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dc.contributor.author | Aparicio, Javier | |
dc.contributor.author | Carreno, Mar | |
dc.contributor.author | Bargallo, Nuria | |
dc.contributor.author | Setoain, Xavier | |
dc.contributor.author | Rubi, Sebastia | |
dc.contributor.author | Rumia, Jordi | |
dc.contributor.author | Falcon, Carles | |
dc.contributor.author | Calvo, Anna | |
dc.contributor.author | Marti-Fuster, Berta | |
dc.contributor.author | Padilla, Nelly | |
dc.contributor.author | Boget, Teresa | |
dc.contributor.author | Pintor, Luis | |
dc.contributor.author | Donaire, Antonio | |
dc.date.accessioned | 2024-07-09T09:12:50Z | |
dc.date.available | 2024-07-09T09:12:50Z | |
dc.date.issued | 2016 | |
dc.identifier.citation | Aparicio J, Carreno M, Bargallo N, Setoain X, Rubí S, Rumia J, et al. Combined F-18-FDG-PET and diffusion tensor imaging in mesial temporal lobe epilepsy with hippocampal sclerosis. NeuroImage-Clin. 2016;12:976-89. | en |
dc.identifier.issn | 2213-1582 | |
dc.identifier.other | http://hdl.handle.net/20.500.13003/17307 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/20218 | |
dc.description.abstract | Objectives: Several studies using F-18-fluorodeoxyglucose positron emission tomography (F-18-FDG-PET) or diffusion tensor imaging (DTI) have found both temporal and extratemporal abnormalities in patients with mesial temporal lobe epilepsy with ipsilateral hippocampal sclerosis (MTLE-HS), but data are lacking about the findings of both techniques in the same patients. We aimed to determine whether the extent of F-18-FDG-PET hypometabolism is related to DTI abnormalities. Methods: Twenty-one patients with MTLE-HS underwent comprehensive preoperative evaluation; 18 (86%) of these underwent epilepsy surgery. We analyzed and compared the pattern of white matter (WM) alterations on DTI and cortical hypometabolism on F-18-FDG-PET. Results: We found widespread temporal and extratemporal F-18-FDG-PET and DTI abnormalities. Patterns of WM abnormalities and cortical glucose hypometabolism involved similar brain regions, being more extensive in the left than the right MTLE-HS. We classified patients into three groups according to temporal F-18-FDG-PET patterns: hypometabolism restricted to the anterior third (n = 7), hypometabolism extending to the middle third (n = 7), and hypometabolism extending to the posterior third (n = 7). Patients with anterior temporal hypometabolism showed DTI abnormalities in anterior association and commissural tracts while patients with posterior hypometabolism showed WM alterations in anterior and posterior tracts. Conclusions: Patients with MTLE-HS have widespread metabolic and microstructural abnormalities that involve similar regions. The distribution patterns of these gray and white matter abnormalities differ between patients with left or right MTLE, but also with the extent of the F-18-FDG-PET hypometabolism along the epileptogenic temporal lobe. These findings suggest a variable network involvement among patients with MTLE-HS. | en |
dc.description.sponsorship | Funding was provided by grants from the Spanish Fondo de Investigaciones Sanitarias (ISCIII-MICINN), and the European Regional Development Fund (FIS-PI13/00649; PI0890278; FIS-PI080122; FIS-PI060077).; B. Marti-Fuster was awarded a PhD fellowship (App Form-Call 07-2009) from the Institute for Bioengineering of Catalonia (IBEC). | es_ES |
dc.language.iso | eng | en |
dc.publisher | Elsevier | en |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Positron emission tomography | |
dc.subject | DTI | |
dc.subject | MTLE | |
dc.subject | Hippocampus | |
dc.subject | Nerve net | |
dc.subject.mesh | Positron-Emission Tomography | * |
dc.subject.mesh | Young Adult | * |
dc.subject.mesh | Epilepsy, Temporal Lobe | * |
dc.subject.mesh | Adult | * |
dc.subject.mesh | Hippocampus | * |
dc.subject.mesh | White Matter | * |
dc.subject.mesh | Gray Matter | * |
dc.subject.mesh | Humans | * |
dc.subject.mesh | Adolescent | * |
dc.subject.mesh | Middle Aged | * |
dc.subject.mesh | Multimodal Imaging | * |
dc.subject.mesh | Male | * |
dc.subject.mesh | Female | * |
dc.subject.mesh | Diffusion Tensor Imaging | * |
dc.subject.mesh | Sclerosis | * |
dc.subject.mesh | Fluorodeoxyglucose F18 | * |
dc.title | Combined F-18-FDG-PET and diffusion tensor imaging in mesial temporal lobe epilepsy with hippocampal sclerosis | en |
dc.type | research article | en |
dc.rights.license | Attribution-NonCommercial-NoDerivatives 4.0 International | * |
dc.identifier.pubmedID | 27995064 | es_ES |
dc.format.volume | 12 | es_ES |
dc.format.page | 976-989 | es_ES |
dc.identifier.doi | 10.1016/j.nicl.2016.05.002 | |
dc.relation.publisherversion | https://dx.doi.org/10.1016/j.nicl.2016.05.002 | en |
dc.identifier.journal | Neuroimage-Clinical | es_ES |
dc.rights.accessRights | open access | en |
dc.subject.decs | Fluorodesoxiglucosa F18 | * |
dc.subject.decs | Sustancia Blanca | * |
dc.subject.decs | Sustancia Gris | * |
dc.subject.decs | Femenino | * |
dc.subject.decs | Adolescente | * |
dc.subject.decs | Masculino | * |
dc.subject.decs | Tomografía de Emisión de Positrones | * |
dc.subject.decs | Epilepsia del Lóbulo Temporal | * |
dc.subject.decs | Humanos | * |
dc.subject.decs | Persona de Mediana Edad | * |
dc.subject.decs | Hipocampo | * |
dc.subject.decs | Adulto Joven | * |
dc.subject.decs | Imagen Multimodal | * |
dc.subject.decs | Esclerosis | * |
dc.subject.decs | Adulto | * |
dc.subject.decs | Imagen de Difusión Tensora | * |
dc.identifier.scopus | 2-s2.0-84971631217 | |
dc.identifier.wos | 390196400111 | |
dc.identifier.pui | L610626086 |
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