; p = 0.010). Conclusions The presence of IL7R polymorphisms seems to be related to severe liver disease in HIV/HCV coinfected patients, because patients with unfavorable IL7R genotypes (rs6897932 CC, rs987106 TT, and rs3194051AA) had a worse prognosis of CHC.
dc.description.sponsorshipThis work has been supported by grants from Fondo de Investigación de Sanidad (FIS) [PI11/01556, PI14/01094, PI11/00245, PI14CIII/00011], and Fundación para la Investigación y la Prevención del Sida en España (FIPSE) [361020/10]. Besides, this work has been (partially) funded by the RD12/0017/0024 and RD12/0017/0004 projects as part of the Plan Nacional R + D + I and cofinanced by ISCIII- Subdirección General de Evaluación y el Fondo Europeo de Desarrollo Regional (FEDER). JB is an investigator from the Programa de Intensificación de la Actividad Investigadora en el Sistema Nacional de Salud (I3SNS) [INT10/009 and INT12/154]. DPT, MGF, MAJS, MGA, and PGB are supported by Instituto de Salud Carlos III [grant numbers CM12/00043, RD12/0017/0024, CD13/00013, CD12/00442, and FI12/00036, respectively]. “Este trabajo ha sido financiado por el proyecto RD12/0017, integrado en el Plan Nacional de I + D + I y cofinanciado por el ISCIII-Subdirección General de Evaluación y el Fondo Europeo de Desarrollo Regional (FEDER)”.
dc.publisherBioMed Central
dc.relation.isversionofPublisher's version
dc.subjectHepatic fibrosis
dc.subjectChronic hepatitis C
dc.titleAssociation between IL7R polymorphisms and severe liver disease in HIV/HCV coinfected patients: a cross-sectional study
dc.rights.licenseAtribución 4.0 Internacional*
dc.contributor.funderFondo de Investigaciones Sanitarias
dc.contributor.funderFundación para la Investigación y la Prevención del Sida en España
dc.contributor.funderInstituto de Salud Carlos III - ISCIII
dc.contributor.funderEuropean Regional Development Fund (ERDF/FEDER)
dc.identifier.journalJournal of Translational Medicine
dc.repisalud.centroISCIII::Centro Nacional de Microbiología::Área de Patología Molecular::Unidad de Infección viral e Inmunidad

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