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dc.contributor.author | García-Cosío, Borja | |
dc.contributor.author | Soriano, Joan B | |
dc.contributor.author | Lopez-Campos, Jose Luis | |
dc.contributor.author | Calle, Myriam | |
dc.contributor.author | Soler, Juan Jose | |
dc.contributor.author | de-Torres, Juan Pablo | |
dc.contributor.author | Marin, Jose María | |
dc.contributor.author | Martinez, Cristina | |
dc.contributor.author | de Lucas, Pilar | |
dc.contributor.author | Mir, Isabel | |
dc.contributor.author | Peces-Barba, German | |
dc.contributor.author | Feu-Collado, Nuria | |
dc.contributor.author | Solanes-Garcia, Ingrid | |
dc.contributor.author | Alfageme, Inmaculada | |
dc.contributor.author | CHAIN Study | |
dc.date.accessioned | 2024-07-09T09:14:18Z | |
dc.date.available | 2024-07-09T09:14:18Z | |
dc.date.issued | 2016-09-29 | |
dc.identifier.citation | Cosio BG, Soriano JB, Lopez-Campos JL, Calle M, Soler JJ, De-Torres JP, et al. Distributionand Outcomes of a Phenotype-Based Approach to Guide COPD Management: Results from the CHAIN Cohort. PLoS One. 2016 Sep 29;11(9):e0160770. | en |
dc.identifier.issn | 1932-6203 | |
dc.identifier.other | http://hdl.handle.net/20.500.13003/10192 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/20288 | |
dc.description.abstract | Rationale The Spanish guideline for COPD (GesEPOC) recommends COPD treatment according to four clinical phenotypes: non-exacerbator phenotype with either chronic bronchitis or emphysema (NE), asthma-COPD overlap syndrome (ACOS), frequent exacerbator phenotype with emphysema (FEE) or frequent exacerbator phenotype with chronic bronchitis (FECB). However, little is known on the distribution and outcomes of the four suggested phenotypes. Objective We aimed to determine the distribution of these COPD phenotypes, and their relation with one-year clinical outcomes. Methods We followed a cohort of well-characterized patients with COPD up to one-year. Baseline characteristics, health status (CAT), BODE index, rate of exacerbations and mortality up to one year of follow-up were compared between the four phenotypes. Results Overall, 831 stable COPD patients were evaluated. They were distributed as NE, 550 (66.2%); ACOS, 125 (15.0%); FEE, 38 (4.6%); and FECB, 99 (11.9%); additionally 19 (2.3%) COPD patients with frequent exacerbations did not fulfill the criteria for neither FEE nor FECB. At baseline, there were significant differences in symptoms, FEV1 and BODE index (all p<0.05). The FECB phenotype had the highest CAT score (17.1 +/- 8.2, p<0.05 compared to the other phenotypes). Frequent exacerbator groups (FEE and FECB) were receiving more pharmacological treatment at baseline, and also experienced more exacerbations the year after (all p<0.05) with no differences in one-year mortality. Most of NE (93%) and half of exacerbators were stable after one year. Conclusions There is an uneven distribution of COPD phenotypes in stable COPD patients, with significant differences in demographics, patient-centered outcomes and health care resources use. | en |
dc.description.sponsorship | The COPD research program of the Spanish Society of Pneumology and Thoracic Surgery (PII de EPOC of SEPAR) endorsed this study. We thank Astra-Zeneca for financial support to perform this study. There was no additional external funding received for this study. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. | es_ES |
dc.language.iso | eng | en |
dc.publisher | Public Library of Science (PLOS) | en |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.title | Distributionand Outcomes of a Phenotype-Based Approach to Guide COPD Management: Results from the CHAIN Cohort | en |
dc.type | research article | en |
dc.rights.license | Attribution 4.0 International | * |
dc.identifier.pubmedID | 27684372 | es_ES |
dc.format.volume | 11 | es_ES |
dc.format.number | 9 | es_ES |
dc.format.page | e0160770 | es_ES |
dc.identifier.doi | 10.1371/journal.pone.0160770 | |
dc.relation.publisherversion | https://dx.doi.org/10.1371/journal.pone.0160770 | en |
dc.identifier.journal | PloS One | es_ES |
dc.rights.accessRights | open access | en |
dc.identifier.scopus | 2-s2.0-84991783834 | |
dc.identifier.wos | 384328500006 | |
dc.identifier.pui | L612795514 |
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