dc.contributor.author | Baena-Diez, Jose Miguel | |
dc.contributor.author | Penafiel, Judit | |
dc.contributor.author | Subirana, Isaac | |
dc.contributor.author | Ramos-Asensio, Rafael | |
dc.contributor.author | Elosua, Roberto | |
dc.contributor.author | Marin-Ibanez, Alejandro | |
dc.contributor.author | Guembe, Maria Jesus | |
dc.contributor.author | Reigada Mendez, Rebeca | |
dc.contributor.author | Tormo-Diaz, Maria Jose | |
dc.contributor.author | Moreno-Iribas, Conchi | |
dc.contributor.author | Cabre, Joan Josep | |
dc.contributor.author | Segura, Antonio | |
dc.contributor.author | Garcia-Lareo, Manel | |
dc.contributor.author | Gomez de la Carnara, Agustin | |
dc.contributor.author | Lapetra, Jose | |
dc.contributor.author | Quesada, Miguel | |
dc.contributor.author | Marrugat, Jaume | |
dc.contributor.author | Medrano, Maria Jose | |
dc.contributor.author | Berjon, Jesus | |
dc.contributor.author | Frontera-Juan, Guillem | |
dc.contributor.author | Gavrila, Diana | |
dc.contributor.author | Barricarte, Aurelio | |
dc.contributor.author | Basora, Josep | |
dc.contributor.author | Garcia, Jose Maria | |
dc.contributor.author | Pavone, Natalia C | |
dc.contributor.author | Lora-Pablos, David | |
dc.contributor.author | Mayora, Eduardo | |
dc.contributor.author | Franch, Josep | |
dc.contributor.author | Mata, Manel | |
dc.contributor.author | Castell, Conxa | |
dc.contributor.author | Frances, Albert | |
dc.contributor.author | Grau, Maria | |
dc.contributor.author | FRESCO Investigators | |
dc.date.accessioned | 2024-07-09T09:14:38Z | |
dc.date.available | 2024-07-09T09:14:38Z | |
dc.date.issued | 2016-11 | |
dc.identifier.citation | Miguel Baena-Diez Jose, Penafiel Judit, Subirana Isaac, Ramos Rafel, Elosua Roberto, Marin-Ibanez Alejandro, et al. Risk of Cause-Specific Death in Individuals With Diabetes: A Competing Risks Analysis. Diabetes Care. 2016 Nov;39(11):1987-1995. Epub 2016 Aug 4. | en |
dc.identifier.issn | 0149-5992 | |
dc.identifier.other | http://hdl.handle.net/20.500.13003/10113 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/20315 | |
dc.description.abstract | OBJECTIVE: Diabetes is a common cause of shortened life expectancy. We aimed to assess the association between diabetes and cause-specific death. RESEARCH DESIGN AND METHODS: We used the pooled analysis of individual data from 12 Spanish population cohorts with 10-year follow-up. Participants had no previous history of cardiovascular diseases and were 35-79 years old. Diabetes status was self-reported or defined as glycemia >125 mg/dL at baseline. Vital status and causes of death were ascertained by medical records review and linkage with the official death registry. The hazard ratios and cumulative mortality function were assessed with two approaches, with and without competing risks: proportional subdistribution hazard (PSH) and cause-specific hazard (CSH), respectively. Multivariate analyses were fitted for cardiovascular, cancer, and noncardiovascular noncancer deaths. RESULTS: We included 55,292 individuals (15.6% with diabetes and overall mortality of 9.1%). The adjusted hazard ratios showed that diabetes increased mortality risk: 1) cardiovascular death, CSH = 2.03 (95% CI 1.63-2.52) and PSH = 1.99 (1.60-2.49) in men; and CSH = 2.28 (1.75-2.97) and PSH = 2.23 (1.70-2.91) in women; 2) cancer death, CSH = 1.37 (1.13-1.67) and PSH = 1.35 (1.10-1.65) in men; and CSH = 1.68 (1.29-2.20) and PSH = 1.66 (1.25-2.19) in women; and 3) noncardiovascular non cancer death, CSH = 1.53 (1.23-1.91) and PSH = 1.50 (1.20-1.89) in men; and CSH = 1.89 (1.43-2.48) and PSH = 1.84 (1.39-2.45) in women. In all instances, the cumulative mortality function was significantly higher in individuals with diabetes. CONCLUSIONS: Diabetes is associated with premature death from cardiovascular disease, cancer, and noncardiovascular noncancer causes. The use of CSH and PSH provides a comprehensive view of mortality dynamics in a population with diabetes. | en |
dc.description.sponsorship | This work was supported by MARATO TV3 (081630), Institute de Salud Carlos III-Fondo Europeo de Desarrollo Regional-European Regions Development Funds (Red de Investigacion Cardiovascular RD12/0042 [Programa HERACLES], Red RedIAPP RD12/0005, RD06/0018, PI081327, and PI1101801), Agency for Management of University and Research Grants (2014 SGR 240), Consortium for Biomedical Research in Epidemiology and Public Health, and Consortium for Biomedical Research in Obesity and Nutrition. M.G. was supported by the Instituto de Salud Carlos III-Fondo Europeo de Desarrollo Regional-European Regions Development Fund FEDER (FIS CP12/03287). | es_ES |
dc.language.iso | eng | en |
dc.publisher | American Diabetes Association (ADA) | en |
dc.type.hasVersion | SMUR | es_ES |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | * |
dc.subject.mesh | Cardiovascular Diseases | * |
dc.subject.mesh | Diabetes Mellitus, Type 2 | * |
dc.subject.mesh | Aged | * |
dc.subject.mesh | Blood Glucose | * |
dc.subject.mesh | Adult | * |
dc.subject.mesh | Diabetes Mellitus, Type 1 | * |
dc.subject.mesh | Risk Assessment | * |
dc.subject.mesh | Follow-Up Studies | * |
dc.subject.mesh | Humans | * |
dc.subject.mesh | Cause of Death | * |
dc.subject.mesh | Life Expectancy | * |
dc.subject.mesh | Middle Aged | * |
dc.subject.mesh | Neoplasms | * |
dc.subject.mesh | Male | * |
dc.subject.mesh | Multivariate Analysis | * |
dc.subject.mesh | Female | * |
dc.subject.mesh | Risk Factors | * |
dc.subject.mesh | Cohort Studies | * |
dc.title | Risk of Cause-Specific Death in Individuals With Diabetes: A Competing Risks Analysis | en |
dc.type | research article | en |
dc.rights.license | Attribution-NonCommercial 4.0 International | * |
dc.identifier.pubmedID | 27493134 | es_ES |
dc.format.volume | 39 | es_ES |
dc.format.number | 11 | es_ES |
dc.format.page | 1987-1995 | es_ES |
dc.identifier.doi | 10.2337/dc16-0614 | |
dc.identifier.e-issn | 1935-5548 | es_ES |
dc.relation.publisherversion | https://dx.doi.org/10.2337/dc16-0614 | en |
dc.identifier.journal | Diabetes Care | es_ES |
dc.rights.accessRights | open access | en |
dc.subject.decs | Estudios de Cohortes | * |
dc.subject.decs | Femenino | * |
dc.subject.decs | Análisis Multivariante | * |
dc.subject.decs | Masculino | * |
dc.subject.decs | Estudios de Seguimiento | * |
dc.subject.decs | Factores de Riesgo | * |
dc.subject.decs | Humanos | * |
dc.subject.decs | Esperanza de Vida | * |
dc.subject.decs | Persona de Mediana Edad | * |
dc.subject.decs | Neoplasias | * |
dc.subject.decs | Glucemia | * |
dc.subject.decs | Causas de Muerte | * |
dc.subject.decs | Anciano | * |
dc.subject.decs | Medición de Riesgo | * |
dc.subject.decs | Diabetes Mellitus Tipo 2 | * |
dc.subject.decs | Enfermedades Cardiovasculares | * |
dc.subject.decs | Diabetes Mellitus Tipo 1 | * |
dc.subject.decs | Adulto | * |
dc.identifier.scopus | 2-s2.0-84994300380 | |
dc.identifier.wos | 386328800030 | |
dc.identifier.pui | L613125679 | |