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dc.contributor.authorAparicio, Javier
dc.contributor.authorCarreno, Mar
dc.contributor.authorBargallo, Nuria
dc.contributor.authorSetoain, Xavier
dc.contributor.authorRubi, Sebastia
dc.contributor.authorRumia, Jordi
dc.contributor.authorFalcon, Carles
dc.contributor.authorCalvo, Anna
dc.contributor.authorMarti-Fuster, Berta
dc.contributor.authorPadilla, Nelly
dc.contributor.authorBoget, Teresa
dc.contributor.authorPintor, Luis
dc.contributor.authorDonaire, Antonio
dc.date.accessioned2024-07-09T09:12:50Z
dc.date.available2024-07-09T09:12:50Z
dc.date.issued2016
dc.identifier.citationAparicio J, Carreno M, Bargallo N, Setoain X, Rubí S, Rumia J, et al. Combined F-18-FDG-PET and diffusion tensor imaging in mesial temporal lobe epilepsy with hippocampal sclerosis. NeuroImage-Clin. 2016;12:976-89.en
dc.identifier.issn2213-1582
dc.identifier.otherhttp://hdl.handle.net/20.500.13003/17307
dc.identifier.urihttp://hdl.handle.net/20.500.12105/20218
dc.description.abstractObjectives: Several studies using F-18-fluorodeoxyglucose positron emission tomography (F-18-FDG-PET) or diffusion tensor imaging (DTI) have found both temporal and extratemporal abnormalities in patients with mesial temporal lobe epilepsy with ipsilateral hippocampal sclerosis (MTLE-HS), but data are lacking about the findings of both techniques in the same patients. We aimed to determine whether the extent of F-18-FDG-PET hypometabolism is related to DTI abnormalities. Methods: Twenty-one patients with MTLE-HS underwent comprehensive preoperative evaluation; 18 (86%) of these underwent epilepsy surgery. We analyzed and compared the pattern of white matter (WM) alterations on DTI and cortical hypometabolism on F-18-FDG-PET. Results: We found widespread temporal and extratemporal F-18-FDG-PET and DTI abnormalities. Patterns of WM abnormalities and cortical glucose hypometabolism involved similar brain regions, being more extensive in the left than the right MTLE-HS. We classified patients into three groups according to temporal F-18-FDG-PET patterns: hypometabolism restricted to the anterior third (n = 7), hypometabolism extending to the middle third (n = 7), and hypometabolism extending to the posterior third (n = 7). Patients with anterior temporal hypometabolism showed DTI abnormalities in anterior association and commissural tracts while patients with posterior hypometabolism showed WM alterations in anterior and posterior tracts. Conclusions: Patients with MTLE-HS have widespread metabolic and microstructural abnormalities that involve similar regions. The distribution patterns of these gray and white matter abnormalities differ between patients with left or right MTLE, but also with the extent of the F-18-FDG-PET hypometabolism along the epileptogenic temporal lobe. These findings suggest a variable network involvement among patients with MTLE-HS.en
dc.description.sponsorshipFunding was provided by grants from the Spanish Fondo de Investigaciones Sanitarias (ISCIII-MICINN), and the European Regional Development Fund (FIS-PI13/00649; PI0890278; FIS-PI080122; FIS-PI060077).; B. Marti-Fuster was awarded a PhD fellowship (App Form-Call 07-2009) from the Institute for Bioengineering of Catalonia (IBEC).es_ES
dc.language.isoengen
dc.publisherElsevier en
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectPositron emission tomography
dc.subjectDTI
dc.subjectMTLE
dc.subjectHippocampus
dc.subjectNerve net
dc.subject.meshPositron-Emission Tomography *
dc.subject.meshYoung Adult *
dc.subject.meshEpilepsy, Temporal Lobe *
dc.subject.meshAdult *
dc.subject.meshHippocampus *
dc.subject.meshWhite Matter *
dc.subject.meshGray Matter *
dc.subject.meshHumans *
dc.subject.meshAdolescent *
dc.subject.meshMiddle Aged *
dc.subject.meshMultimodal Imaging *
dc.subject.meshMale *
dc.subject.meshFemale *
dc.subject.meshDiffusion Tensor Imaging *
dc.subject.meshSclerosis *
dc.subject.meshFluorodeoxyglucose F18 *
dc.titleCombined F-18-FDG-PET and diffusion tensor imaging in mesial temporal lobe epilepsy with hippocampal sclerosisen
dc.typeresearch articleen
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.identifier.pubmedID27995064es_ES
dc.format.volume12es_ES
dc.format.page976-989es_ES
dc.identifier.doi10.1016/j.nicl.2016.05.002
dc.relation.publisherversionhttps://dx.doi.org/10.1016/j.nicl.2016.05.002en
dc.identifier.journalNeuroimage-Clinicales_ES
dc.rights.accessRightsopen accessen
dc.subject.decsFluorodesoxiglucosa F18*
dc.subject.decsSustancia Blanca*
dc.subject.decsSustancia Gris*
dc.subject.decsFemenino*
dc.subject.decsAdolescente*
dc.subject.decsMasculino*
dc.subject.decsTomografía de Emisión de Positrones*
dc.subject.decsEpilepsia del Lóbulo Temporal*
dc.subject.decsHumanos*
dc.subject.decsPersona de Mediana Edad*
dc.subject.decsHipocampo*
dc.subject.decsAdulto Joven*
dc.subject.decsImagen Multimodal*
dc.subject.decsEsclerosis*
dc.subject.decsAdulto*
dc.subject.decsImagen de Difusión Tensora*
dc.identifier.scopus2-s2.0-84971631217
dc.identifier.wos390196400111
dc.identifier.puiL610626086


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Attribution-NonCommercial-NoDerivatives 4.0 International
Este Item está sujeto a una licencia Creative Commons: Attribution-NonCommercial-NoDerivatives 4.0 International