Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/20369
Título
Deterministic reprogramming of neutrophils within tumors.
Autor(es)
Ng, Melissa S F | Kwok, Immanuel | Tan, Leonard | Shi, Changming | Cerezo-Wallis, Daniela | Tan, Yingrou | Leong, Keith | Calvo, Gabriel F | Yang, Katharine | Zhang, Yuning | Jin, Jingsi | Liong, Ka Hang | Wu, Dandan | He, Rui | Liu, Dehua | Teh, Ye Chean | Bleriot, Camille | Caronni, Nicoletta | Liu, Zhaoyuan | Duan, Kaibo | Narang, Vipin | Ballesteros, Iván | Moalli, Federica | Li, Mengwei | Chen, Jinmiao | Liu, Yao | Liu, Lianxin | Qi, Jingjing | Liu, Yingbin | Jiang, Lingxi | Shen, Baiyong | Cheng, Hui | Cheng, Tao | Angeli, Veronique | Sharma, Ankur | Loh, Yuin-Han | Tey, Hong Liang | Chong, Shu Zhen | Iannacone, Matteo | Ostuni, Renato | Hidalgo, Andrés | Ginhoux, Florent | Ng, Lai Guan
Fecha de publicación
2024-01-12
Cita
Science. 2024 Jan 12;383(6679):eadf6493.
Idioma
Inglés
Tipo de documento
journal article
Resumen
Neutrophils are increasingly recognized as key players in the tumor immune response and are associated with poor clinical outcomes. Despite recent advances characterizing the diversity of neutrophil states in cancer, common trajectories and mechanisms governing the ontogeny and relationship between these neutrophil states remain undefined. Here, we demonstrate that immature and mature neutrophils that enter tumors undergo irreversible epigenetic, transcriptional, and proteomic modifications to converge into a distinct, terminally differentiated dcTRAIL-R1+ state. Reprogrammed dcTRAIL-R1+ neutrophils predominantly localize to a glycolytic and hypoxic niche at the tumor core and exert pro-angiogenic function that favors tumor growth. We found similar trajectories in neutrophils across multiple tumor types and in humans, suggesting that targeting this program may provide a means of enhancing certain cancer immunotherapies.
MESH
Neoplasms | Neutrophils | Cellular Reprogramming | Neovascularization, Pathologic | Humans | Proteomics | Receptors, TNF-Related Apoptosis-Inducing Ligand | Epigenesis, Genetic | Hypoxia | Transcription, Genetic
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