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dc.contributor.author | Ziberna, Lovro | |
dc.contributor.author | Samec, Dunja | |
dc.contributor.author | Mocan, Andrei | |
dc.contributor.author | Nabavi, Seyed Fazel | |
dc.contributor.author | Bishayee, Anupam | |
dc.contributor.author | Farooqi, Ammad Ahmad | |
dc.contributor.author | Soldevila Verdeguer, Carla | |
dc.contributor.author | Nabavi, Seyed Mohammad | |
dc.date.accessioned | 2024-07-11T09:07:40Z | |
dc.date.available | 2024-07-11T09:07:40Z | |
dc.date.issued | 2017-03 | |
dc.identifier.citation | Ziberna L, Samec D, Mocan A, Nabavi Seyed F, Bishayee A, Farooqi Ammad A, et al. Oleanolic Acid Alters Multiple Cell Signaling Pathways: Implication in Cancer Prevention and Therapy. Int J Mol Sci. 2017 Mar;18(3):643. | en |
dc.identifier.issn | 1422-0067 | |
dc.identifier.other | http://hdl.handle.net/20.500.13003/9935 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/20413 | |
dc.description.abstract | Nowadays, much attention has been paid to diet and dietary supplements as a cost-effective therapeutic strategy for prevention and treatment of a myriad of chronic and degenerative diseases. Rapidly accumulating scientific evidence achieved through high-throughput technologies has greatly expanded the understanding about the multifaceted nature of cancer. Increasingly, it is being realized that deregulation of spatio-temporally controlled intracellular signaling cascades plays a contributory role in the onset and progression of cancer. Therefore, targeting regulators of oncogenic signaling cascades is essential to prevent and treat cancer. A plethora of preclinical and epidemiological evidences showed promising role of phytochemicals against several types of cancer. Oleanolic acid, a common pentacyclic triterpenoid, is mainly found in olive oil, as well as several plant species. It is a potent inhibitor of cellular inflammatory process and a well-known inducer of phase 2 xenobiotic biotransformation enzymes. Main molecular mechanisms underlying anticancer effects of oleanolic acid are mediated by caspases, 5' adenosine monophosphate-activated protein kinase, extracellular signal-regulated kinase 1/2, matrix metalloproteinases, pro-apoptotic Bax and bid, phosphatidylinositide 3-kinase/Akt1/mechanistic target of rapamycin, reactive oxygen species/apoptosis signal-regulating kinase 1/p38 mitogen-activated protein kinase, nuclear factor-kappa B, cluster of differentiation 1, CKD4, s6k, signal transducer and activator of transcription 3, as well as aforementioned signaling pathways. In this work, we critically review the scientific literature on the molecular targets of oleanolic acid implicated in the prevention and treatment of several types of cancer. We also discuss chemical aspects, natural sources, bioavailability, and safety of this bioactive phytochemical. | en |
dc.description.sponsorship | This article is the outcome of an in-house financially non-supported study. A. Sureda was partially supported by the Spanish Ministry of Health, Social Services and Equality (CIBEROBN-CB12/03/ 30038). | es_ES |
dc.language.iso | eng | en |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | en |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Oleanolic acid | |
dc.subject | Olive | |
dc.subject | Anticancer effect | |
dc.subject | Signaling pathways | |
dc.subject | Healthy diet | |
dc.subject.mesh | Oleanolic Acid | * |
dc.subject.mesh | Animals | * |
dc.subject.mesh | Humans | * |
dc.subject.mesh | Signal Transduction | * |
dc.subject.mesh | Antineoplastic Agents | * |
dc.subject.mesh | Neoplasms | * |
dc.title | Oleanolic Acid Alters Multiple Cell Signaling Pathways: Implication in Cancer Prevention and Therapy | en |
dc.type | review article | en |
dc.rights.license | Attribution 4.0 International | * |
dc.identifier.pubmedID | 28300756 | es_ES |
dc.format.volume | 18 | es_ES |
dc.format.number | 3 | es_ES |
dc.format.page | 643 | es_ES |
dc.identifier.doi | 10.3390/ijms18030643 | |
dc.relation.publisherversion | https://dx.doi.org/10.3390/ijms18030643 | en |
dc.identifier.journal | International Journal of Molecular Sciences | es_ES |
dc.rights.accessRights | open access | en |
dc.subject.decs | Transducción de Señal | * |
dc.subject.decs | Animales | * |
dc.subject.decs | Antineoplásicos | * |
dc.subject.decs | Humanos | * |
dc.subject.decs | Neoplasias | * |
dc.subject.decs | Ácido Oleanólico | * |
dc.identifier.scopus | 2-s2.0-85015741352 | |
dc.identifier.wos | 396253700170 | |
dc.identifier.pui | L614849434 |
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