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dc.contributor.author | Sala-Vila, Aleix | |
dc.contributor.author | Guasch-Ferre, Marta | |
dc.contributor.author | Hu, Frank B | |
dc.contributor.author | Sanchez-Tainta, Ana | |
dc.contributor.author | bullo, Monica | |
dc.contributor.author | Serra-Mir, Merce | |
dc.contributor.author | Lopez-Sabater, Carmen | |
dc.contributor.author | Sorli, Jose V | |
dc.contributor.author | Aros, Fernando | |
dc.contributor.author | Fiol Sala, Miquel | |
dc.contributor.author | Munoz, Miguel A | |
dc.contributor.author | Serra-Majem, Luis | |
dc.contributor.author | Alfredo Martinez, J | |
dc.contributor.author | Corella, Dolores | |
dc.contributor.author | Fito, Montserrat | |
dc.contributor.author | Salas-Salvado, Jordi | |
dc.contributor.author | Martinez-Gonzalez, Miguel A | |
dc.contributor.author | Estruch, Ramon | |
dc.contributor.author | Ros, Emilio | |
dc.contributor.author | PREDIMED Investigators | |
dc.date.accessioned | 2024-07-09T09:13:02Z | |
dc.date.available | 2024-07-09T09:13:02Z | |
dc.date.issued | 2016-01 | |
dc.identifier.citation | Sala-Vila A, Guasch-Ferre M, Hu FB, Sanchez-Tainta A, Bullo M, Serra-Mir M, et al. Dietary alpha-Linolenic Acid, Marine omega-3 Fatty Acids, and Mortality in a Population With High Fish Consumption: Findings From the PREvencion con Dleta MEDiterranea (PREDIMED) Study. J Am Heart Assoc. 2016 Jan;5(1):e002543. | en |
dc.identifier.issn | 2047-9980 | |
dc.identifier.other | http://hdl.handle.net/20.500.13003/17184 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/20238 | |
dc.description.abstract | Background-Epidemiological evidence suggests a cardioprotective role of a-linolenic acid (ALA), a plant-derived x-3 fatty acid. It is unclear whether ALA is beneficial in a background of high marine x-3 fatty acids (long-chain n-3 polyunsaturated fatty acids) intake. In persons at high cardiovascular risk from Spain, a country in which fish consumption is customarily high, we investigated whether meeting the International Society for the Study of Fatty Acids and Lipids recommendation for dietary ALA (0.7% of total energy) at baseline was related to all-cause and cardiovascular disease mortality. We also examined the effect of meeting the society's recommendation for long-chain n-3 polyunsaturated fatty acids (>= 500 mg/day). Methods and Results-We longitudinally evaluated 7202 participants in the PREvencion con DIeta MEDiterranea (PREDIMED) trial. Multivariable-adjusted Cox regressionmodels were fitted to estimate hazard ratios. ALA intake correlated towalnut consumption (r= 0.94). During a 5.9-y follow-up, 431 deaths occurred (104 cardiovascular disease, 55 coronary heart disease, 32 sudden cardiac death, 25 stroke). The hazard ratios formeeting ALArecommendation (n= 1615, 22.4%) were 0.72 (95% CI 0.56-0.92) for all-causemortality and 0.95 (95% CI 0.58-1.57) for fatal cardiovascular disease. The hazard ratios formeeting the recommendation for long-chain n-3 polyunsaturated fatty acids (n= 5452, 75.7%) were 0.84 (95% CI 0.67-1.05) for all-causemortality, 0.61 (95% CI 0.39-0.96) for fatal cardiovascular disease, 0.54 (95% CI 0.29-0.99) for fatal coronary heart disease, and 0.49 (95% CI 0.22-1.01) for sudden cardiac death. The highest reduction in all-cause mortality occurred in participants meeting both recommendations (hazard ratio 0.63 [ 95% CI 0.45-0.87]). Conclusions-In participants without prior cardiovascular disease and high fish consumption, dietary ALA, supplied mainly by walnuts and olive oil, relates inversely to all-cause mortality, whereas protection from cardiac mortality is limited to fish-derived long-chain n-3 polyunsaturated fatty acids. | en |
dc.description.sponsorship | This study was funded in part by Instituto de Salud Carlos III (ISCIII) (Spanish Ministry of Economy) through grants RTIC G03/140, RTIC RD 06/0045, Centro Nacional de Investigaciones Cardiovasculares CNIC 06/2007, ISCIII FIS PS09/01292, the Spanish Ministry of Science and Innovation (MICINN) AGL2010-22319-C03-02 and AGL2009-13906-C02-02, and an unrestricted grant from the California Walnut Commission. Sala-Vila holds a Miguel Servet I fellowship from the Ministry of Economy and Competitiveness through the ISCIII. | es_ES |
dc.language.iso | eng | en |
dc.publisher | Wiley | en |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/ | * |
dc.subject | Fatty acid | |
dc.subject | Nutrition | |
dc.subject | Sudden cardiac death | |
dc.subject.mesh | Aged, 80 and over | * |
dc.subject.mesh | Aged | * |
dc.subject.mesh | Risk Assessment | * |
dc.subject.mesh | Humans | * |
dc.subject.mesh | Protective Factors | * |
dc.subject.mesh | Risk Reduction Behavior | * |
dc.subject.mesh | Nuts | * |
dc.subject.mesh | Nutritive Value | * |
dc.subject.mesh | Diet | * |
dc.subject.mesh | Male | * |
dc.subject.mesh | Multivariate Analysis | * |
dc.subject.mesh | Time Factors | * |
dc.subject.mesh | Chi-Square Distribution | * |
dc.subject.mesh | Female | * |
dc.subject.mesh | Risk Factors | * |
dc.subject.mesh | Juglans | * |
dc.subject.mesh | Cardiovascular Diseases | * |
dc.subject.mesh | Spain | * |
dc.subject.mesh | Middle Aged | * |
dc.subject.mesh | Longitudinal Studies | * |
dc.subject.mesh | Fatty Acids, Omega-3 | * |
dc.subject.mesh | Prospective Studies | * |
dc.subject.mesh | Seafood | * |
dc.subject.mesh | Proportional Hazards Models | * |
dc.subject.mesh | Olive Oil | * |
dc.subject.mesh | alpha-Linolenic Acid | * |
dc.title | Dietary alpha-Linolenic Acid, Marine omega-3 Fatty Acids, and Mortality in a Population With High Fish Consumption: Findings From the PREvencion con Dleta MEDiterranea (PREDIMED) Study | en |
dc.type | review article | en |
dc.rights.license | Attribution-NonCommercial 4.0 International | * |
dc.identifier.pubmedID | 26813890 | es_ES |
dc.format.volume | 5 | es_ES |
dc.format.number | 1 | es_ES |
dc.format.page | e002543 | es_ES |
dc.identifier.doi | 10.1161/JAHA.115.002543 | |
dc.relation.publisherversion | https://dx.doi.org/10.1161/JAHA.115.002543 | en |
dc.identifier.journal | Journal of the American Heart Association | es_ES |
dc.rights.accessRights | open access | en |
dc.subject.decs | Ácido alfa-Linolénico | * |
dc.subject.decs | Modelos de Riesgos Proporcionales | * |
dc.subject.decs | Alimentos Marinos | * |
dc.subject.decs | Ácidos Grasos Omega-3 | * |
dc.subject.decs | Femenino | * |
dc.subject.decs | Dieta | * |
dc.subject.decs | Conducta de Reducción del Riesgo | * |
dc.subject.decs | Masculino | * |
dc.subject.decs | Factores Protectores | * |
dc.subject.decs | Estudios Longitudinales | * |
dc.subject.decs | Persona de Mediana Edad | * |
dc.subject.decs | Estudios Prospectivos | * |
dc.subject.decs | Medición de Riesgo | * |
dc.subject.decs | Enfermedades Cardiovasculares | * |
dc.subject.decs | Distribución de Chi-Cuadrado | * |
dc.subject.decs | Factores de Tiempo | * |
dc.subject.decs | Análisis Multivariante | * |
dc.subject.decs | Valor Nutritivo | * |
dc.subject.decs | Aceite de Oliva | * |
dc.subject.decs | Juglans | * |
dc.subject.decs | Factores de Riesgo | * |
dc.subject.decs | Humanos | * |
dc.subject.decs | Nueces | * |
dc.subject.decs | Anciano | * |
dc.subject.decs | Anciano de 80 o más Años | * |
dc.subject.decs | España | * |
dc.identifier.scopus | 2-s2.0-84998579388 | |
dc.identifier.wos | 371282800036 | |
dc.identifier.pui | L613254300 |
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