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dc.contributor.author | Lopez-Andrade, Bernardo | |
dc.contributor.author | Gutierrez, Antonio | |
dc.contributor.author | Garcia, Lucia | |
dc.contributor.author | Cunill, Vanesa | |
dc.contributor.author | Duran Pastor, Maria Antonia | |
dc.contributor.author | Sampol Mayol, Antonia | |
dc.contributor.author | Bernues, Marta | |
dc.contributor.author | Iglesias, Julio | |
dc.contributor.author | Ramos-Asensio, Rafael | |
dc.contributor.author | Llado, Josep | |
dc.contributor.author | Sanchez, Maria | |
dc.contributor.author | Carlos Amat, Juan | |
dc.contributor.author | Martinez-Serra, Jordi | |
dc.date.accessioned | 2024-07-09T09:14:13Z | |
dc.date.available | 2024-07-09T09:14:13Z | |
dc.date.issued | 2016-07-29 | |
dc.identifier.citation | Lopez-Andrade B, Sartori F, Gutierrez A, Garcia L, Cunill Monjo V, Duran Pastor MA, et al. Acute lymphoblastic leukemia with e1a3 BCR/ABL fusion protein. A report of two cases. Exp Hematol Oncol. 2016 Jul 29;5:21. | en |
dc.identifier.other | http://hdl.handle.net/20.500.13003/10270 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/20279 | |
dc.description.abstract | B Acute Lymphoblastic leukemia (B-ALL) with Philadelphia chromosome (Ph') is a neoplasm of lymphoblast committed to the B cell lineage. The clinical presentation of B-ALL Ph'+ is similar to B-ALL, but is more common in adults than in children. The e1a3 rare variant is produced by the fusion of BCR exon 1 to ABL exon 3. The presence of this translocation has been associated with good disease outcome for chronic myeloid leukemia in a very small series of only 5 cases; there is no such evidence for B-ALL. We report two new cases of B-ALL Ph+ with the rare e1a3 fusion transcript. The e1a3 and e1a2 (p190) transcripts have been reported to have a similar molecular weight and probably a similar clinical profile, thus in these cases the presence of e1a3 was associated with extramedullary infiltration and disease acceleration. | en |
dc.language.iso | eng | en |
dc.publisher | BioMed Central (BMC) | en |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.title | Acute lymphoblastic leukemia with e1a3 BCR/ABL fusion protein. A report of two cases | en |
dc.type | research article | en |
dc.rights.license | Attribution 4.0 International | * |
dc.identifier.pubmedID | 27478684 | es_ES |
dc.format.volume | 5 | es_ES |
dc.format.page | 21 | es_ES |
dc.identifier.doi | 10.1186/s40164-016-0049-y | |
dc.identifier.e-issn | 2162-3619 | es_ES |
dc.relation.publisherversion | https://dx.doi.org/10.1186/s40164-016-0049-y | en |
dc.identifier.journal | Experimental Hematology & Oncology | es_ES |
dc.rights.accessRights | open access | en |
dc.identifier.scopus | 2-s2.0-85006219363 | |
dc.identifier.wos | 381118900001 | |
dc.identifier.pui | L611406479 |
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