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dc.contributor.author | Bibiloni Esteva, Maria Del Mar | |
dc.contributor.author | Salas, Rogelio | |
dc.contributor.author | Nunez, Georgina M | |
dc.contributor.author | Villarreal, Jesus Z | |
dc.contributor.author | Soldevila Verdeguer, Carla | |
dc.contributor.author | Tur, Josep A | |
dc.date.accessioned | 2024-07-09T09:13:15Z | |
dc.date.available | 2024-07-09T09:13:15Z | |
dc.date.issued | 2016-05-20 | |
dc.identifier.citation | Bibiloni Esteva MM, Salas R, Nunez GM, Villarreal JZ, Sureda Gomila A, Tur J. Relation between Liver Transaminases and Dyslipidaemia among 2-10 y.o. Northern Mexican Children. PLoS One. 2016 May 20;11(5):e0155994. | en |
dc.identifier.issn | 1932-6203 | |
dc.identifier.other | http://hdl.handle.net/20.500.13003/10360 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/20264 | |
dc.description.abstract | Background and Aims: The increase in overweight and obese children may be linked to increased rates of liver damage and dyslipidaemia. This study aimed to explore the associations of liver biomarkers with overweight/obesity and dyslipidaemia in Mexican children. Methods: The study was a population-based cross-sectional nutritional survey carried out in the State of Nuevo Leon, Mexico. The study included a 414 subjects aged between 2 and 10 years old (47.8% girls) who took part in the State Survey of Nutrition and Health-Nuevo Leon 2011/2012. Associations between alanine aminotransferase (ALT) and aspartate aminotransferase (AST), ALT/AST ratio, and major components of serum lipid profile were assessed. Results: Children with high ALT (defined as >= P-75) showed higher prevalence of dyslipidaemia than their counterparts, with high prevalence of high TChol (P = 0.053), non-HDL-chol, TG, and low HDL-chol. Children with an AST/ALT >= T3 ratio were 0.43-times (95% CI: 0.25-0.74) and 0.27-times (95% CI: 0.17-0.44) low likely to be overweight/obese and to have dyslipidaemia than those with an AST/ALT <T1 ratio, respectively. The risk of high TChol, LDL-chol, non-HDL-chol and TG, and low HDL-chol levels also decreased in AST/ALT ratio groups. Conclusions: Our results pose the need for further investigation on whether AST/ALT may be useful as screening test in the assessment of children with cardiometabolic risk. | en |
dc.description.sponsorship | This work was supported by the Department of Health, Government of the State of Nuevo Leon (Mexico), State Survey of Nutrition and Health-Nuevo Leon 2011/2012 (EESN-NL 2011/2012). It was also supported by the Spanish Ministry of Health and Consumer Affairs (Programme for Promotion of Biomedical Research and Health Sciences, Projects 11/01791 and 14/00636, Red Predimed-RETIC RD06/0045/1004, and CIBEROBN CB12/03/30038). Grant of support was given to research groups no. 35/2011 (Balearic Islands Gov.) and EU FEDER funds. This work was also supported by the Research Group on Community Nutrition and Oxidative Stress, University of the Balearic Islands, coming under the Centre Catala de la Nutricio (IEC) and Exernet Network. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. | es_ES |
dc.language.iso | eng | en |
dc.publisher | Public Library of Science (PLOS) | en |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject.mesh | Child | * |
dc.subject.mesh | Aspartate Aminotransferases | * |
dc.subject.mesh | Humans | * |
dc.subject.mesh | Child, Preschool | * |
dc.subject.mesh | Mexico | * |
dc.subject.mesh | Alanine Transaminase | * |
dc.subject.mesh | Cross-Sectional Studies | * |
dc.subject.mesh | Obesity | * |
dc.subject.mesh | Liver | * |
dc.subject.mesh | Biomarkers | * |
dc.subject.mesh | Cholesterol, HDL | * |
dc.subject.mesh | Dyslipidemias | * |
dc.subject.mesh | Overweight | * |
dc.title | Relation between Liver Transaminases and Dyslipidaemia among 2-10 y.o. Northern Mexican Children | en |
dc.type | research article | en |
dc.rights.license | Attribution 4.0 International | * |
dc.identifier.pubmedID | 27203747 | es_ES |
dc.format.volume | 11 | es_ES |
dc.format.number | 5 | es_ES |
dc.format.page | e0155994 | es_ES |
dc.identifier.doi | 10.1371/journal.pone.0155994 | |
dc.relation.publisherversion | https://dx.doi.org/10.1371/journal.pone.0155994 | en |
dc.identifier.journal | PloS One | es_ES |
dc.rights.accessRights | open access | en |
dc.subject.decs | Biomarcadores | * |
dc.subject.decs | HDL-Colesterol | * |
dc.subject.decs | Hígado | * |
dc.subject.decs | Estudios Transversales | * |
dc.subject.decs | Preescolar | * |
dc.subject.decs | Dislipidemias | * |
dc.subject.decs | Humanos | * |
dc.subject.decs | Obesidad | * |
dc.subject.decs | Alanina Transaminasa | * |
dc.subject.decs | México | * |
dc.subject.decs | Niño | * |
dc.subject.decs | Aspartato Aminotransferasas | * |
dc.subject.decs | Sobrepeso | * |
dc.identifier.scopus | 2-s2.0-84991518885 | |
dc.identifier.wos | 376291500038 | |
dc.identifier.pui | L610470876 |
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