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dc.contributor.author | Fernandez, Rafael | |
dc.contributor.author | Subira, Carles | |
dc.contributor.author | Frutos-Vivar, Fernando | |
dc.contributor.author | Rialp, Gemma | |
dc.contributor.author | Laborda, Cesar | |
dc.contributor.author | Ramon Masclans, Joan | |
dc.contributor.author | Lesmes, Amanda | |
dc.contributor.author | Panadero, Luna | |
dc.contributor.author | Hernandez, Gonzalo | |
dc.date.accessioned | 2024-07-11T09:10:31Z | |
dc.date.available | 2024-07-11T09:10:31Z | |
dc.date.issued | 2017-05-02 | |
dc.identifier.citation | Fernandez R, Subira C, Frutos-Vivar F, Rialp G, Laborda C, Ramon Masclans J, et al. High-flow nasal cannula to prevent postextubation respiratory failure in high-risk non-hypercapnic patients: a randomized multicenter trial. Ann Intensive Care. 2017 May 02;7:47. Epub 2017 May 2. | en |
dc.identifier.issn | 2110-5820 | |
dc.identifier.other | http://hdl.handle.net/20.500.13003/9834 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/20428 | |
dc.description.abstract | Background: Extubation failure is associated with increased morbidity and mortality, but cannot be safely predicted or avoided. High-flow nasal cannula (HFNC) prevents postextubation respiratory failure in low-risk patients. Objective: To demonstrate that HFNC reduces postextubation respiratory failure in high-risk non-hypercapnic patients compared with conventional oxygen. Methods: Randomized, controlled multicenter trial in patients who passed a spontaneous breathing trial. We enrolled patients meeting criteria for high-risk of failure to randomly receive HFNC or conventional oxygen for 24 h after extubation. Primary outcome was respiratory failure within 72-h postextubation. Secondary outcomes were reintubation, intensive care unit (ICU) and hospital lengths of stay, and mortality. Statistical analysis included multiple logistic regression models. Results: The study was stopped due to low recruitment after 155 patients were enrolled (78 received high-flow and 77 received conventional oxygen). Groups were similar at enrollment, and all patients tolerated 24-h HFNC. Post-extubation respiratory failure developed in 16 (20%) HFNC patients and in 21 (27%) conventional patients [OR 0.69 (0.31-1.54), p = 0.2]. Reintubation was needed in 9 (11%) HFNC patients and in 12 (16%) conventional patients [OR 0.71 (0.25-1.95), p = 0.5]. No difference was found in ICU or hospital length of stay, or mortality. Logistic regression models suggested HFNC [OR 0.43 (0.18-0.99), p = 0.04] and cancer [OR 2.87 (1.04-7.91), p = 0.04] may be independently associated with postextubation respiratory failure. Conclusion: Our study is inconclusive as to a potential benefit of HFNC over conventional oxygen to prevent occurrence of respiratory failure in non-hypercapnic patients at high risk for extubation failure. | en |
dc.description.sponsorship | RF has received fees for conferences by Fisher & Paykel Healthcare. JRM has received a postdoctoral Grant from Fisher & Paykel Healthcare. | es_ES |
dc.language.iso | eng | en |
dc.publisher | Springer | en |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Mechanical ventilation | |
dc.subject | Weaning | |
dc.subject | Reintubation | |
dc.subject | High-flow oxygen | |
dc.title | High-flow nasal cannula to prevent postextubation respiratory failure in high-risk non-hypercapnic patients: a randomized multicenter trial | en |
dc.type | research article | en |
dc.rights.license | Attribution 4.0 International | * |
dc.identifier.pubmedID | 28466461 | es_ES |
dc.format.volume | 7 | es_ES |
dc.format.page | 47 | es_ES |
dc.identifier.doi | 10.1186/s13613-017-0270-9 | |
dc.relation.publisherversion | https://dx.doi.org/10.1186/s13613-017-0270-9 | en |
dc.identifier.journal | Annals of Intensive Care | es_ES |
dc.rights.accessRights | open access | en |
dc.identifier.scopus | 2-s2.0-85018978960 | |
dc.identifier.wos | 404770600002 | |
dc.identifier.pui | L615855054 |
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