Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/20270
Título
Clinical features of suspected Ebola cases referred to the Moyamba ETC, Sierra Leone: challenges in the later stages of the 2014 outbreak
Autor(es)
Arranz Izquierdo, Javier | Lundeby, Karen Marie | Hassan, Shoaib | Zabala Fuentes, Luis Matias | San Jose Garces, Pedro | Haaskjold, Yngvar Lunde | Bolkan, Hakon Angell | Krogh, Kurt Osthuus | Jongopi, James | Mellesmo, Sindre | Josendal, Ola | Opstad, Asmund | Svensen, Erling | Kamara, Alfred Sandy | Roberts, David P | Stamper, Paul D | Austin, Paula | Moosa, Alfredo J | Marke, Dennis | Berg, Ase | Blomberg, Bjorn | Riera, Melchor
Fecha de publicación
2016-06-22
Cita
Arranz J, Lundeby KM, Hassan S, Zabala Fuentes LM, San Jose Garces P, Haaskjold YL, et al. Clinical features of suspected Ebola cases referred to the Moyamba ETC, Sierra Leone: challenges in the later stages of the 2014 outbreak. BMC Infect Dis. 2016 Jun 22;16:308.
Idioma
Inglés
Tipo de documento
research article
Resumen
Background: The last ebola virus disease (EVD) outbreak has been the most important since 1976. EVD cases decreased drastically in Sierra Leone at the beginning of 2015. We aim to determine the clinical findings and evolution of patients admitted to an Ebola treatment center (ETC) during the epidemic's late phase. Methods: We analyze retrospectively data of patients admitted to the Moyamba ETC (December 2014-March 2015). Patients were classified in EVD or non-EVD patients according to the results of Ebola virus real-time reverse transcription polymerase chain reaction (ZAIRE-RT-PCR). Results: Seventy-five patients were included, 41.3 % were positive for ZAIRE-RT-PCR. More women (68 % vs 28 %, p = 0.001) were EVD-positive. More EVD patients had previous contact with an Ebola patient (74.2 % vs 36.3 %, p < 0. 001). At admission, EVD patients were more likely to have fatigue (96.7 %, p < 0.001), diarrhea (67.7 %, p = 0.002), and muscle pain (61.3 %, p = 0.009); but only objective fevers in 35.5 % of EVD patients. The most reliable criteria for diagnosis were: contact with an Ebola patient plus three WHO symptoms (LR+ = 3.7, 95 % CI = 1.9-7.3), and positive contact (LR+ = 2.3, 95 % CI = 1.15-4.20). Only 45.2 % of EVD patients developed fevers during stay, but 75 % developed gastrointestinal symptoms. Non-EVD patients had gastrointestinal problems (33 %), respiratory conditions (26.6 %), and others such as malaria, HIV or tuberculosis with a mortality rate of 11.4 %. vs 58 % in EVD group (p < 0.001). Conclusions: More non-EVD patients were admitted in the outbreak's late phases. The low percentage of initial fever highlights the need to emphasize the epidemiological information. EVD patients presented new symptoms getting worse and requiring closer follow-up. Diagnoses of non-EVD patients were diverse with a remarkable mortality, presenting a challenge for the health system.
Palabras clave
Ebola virus disease (EVD) | Sierra Leone | Clinical features of suspected Ebola patients | Diagnostic validation
MESH
Child | Reverse Transcriptase Polymerase Chain Reaction | Aged, 80 and over | Aged | Young Adult | Adult | Hemorrhagic Fever, Ebola | Sierra Leone | Humans | Real-Time Polymerase Chain Reaction | Fever | HIV Infections | Male | Disease Outbreaks | Female | Respiratory Tract Diseases | Retrospective Studies | Diarrhea | Child, Preschool | Gastrointestinal Diseases | Adolescent | Fatigue | Middle Aged | Infant | Malaria | Epidemics | Hospitalization | Infant, Newborn | Referral and Consultation | Ebolavirus
DECS
Femenino | Lactante | Reacción en Cadena de la Polimerasa de Transcriptasa Inversa | Fatiga | Sierra Leona | Adolescente | Brotes de Enfermedades | Masculino | Preescolar | Reacción en Cadena en Tiempo Real de la Polimerasa | Enfermedades Gastrointestinales | Persona de Mediana Edad | Derivación y Consulta | Diarrea | Epidemias | Fiebre Hemorrágica Ebola | Enfermedades Respiratorias | Recién Nacido | Infecciones por VIH | Malaria | Ebolavirus | Hospitalización | Fiebre | Humanos | Adulto Joven | Anciano | Anciano de 80 o más Años | Niño | Estudios Retrospectivos | Adulto
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