Mostrar el registro sencillo del ítem
dc.contributor.author | Ng, Melissa S F | |
dc.contributor.author | Kwok, Immanuel | |
dc.contributor.author | Tan, Leonard | |
dc.contributor.author | Shi, Changming | |
dc.contributor.author | Cerezo-Wallis, Daniela | |
dc.contributor.author | Tan, Yingrou | |
dc.contributor.author | Leong, Keith | |
dc.contributor.author | Calvo, Gabriel F | |
dc.contributor.author | Yang, Katharine | |
dc.contributor.author | Zhang, Yuning | |
dc.contributor.author | Jin, Jingsi | |
dc.contributor.author | Liong, Ka Hang | |
dc.contributor.author | Wu, Dandan | |
dc.contributor.author | He, Rui | |
dc.contributor.author | Liu, Dehua | |
dc.contributor.author | Teh, Ye Chean | |
dc.contributor.author | Bleriot, Camille | |
dc.contributor.author | Caronni, Nicoletta | |
dc.contributor.author | Liu, Zhaoyuan | |
dc.contributor.author | Duan, Kaibo | |
dc.contributor.author | Narang, Vipin | |
dc.contributor.author | Ballesteros, Iván | |
dc.contributor.author | Moalli, Federica | |
dc.contributor.author | Li, Mengwei | |
dc.contributor.author | Chen, Jinmiao | |
dc.contributor.author | Liu, Yao | |
dc.contributor.author | Liu, Lianxin | |
dc.contributor.author | Qi, Jingjing | |
dc.contributor.author | Liu, Yingbin | |
dc.contributor.author | Jiang, Lingxi | |
dc.contributor.author | Shen, Baiyong | |
dc.contributor.author | Cheng, Hui | |
dc.contributor.author | Cheng, Tao | |
dc.contributor.author | Angeli, Veronique | |
dc.contributor.author | Sharma, Ankur | |
dc.contributor.author | Loh, Yuin-Han | |
dc.contributor.author | Tey, Hong Liang | |
dc.contributor.author | Chong, Shu Zhen | |
dc.contributor.author | Iannacone, Matteo | |
dc.contributor.author | Ostuni, Renato | |
dc.contributor.author | Hidalgo, Andrés | |
dc.contributor.author | Ginhoux, Florent | |
dc.contributor.author | Ng, Lai Guan | |
dc.date.accessioned | 2024-07-09T15:09:26Z | |
dc.date.available | 2024-07-09T15:09:26Z | |
dc.date.issued | 2024-01-12 | |
dc.identifier.citation | Science. 2024 Jan 12;383(6679):eadf6493. | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/20369 | |
dc.description.abstract | Neutrophils are increasingly recognized as key players in the tumor immune response and are associated with poor clinical outcomes. Despite recent advances characterizing the diversity of neutrophil states in cancer, common trajectories and mechanisms governing the ontogeny and relationship between these neutrophil states remain undefined. Here, we demonstrate that immature and mature neutrophils that enter tumors undergo irreversible epigenetic, transcriptional, and proteomic modifications to converge into a distinct, terminally differentiated dcTRAIL-R1+ state. Reprogrammed dcTRAIL-R1+ neutrophils predominantly localize to a glycolytic and hypoxic niche at the tumor core and exert pro-angiogenic function that favors tumor growth. We found similar trajectories in neutrophils across multiple tumor types and in humans, suggesting that targeting this program may provide a means of enhancing certain cancer immunotherapies. | es_ES |
dc.description.sponsorship | This research was funded by Singapore Immunology Network (SIgN) core funding and A*STAR, Singapore. L.G.N. is supported by National Natural Science Foundation of China (grant 32270956) and Shanghai Science and Technology Commission (grant 20JC1410100). M.S.F. is supported by the A*STAR Career Development Fund (grant 202D8150). I.W.K. is supported by the A*STAR Career Development Fund (grant 202D8197). S.Z.C. is supported by the A*STAR Career Development Award (192D8043) and core funding from SIgN. Y.T. and H.L.T. are supported by Clinician Scientist Awards (NMRC/CSA-INV/0023/2017 and CSAINV20nov-0003) from the National Medical Research Council of Singapore. The SIgN Flow Cytometry facility is supported by National Research Foundation (NRF) Singapore under Shared Infrastructure Support (SIS) (NRF2017_SISFP09). For the use of the Ultramicroscope II, we would like to thank A*STAR core funds, the HMBS IAF-PP grant (H1701a0004), and the National Research Foundation’s Shared Infrastructure Support grant for SingaScope, a Singapore-wide microscopy infrastructure network (NRF2017_SISFP10), for continued support of the A*STAR Microscopy Platform. D.C.-W. is supported by a CRI Irvington postdoctoral fellowship (CRI3511). G.F.C. is supported by grant PID2022-142341OB-I00 funded by the Spanish MCIN/AEI/ 10.13039/501100011033. I.B. is supported by a Ramon y Cajal fellowship (RYC2021-033511-I) from MICINN and by a Leonardo fellowship (LEO22-2-2596) from the BBVA Foundation. A.V. and Y.Z. are supported by NMRC OF-IRG grant to VA (OFIRG19nov-0112). M.I. is supported by the European Research Council (ERC) Consolidator Grant 725038, ERC Proof of Concept Grants 957502 and 101138728, Italian Association for Cancer Research (AIRC) Grants 19891 and 22737, Italian Ministry for University and Research Grants PE00000007 (INF-ACT) and PRIN (2022FMESXL), and by a Funded Research Agreement from Asher Biotherapeutics and VIR Biotechnology. A.H. is supported by grant R01AI165661 from NIH/NIAD, RTI2018-095497- B-I00 from MCIN, HR17_00527 from Fundación La Caixa, the Transatlantic Network of Excellence (TNE-18CVD04) from the Leducq Foundation, and FET-OPEN (grant 861878) from the European Commission. The CNIC is supported by the MCIN and the Pro CNIC Foundation and is a Severo Ochoa Center of Excellence (CEX2020-001041-S). F.G. is supported by Singapore Immunology UIBR award from the Agency for Science, Technology and Research (A*STAR), a Singapore NRF Senior Investigatorship (NRFI2017-02), the Fondation Gustave Roussy, and the ARC Foundation. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | American Association for the Advancement of Science (AAAS) | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject.mesh | Neoplasms | es_ES |
dc.subject.mesh | Neutrophils | es_ES |
dc.subject.mesh | Cellular Reprogramming | es_ES |
dc.subject.mesh | Neovascularization, Pathologic | es_ES |
dc.subject.mesh | Humans | es_ES |
dc.subject.mesh | Proteomics | es_ES |
dc.subject.mesh | Receptors, TNF-Related Apoptosis-Inducing Ligand | es_ES |
dc.subject.mesh | Epigenesis, Genetic | es_ES |
dc.subject.mesh | Hypoxia | es_ES |
dc.subject.mesh | Transcription, Genetic | es_ES |
dc.title | Deterministic reprogramming of neutrophils within tumors. | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.identifier.pubmedID | 38207030 | es_ES |
dc.format.volume | 383 | es_ES |
dc.format.number | 6679 | es_ES |
dc.format.page | eadf6493 | es_ES |
dc.identifier.doi | 10.1126/science.adf6493 | es_ES |
dc.contributor.funder | Singapore Immunology Network | es_ES |
dc.contributor.funder | National Natural Science Foundation of China | es_ES |
dc.contributor.funder | Shanghai Science and Technology Commission | es_ES |
dc.contributor.funder | National Medical Research Council of Singapore | es_ES |
dc.contributor.funder | Ministerio de Ciencia e Innovación (España) | es_ES |
dc.contributor.funder | Fundación BBVA | es_ES |
dc.contributor.funder | Unión Europea. Comisión Europea. European Research Council (ERC) | es_ES |
dc.contributor.funder | Fundación La Caixa | es_ES |
dc.contributor.funder | Fondation Leducq | es_ES |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 1095-9203 | es_ES |
dc.relation.publisherversion | 10.1126/science.adf6493 | es_ES |
dc.identifier.journal | Science (New York, N.Y.) | es_ES |
dc.repisalud.orgCNIC | CNIC::Grupos de investigación::Imagen de la Inflamación Cardiovascular y la Respuesta Inmune | es_ES |
dc.repisalud.institucion | CNIC | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/ERC/CoG/725038 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/ERC/957502 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/ERC/101138728 | es_ES |
dc.rights.accessRights | open access | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/PID2022-142341OB-I00 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/MCIN/AEI/10.13039/501100011033 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/RYC2021-033511-I | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/LEO22-2-2596 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/RTI2018-095497- B-I00 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/HR17/00527 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/CEX2020-001041-S | es_ES |