Mostrar el registro sencillo del ítem
dc.contributor.author | Cunill, Vanesa | |
dc.contributor.author | Clemente, Antonio | |
dc.contributor.author | Lanio, Nallibe | |
dc.contributor.author | Barcelo, Carla | |
dc.contributor.author | Andreu, Valero | |
dc.contributor.author | Pons De Ves, Jaime | |
dc.contributor.author | Ferrer Balaguer, Juana Maria | |
dc.date.accessioned | 2024-07-11T09:07:40Z | |
dc.date.available | 2024-07-11T09:07:40Z | |
dc.date.issued | 2017-02-27 | |
dc.identifier.citation | Cunill Monjo V, Clemente A, Lanio N, Barcelo C, Andreu Matillas V, Pons De Ves J, et al. Follicular T cells from smB(-) common Variable immunodeficiency Patients are skewed Toward a Th1 Phenotype. Front Immunol. 2017 Feb 27;8:174. | en |
dc.identifier.issn | 1664-3224 | |
dc.identifier.other | http://hdl.handle.net/20.500.13003/9941 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/20412 | |
dc.description.abstract | Germinal center follicular T helper (GCTfh) cells are essential players in the differentiation of B cells. Circulating follicular T helper (cTfh) cells share phenotypic and functional properties with GCTfh cells. Distinct subpopulations of cTfh with different helper capabilities toward B cells can be identified: cTfh1 (CXCR3(+)CCR6(-)), cTfh2 (CXCR3(-)CCR6(-)), and cTfh17 (CXCR3(-)CCR6+). Alterations in cTfh function and/or distribution have been associated with autoimmunity, infectious diseases, and more recently, with several monogenic immunodeficiencies. Common variable immunodeficiency (CVID) disease is the commonest symptomatic primary immunodeficiency with a genetic cause identified in only 2-10% of patients. Although a heterogeneous disease, most patients show a characteristic defective B cell differentiation into memory B cells or antibody-secreting cells. We investigated if alterations in CVID cTfh cells frequency or distribution into cTfh1, cTfh2, and cTfh17 subpopulations and regulatory follicular T (Tfr) cells could be related to defects in CVID B cells. We found increased percentages of cTfh exhibiting higher programmed death-1 expression and altered subpopulations distribution in smB(-) CVID patients. In contrast to smB(+) patients and controls, cTfh from smB-CVID patients show increased cTfh1 and decreased cTfh17 subpopulation percentages and increased CXCR3(+)CCR6(+) cTfh, a population analogous to the recently described pathogenic Th17.1. Moreover, Tfr cells are remarkably decreased only in smB-CVID patients. In conclusion, increased cTfh17.1 and cTfh1/cTfh17 ratio in CVID patients could influence B cell fate in smB-CVID patients, with a more compromised B cell compartment, and the decrease in Tfr cells may lead to high risk of autoimmune conditions in CVID patients. | en |
dc.description.sponsorship | This work has been supported by the Fondo de Investigacion Sanitaria (grant number: FIS PI14/00265) from the Instituto de Salud Carlos III (Spanish Government) and the Fondo Europeo de Desarrollo Regional (FEDER). | es_ES |
dc.language.iso | eng | en |
dc.publisher | Frontiers Media | en |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | B cells | |
dc.subject | CVID | |
dc.subject | Follicular T helper cells | |
dc.subject | Regulatory follicular T cells | |
dc.subject | Th17.1 cells | |
dc.title | Follicular T cells from smB(-) common Variable immunodeficiency Patients are skewed Toward a Th1 Phenotype | en |
dc.type | research article | en |
dc.rights.license | Attribution 4.0 International | * |
dc.identifier.pubmedID | 28289412 | es_ES |
dc.format.volume | 8 | es_ES |
dc.format.page | 174 | es_ES |
dc.identifier.doi | 10.3389/fimmu.2017.00174 | |
dc.relation.publisherversion | https://dx.doi.org/10.3389/fimmu.2017.00174 | en |
dc.identifier.journal | Frontiers in Immunology | es_ES |
dc.rights.accessRights | open access | en |
dc.identifier.scopus | 2-s2.0-85014309654 | |
dc.identifier.wos | 394810200001 | |
dc.identifier.pui | L614636597 |
Ficheros en el ítem
Ficheros | Tamaño | Formato | Ver |
---|---|---|---|
No hay ficheros asociados a este ítem. |