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dc.contributor.author | Busquets-Cortés, Carla | |
dc.contributor.author | Capó Fiol, Xavier | |
dc.contributor.author | Martorell, Miquel | |
dc.contributor.author | Tur, Josep A | |
dc.contributor.author | Soldevila Verdeguer, Carla | |
dc.contributor.author | Pons, Antoni | |
dc.date.accessioned | 2024-07-09T09:13:05Z | |
dc.date.available | 2024-07-09T09:13:05Z | |
dc.date.issued | 2016 | |
dc.identifier.citation | Busquets-Cortes C, Capo Fiol X, Martorell M, Tur J, Sureda Gomila A, Pons A. Training Enhances Immune Cells Mitochondrial Biosynthesis, Fission, Fusion, and Their Antioxidant Capabilities Synergistically with Dietary Docosahexaenoic Supplementation. Oxidative Med Cell Longev. 2016;2016:8950384. | en |
dc.identifier.issn | 1942-0900 | |
dc.identifier.other | http://hdl.handle.net/20.500.13003/10533 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/20242 | |
dc.description.abstract | Exercise training induces adaptations in mitochondrial metabolism, dynamics, and oxidative protection. Omega-3 fatty acids change membrane lipid composition and modulate mitochondrial function. The aim was to investigate the effect of 8-week training and docosahexaenoic acid (DHA) supplementation (1.14 g/day) on the mitochondria dynamics and antioxidant status in peripheral blood mononuclear cells (PBMCs) from sportsmen. Subjects were assigned to an intervention (N = 9) or placebo groups (N = 7) in a randomized double-blind trial. Nutritional intervention significantly increased the DHA content in erythrocyte membranes from the experimental group. No significant differences were reported in terms of circulating PBMCs, Mn-superoxide dismutase protein levels, and their capability to produce reactive oxygen species. The proteins related to mitochondrial dynamics were, in general, increased after an 8-week training and this increase was enhanced by DHA supplementation. The content in mitofusins Mtf-1 and Mtf-2, optic atrophy protein-1 (Opa-1), and mitochondrial transcription factor A (Tfam) were significantly higher in the DHA-supplemented group after intervention. Cytochrome c oxidase (COX-IV) activity and uncoupling proteins UCP-2 and UCP-3 protein levels were increased after training, with higher UCP-3 levels in the supplemented group. In conclusion, training induced mitochondrial adaptations which may contribute to improved mitochondrial function. This mitochondrial response was modulated by DHA supplementation. | en |
dc.description.sponsorship | Thanks are due to Accion Estrategica en Salud del Ministerio de Ciencia e Innovacion DPS2008-07033-C03-03, Programme of Promotion of Biomedical Research and Health Sciences, (Projects PI11/01791 and PI14/00636, Red Predimed-RETIC RD06/0045/1004, CIBEROBN CB12/03/30038) and Balearic Island Government and FEDER funds (35/2011 and 23/2012). The authors hereby acknowledge the PhD grant provided by the University of the Balearic Island and the FPI/1648/2014 grant provided by Conselleria d'Educacio, Cultura i Universitats, Direccio General d'Universitats i Recerca, Govern de les Illes Balears, within the program framework cofinanced by Fondo Social Europeo. | es_ES |
dc.language.iso | eng | en |
dc.publisher | Hindawi | en |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.title | Training Enhances Immune Cells Mitochondrial Biosynthesis, Fission, Fusion, and Their Antioxidant Capabilities Synergistically with Dietary Docosahexaenoic Supplementation | en |
dc.type | research article | en |
dc.rights.license | Attribution 4.0 International | * |
dc.identifier.pubmedID | 27698953 | es_ES |
dc.format.volume | 2016 | es_ES |
dc.format.page | 8950384 | es_ES |
dc.identifier.doi | 10.1155/2016/8950384 | |
dc.identifier.e-issn | 1942-0994 | es_ES |
dc.relation.publisherversion | https://dx.doi.org/10.1155/2016/8950384 | en |
dc.identifier.journal | Oxidative Medicine and Cellular Longevity | es_ES |
dc.rights.accessRights | open access | en |
dc.identifier.scopus | 2-s2.0-84988735580 | |
dc.identifier.wos | 383501600001 | |
dc.identifier.pui | L612301901 |
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