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dc.contributor.author | Garcia-Layana, Alfredo | |
dc.contributor.author | Ciufo, Gianfranco | |
dc.contributor.author | Toledo, Estefanía | |
dc.contributor.author | Martinez-Gonzalez, Miguel A | |
dc.contributor.author | Corella, Dolores | |
dc.contributor.author | Fito, Montserrat | |
dc.contributor.author | Estruch, Ramon | |
dc.contributor.author | Gomez-Gracia, Enrique | |
dc.contributor.author | ||
dc.contributor.author | Lapetra, Jose | |
dc.contributor.author | Serra-Majem, Lluis | |
dc.contributor.author | Pinto, Xavier | |
dc.contributor.author | Portillo, Maria P | |
dc.contributor.author | Sorli, Jose V | |
dc.contributor.author | Bullo, Monica | |
dc.contributor.author | Vinyoles, Ernest | |
dc.contributor.author | Sala-Vila, Aleix | |
dc.contributor.author | Ros, Emilio | |
dc.contributor.author | Salas-Salvado, Jordi | |
dc.contributor.author | Aros, Fernando | |
dc.date.accessioned | 2024-07-11T09:10:30Z | |
dc.date.available | 2024-07-11T09:10:30Z | |
dc.date.issued | 2017-05 | |
dc.identifier.citation | Garcia-Layana A, Ciufo G, Toledo E, Martinez-Gonzalez MA, Corella D, Fito M, et al. The Effect of a Mediterranean Diet on the Incidence of Cataract Surgery. Nutrients. 2017 May;9(5):453. | en |
dc.identifier.issn | 2072-6643 | |
dc.identifier.other | http://hdl.handle.net/20.500.13003/9862 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/20426 | |
dc.description.abstract | Background: Cataract is a leading cause of vision impairment worldwide, and surgery is the only available treatment. The process that initiates lens opacification is dependent on the oxidative stress experienced by the lens components. A healthy overall dietary pattern, with the potential to reduce oxidative stress, has been suggested as a means to decrease the risk of developing cataract. We aimed to investigate the hypothesis that an intervention with a Mediterranean diet (MedDiet) rather than a low-fat diet could decrease the incidence of cataract surgery in elderly subjects. Methods: We included 5802 men and women (age range: 55-80 years) from the Prevencion con Dieta Mediterronea study (multicenter, parallel-group, randomized controlled clinical trial) who had not undergone cataract surgery. They were randomly assigned to one of three intervention groups: (1) a MedDiet enriched with extra-virgin olive oil (EVOO) (n = 1998); (2) a MedDiet enriched with nuts (n = 1914), and a control group recommended to follow a low-fat diet (n = 1890). The incidence of cataract surgery was recorded yearly during follow-up clinical evaluations. Primary analyses were performed on an intention-to-treat basis. Cox regression analyses were used to assess the relationship between the nutritional intervention and the incidence of cataract surgery. Results: During a follow-up period of 7.0 years (mean follow-up period: 5.7 years; median: 5.9 years), 559 subjects underwent cataract surgery. Two hundred and six participants from the MedDiet + EVOO group, 174 from the MedDiet + Nuts group, and 179 from the control group underwent cataract surgery. We did not observe a reduction in the incidence of cataract surgery in the MedDiet groups compared to the control group. The multivariable adjusted hazard ratios were 1.03 (95% confidence interval [CI]: 0.84-1.26, p = 0.79) for the control group versus the MedDiet + EVOO group and 1.06 (95% CI: 0.86-1.31, p = 0.58) for the control group versus the MedDiet + Nuts group. Conclusions: To our knowledge, this is the first large randomized trial assessing the role of a MedDiet on the incidence of cataract surgery. Our results showed that the incidence of cataract surgery was similar in the MedDiet with EVOO, MedDiet with nuts, and low-fat diet groups. Further studies are necessary to investigate whether a MedDiet could have a preventive role in cataract surgery. | en |
dc.description.sponsorship | Supported by the official funding agency for biomedical research of the Spanish government, Instituto de Salud Carlos III (ISCIII), through grants provided to research networks specifically developed for the trial (RTIC G03/140, to Ramon Estruch; RTIC RD 06/0045, to Miguel Martinez-Gonzalez and through Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y Nutricion [CIBEROBN]), and by grants from Centro Nacional de Investigaciones Cardiovasculares (CNIC 06/2007), Fondo de Investigacion Sanitaria-Fondo Europeo de Desarrollo Regional (PI04-2239, PI 05/2584, CP06/00100, PI07/0240, PI07/1138, PI07/0954, PI 07/0473, PI10/01407, PI10/02658, PI11/01647, and P11/02505; PI13/00462), Ministerio de Ciencia e Innovacion (AGL-2009-13906-C02 and AGL2010-22319-C03), Fundacion Mapfre 2010, Consejeria de Salud de la Junta de Andalucia (PI0105/2007), Public Health Division of the Department of Health of the Autonomous Government of Catalonia, Generalitat Valenciana (ACOMP06109, GVA-COMP2010-181, GVACOMP2011-151, CS2010-AP-111, and CS2011-AP-042), and Regional Government of Navarra (P27/2011). AS-V holds a Miguel Servet I contract (CP12/03299), ISCIII, Spain. | es_ES |
dc.language.iso | eng | en |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | en |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Mediterranean diet | |
dc.subject | PREDIMED | |
dc.subject | Cataract | |
dc.subject | Cataract surgery | |
dc.subject | Nuts | |
dc.subject | Extra-virgin olive oil | |
dc.subject | Low-fat diet | |
dc.subject | Antioxidants | |
dc.subject.mesh | Aged, 80 and over | * |
dc.subject.mesh | Aged | * |
dc.subject.mesh | Follow-Up Studies | * |
dc.subject.mesh | Humans | * |
dc.subject.mesh | Middle Aged | * |
dc.subject.mesh | Nuts | * |
dc.subject.mesh | Cataract | * |
dc.subject.mesh | Male | * |
dc.subject.mesh | Patient Compliance | * |
dc.subject.mesh | Female | * |
dc.subject.mesh | Risk Factors | * |
dc.subject.mesh | Treatment Outcome | * |
dc.subject.mesh | Diet, Mediterranean | * |
dc.subject.mesh | Diet, Fat-Restricted | * |
dc.subject.mesh | Olive Oil | * |
dc.subject.mesh | Incidence | * |
dc.title | The Effect of a Mediterranean Diet on the Incidence of Cataract Surgery | en |
dc.type | research article | en |
dc.rights.license | Attribution 4.0 International | * |
dc.identifier.pubmedID | 28467363 | es_ES |
dc.format.volume | 9 | es_ES |
dc.format.number | 5 | es_ES |
dc.format.page | 453 | es_ES |
dc.identifier.doi | 10.3390/nu9050453 | |
dc.relation.publisherversion | https://dx.doi.org/10.3390/nu9050453 | en |
dc.identifier.journal | Nutrients | es_ES |
dc.rights.accessRights | open access | en |
dc.subject.decs | Dieta Mediterránea | * |
dc.subject.decs | Dieta con Restricción de Grasas | * |
dc.subject.decs | Incidencia | * |
dc.subject.decs | Resultado del Tratamiento | * |
dc.subject.decs | Femenino | * |
dc.subject.decs | Aceite de Oliva | * |
dc.subject.decs | Masculino | * |
dc.subject.decs | Estudios de Seguimiento | * |
dc.subject.decs | Catarata | * |
dc.subject.decs | Cooperación del Paciente | * |
dc.subject.decs | Factores de Riesgo | * |
dc.subject.decs | Humanos | * |
dc.subject.decs | Persona de Mediana Edad | * |
dc.subject.decs | Nueces | * |
dc.subject.decs | Anciano | * |
dc.subject.decs | Anciano de 80 o más Años | * |
dc.identifier.scopus | 2-s2.0-85019024055 | |
dc.identifier.wos | 402054500031 | |
dc.identifier.pui | L615957259 |
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