dc.contributor.author | Manzano-Salgado, Cyntia B | |
dc.contributor.author | Casas, Maribel | |
dc.contributor.author | Lopez-Espinosa, Maria-Jose | |
dc.contributor.author | Ballester, Ferran | |
dc.contributor.author | Iniguez, Carmen | |
dc.contributor.author | Martinez, David | |
dc.contributor.author | Romaguera, Dora | |
dc.contributor.author | Fernandez-Barres, Silvia | |
dc.contributor.author | Santa-Marina, Loreto | |
dc.contributor.author | Basterretxea, Mikel | |
dc.contributor.author | Schettgen, Thomas | |
dc.contributor.author | Valvi, Damaskini | |
dc.contributor.author | | |
dc.contributor.author | Sunyer, Jordi | |
dc.contributor.author | Vrijheid, Martine | |
dc.date.accessioned | 2024-07-11T09:10:41Z | |
dc.date.available | 2024-07-11T09:10:41Z | |
dc.date.issued | 2017-09 | |
dc.identifier.citation | Manzano-Salgado CB, Casas M, Lopez-Espinosa MJ, Ballester F, Iniguez C, Martinez D, et al. Prenatal Exposure to Perfluoroalkyl Substances and Cardiometabolic Risk in Children from the Spanish INMA Birth Cohort Study. Environ Health Perspect. 2017 Sep;125(9):97018. | en |
dc.identifier.issn | 0091-6765 | |
dc.identifier.other | http://hdl.handle.net/20.500.13003/9689 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/20451 | |
dc.description.abstract | BACKGROUND: Perfluoroalkyl substances (PFAS) may affect body mass index (BMI) and other components of cardiometabolic (CM) risk during childhood, hut evidence is scarce and inconsistent. OBJECTIVES: We estimated associations between prenatal PFAS exposures and outcomes relevant to cardiometabolic risk, including a composite CM risk score. METHODS: We measured perfluorohexanesulfonic acid (PFHxS), perfluorooctanesulfonic acid (PFOS), perfluorooctanoic acid (PFOA), and perfluorononanoic acid (PFNA) in maternal plasma (first trimester). We assessed weight gain from birth until 6 mo. At 4 and 7 y, we calculated the age- and sex-specific z-scores for BMI, waist circumference (WC), and blood pressure (BP) (n approximate to 1,000). At age 4, we calculated the age-, sex-, and region specific z-scores for cholesterol, triglycerides (TGs), high-density (HDL-C), and low-density lipoprotein cholesterol (LDL-C) (n = 627). At age 4, we calculated a CM-risk score (n = 386) as the sum of the individual age-, sex-, and region-specific z-scores for WC, BP, HDL-C, and TGs. We used the average between the negative of HDE-C z-score and TGs z-score to give similar weight to lipids and the other components in the score. A higher score indicates a higher cardiometaholic risk at age 4. RESULTS: PFOS and PFOA were the most abundant PFAS (geometric mean: 5.80 and 2.32 ng/mL respectively). In general, prenatal PFAS concentrations were not associated with individual outcomes or the combined CM-risk score. Exceptions were positive associations between prenatal PFHxS and TGs z-score [for a doubling of exposure, beta = 0.11; 95% confidence interval (CI): 0.01, 0.21], and between PFNA and the CM-risk score (beta=0.60; 95% CI: 0.04, 1.16). There was not clear or consistent evidence of modification by sex. CONCLUSIONS: We observed little or no evidence of associations between low prenatal PFAS exposures and outcomes related to cardiometabolic risk in a cohort of Spanish children followed from birth until 7 y. | en |
dc.description.sponsorship | This study was funded by grants from the European Union (FP7-ENV-2011 cod 282957 and HEALTH.2010.2.4.5-1), and from Spain: Instituto de Salud Carlos III and Ministry of Health (Red INMA G03/176; CB06/02/0041; PI041436, PI081151, PI06/0867, PS09/00090, PI13/02187; FIS-FEDER: PI03/1615, P104/1509, PI04/1112, PI04/1931, PI05/1079, PI05/1052, PI06/1213, P107/0314, PI09/02647, PH 1/01007, PI11/02591, P111/02038, P112/01890, PI13/1944, PI13/2032, P114/00891, and PI14/1687; predoctoral grant PETS - F114/00099; and Miguel Servet-FEDER: CP11/0178 and CP1116/00051), CIBERESP; the Conselleria de Sanitat, Generalitat Valenciana; Department of Health of the Basque Government (2005111093 and 2009111069); the Provincial Government of Gipuzkoa (DEG06/004 and DEG08/001); and the Gcneralitat de Catalunya-CIRIT (1999SGR 00241); and from the United Stated of America: National Institute of Environmental Health Sciences of the National Institutes of Health (NIH) (grant number ES021477). ISGlobal is a member of the Centres de Recerca de Catalunya (CERCA) Programme, Generalitat de Catalunya. This study has been reviewed and approved by the accredited committees of the following institutions: the Municipal Institute of Sanitary Assistance of Barcelona, La Fe University Hospital of Valencia, and Donostia Hospital de Zumarraga. | es_ES |
dc.language.iso | eng | en |
dc.publisher | Us Dept Health Human Sciences Public Health Science | en |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject.mesh | Child | * |
dc.subject.mesh | Spain | * |
dc.subject.mesh | Adult | * |
dc.subject.mesh | Environmental Pollutants | * |
dc.subject.mesh | Humans | * |
dc.subject.mesh | Environmental Exposure | * |
dc.subject.mesh | Fluorocarbons | * |
dc.subject.mesh | Caprylates | * |
dc.subject.mesh | Pregnancy | * |
dc.subject.mesh | Male | * |
dc.subject.mesh | Alkanesulfonic Acids | * |
dc.subject.mesh | Female | * |
dc.subject.mesh | Maternal Exposure | * |
dc.subject.mesh | Prenatal Exposure Delayed Effects | * |
dc.title | Prenatal Exposure to Perfluoroalkyl Substances and Cardiometabolic Risk in Children from the Spanish INMA Birth Cohort Study | en |
dc.type | research article | en |
dc.rights.license | Attribution 4.0 International | * |
dc.identifier.pubmedID | 28934720 | es_ES |
dc.format.volume | 125 | es_ES |
dc.format.number | 9 | es_ES |
dc.format.page | 97018 | es_ES |
dc.identifier.doi | 10.1289/EHP1330 | |
dc.identifier.e-issn | 1552-9924 | es_ES |
dc.relation.publisherversion | https://dx.doi.org/10.1289/EHP1330 | en |
dc.identifier.journal | Environmental Health Perspectives | es_ES |
dc.rights.accessRights | open access | en |
dc.subject.decs | Exposición Materna | * |
dc.subject.decs | Femenino | * |
dc.subject.decs | Ácidos Alcanesulfónicos | * |
dc.subject.decs | Exposición a Riesgos Ambientales | * |
dc.subject.decs | Masculino | * |
dc.subject.decs | Contaminantes Ambientales | * |
dc.subject.decs | Fluorocarburos | * |
dc.subject.decs | Caprilatos | * |
dc.subject.decs | Humanos | * |
dc.subject.decs | Embarazo | * |
dc.subject.decs | Niño | * |
dc.subject.decs | Adulto | * |
dc.subject.decs | Efectos Tardíos de la Exposición Prenatal | * |
dc.subject.decs | España | * |
dc.identifier.scopus | 2-s2.0-85031786350 | |
dc.identifier.wos | 413792800028 | |
dc.identifier.pui | L619529577 | |