dc.contributor.author | Di Lorenzo, Arianna | |
dc.contributor.author | Bloise, Nora | |
dc.contributor.author | Meneghini, Silvia | |
dc.contributor.author | Soldevila Verdeguer, Carla | |
dc.contributor.author | Tenore, Gian Carlo | |
dc.contributor.author | Visai, Livia | |
dc.contributor.author | Arciola, Carla Renata | |
dc.contributor.author | Daglia, Maria | |
dc.date.accessioned | 2024-07-09T09:13:14Z | |
dc.date.available | 2024-07-09T09:13:14Z | |
dc.date.issued | 2016-05 | |
dc.identifier.citation | Di Lorenzo A, Bloise N, Meneghini S, Sureda Gomila A, Tenore G, Visai L, et al. Effect of Winemaking on the Composition of Red Wine as a Source of Polyphenols for Anti-Infective Biomaterials. Materials. 2016 May;9(5):316. | en |
dc.identifier.other | http://hdl.handle.net/20.500.13003/10366 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/20260 | |
dc.description.abstract | Biomaterials releasing bactericides have currently become tools for thwarting medical device-associated infections. The ideal anti-infective biomaterial must counteract infection while safeguarding eukaryotic cell integrity. Red wine is a widely consumed beverage to which many biological properties are ascribed, including protective effects against oral infections and related bone (osteoarthritis, osteomyelitis, periprosthetic joint infections) and cardiovascular diseases. In this study, fifteen red wine samples derived from grapes native to the Oltrepo Pavese region (Italy), obtained from the winemaking processes of Bonarda dell'Oltrepo Pavese red wine, were analyzed alongside three samples obtained from marc pressing. Total polyphenol and monomeric anthocyanin contents were determined and metabolite profiling was conducted by means of a chromatographic analysis. Antibacterial activity of wine samples was evaluated against Streptococcus mutans, responsible for dental caries, Streptococcus salivarius, and Streptococcus pyogenes, two oral bacterial pathogens. Results highlighted the winemaking stages in which samples exhibit the highest content of polyphenols and the greatest antibacterial activity. Considering the global need for new weapons against bacterial infections and alternatives to conventional antibiotics, as well as the favorable bioactivities of polyphenols, results point to red wine as a source of antibacterial substances for developing new anti-infective biomaterials and coatings for biomedical devices. | en |
dc.description.sponsorship | The research leading to these results has received funding from the project entitled Esperienze di Riso e Vino nella terra dei Longobardi e dei Visconti approved by Regione Lombardia (Dds n. 11527-3/12/2014). The authors would like to thank the vineyard I Doria di Montalto (Montalto Pavese, PV) and especially Daniele Manini for providing wine samples and giving us technical support for writing the Materials and Method Section, and Alessandra Leoni for the collection of wine samples. Antoni Sureda was supported by the Spanish Ministry of Health, Social Services and Equality (CIBEROBN-CB12/03/30038). Carla Renata Arciola acknowledges the financial contribution of 5 per mille grants for Health Research to the Rizzoli Orthopedic Institute of Bologna. | es_ES |
dc.language.iso | eng | en |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | en |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Red wine | |
dc.subject | Winemaking process | |
dc.subject | Metabolite profiling | |
dc.subject | Polyphenols | |
dc.subject | Anti-infective biomaterials | |
dc.title | Effect of Winemaking on the Composition of Red Wine as a Source of Polyphenols for Anti-Infective Biomaterials | en |
dc.type | research article | en |
dc.rights.license | Attribution 4.0 International | * |
dc.identifier.pubmedID | 28773444 | es_ES |
dc.format.volume | 9 | es_ES |
dc.format.number | 5 | es_ES |
dc.format.page | 316 | es_ES |
dc.identifier.doi | 10.3390/ma9050316 | |
dc.identifier.e-issn | 1996-1944 | es_ES |
dc.relation.publisherversion | https://dx.doi.org/10.3390/ma9050316 | en |
dc.identifier.journal | Materials | es_ES |
dc.rights.accessRights | open access | en |
dc.identifier.scopus | 2-s2.0-84969920404 | |
dc.identifier.wos | 378628500011 | |