dc.contributor.author | Perez-de-Llano, Luis | |
dc.contributor.author | García-Cosío, Borja | |
dc.contributor.author | CHACOS Study Grp | |
dc.date.accessioned | 2024-07-11T09:10:46Z | |
dc.date.available | 2024-07-11T09:10:46Z | |
dc.date.issued | 2017-11-02 | |
dc.identifier.citation | Perez-De-Llano L, Cosio BG, CHACOS Study Grp. Asthma-COPD overlap is not a homogeneous disorder: further supporting data. Respir Res. 2017 Nov 02;18:183. | en |
dc.identifier.issn | 1465-993X | |
dc.identifier.other | http://hdl.handle.net/20.500.13003/9560 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/20462 | |
dc.description.abstract | Asthma-COPD ovelap (ACO) is an umbrella term that encompasses patients with COPD and eosinophilic inflammation (e-COPD) and smoking asthmatics with non-fully reversible airflow obstruction (SA). We compared the clinical characteristics and the inflammatory profile of e-COPD and SA. Patients classified as e-COPD were older and more often male and showed significantly impaired pulmonary function (likely explained by a heavier smoking habit). On the contrary, SA had more atopic features, more reversibility of airflow obstruction and higher IgE levels. The concentrations of IL-5, IL-13, IL-8, IL-6, TNF-alpha, IL17 in serum were similar between the 2 groups. However, Th2-related biomarkers (periostin, FeNO and blood eosinophils) shower higher median values in e-COPD patients. Our findings reinforce the notion that ACO is a heterogeneous disorder and, as a consequence, it might be unacceptable to offer the same treatment for two related but different conditions. | en |
dc.description.sponsorship | The project was endorsed by the COPD and Asthma Research Board (PII de EPOC y asma) of the Spanish Society of Pneumology and Thoracic Surgery (SEPAR). The project was partially funded by the Fondo de Investigaciones Sanitarias, Instituto de Salud Carlos III, Ministerio de Economia y Competitividad (FIS 15/01263) and by an unrestricted grant from Chiesi Espana S.A.U. | es_ES |
dc.language.iso | eng | en |
dc.publisher | BioMed Central (BMC) | en |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Eosinophils | |
dc.subject | Periostin | |
dc.subject | COPD | |
dc.subject | Asthma | |
dc.subject | Asthma-COPD overlap | |
dc.subject | ACO | |
dc.subject.mesh | Asthma | * |
dc.subject.mesh | Eosinophils | * |
dc.subject.mesh | Aged | * |
dc.subject.mesh | Male | * |
dc.subject.mesh | Inflammation Mediators | * |
dc.subject.mesh | Female | * |
dc.subject.mesh | Pulmonary Disease, Chronic Obstructive | * |
dc.subject.mesh | Humans | * |
dc.subject.mesh | Forced Expiratory Volume | * |
dc.subject.mesh | Middle Aged | * |
dc.subject.mesh | Cross-Sectional Studies | * |
dc.title | Asthma-COPD overlap is not a homogeneous disorder: further supporting data | en |
dc.type | research article | en |
dc.rights.license | Attribution 4.0 International | * |
dc.identifier.pubmedID | 29096609 | es_ES |
dc.format.volume | 18 | es_ES |
dc.format.page | 183 | es_ES |
dc.identifier.doi | 10.1186/s12931-017-0667-x | |
dc.identifier.e-issn | 1465-9921 | es_ES |
dc.relation.publisherversion | https://dx.doi.org/10.1186/s12931-017-0667-x | en |
dc.identifier.journal | Respiratory Research | es_ES |
dc.rights.accessRights | open access | en |
dc.subject.decs | Estudios Transversales | * |
dc.subject.decs | Volumen Espiratorio Forzado | * |
dc.subject.decs | Enfermedad Pulmonar Obstructiva Crónica | * |
dc.subject.decs | Humanos | * |
dc.subject.decs | Mediadores de Inflamación | * |
dc.subject.decs | Persona de Mediana Edad | * |
dc.subject.decs | Anciano | * |
dc.subject.decs | Asma | * |
dc.subject.decs | Eosin�filos | * |
dc.subject.decs | Femenino | * |
dc.subject.decs | Masculino | * |
dc.identifier.scopus | 2-s2.0-85032744946 | |
dc.identifier.wos | 414334100002 | |
dc.identifier.pui | L619046921 | |