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dc.contributor.author | Mijimolle, Nieves | |
dc.contributor.author | Velasco, Juan | |
dc.contributor.author | Dubus, Pierre | |
dc.contributor.author | Guerra, Carmen | |
dc.contributor.author | Weinbaum, Carolyn A | |
dc.contributor.author | Casey, Patrick J | |
dc.contributor.author | Campuzano, Victoria | |
dc.contributor.author | Barbacid, Mariano | |
dc.date.accessioned | 2024-07-08T10:23:29Z | |
dc.date.available | 2024-07-08T10:23:29Z | |
dc.date.issued | 2005-04 | |
dc.identifier.citation | Cancer Cell . 2005;7(4):313-24. | es_ES |
dc.identifier.issn | 1535-6108 | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/20195 | |
dc.description.abstract | Protein farnesyltransferase (FTase) is an enzyme responsible for posttranslational modification of proteins carrying a carboxy-terminal CaaX motif. Farnesylation allows substrates to interact with membranes and protein targets. Using gene-targeted mice, we report that FTase is essential for embryonic development, but dispensable for adult homeostasis. Six-month-old FTase-deficient mice display delayed wound healing and maturation defects in erythroid cells. Embryonic fibroblasts lacking FTase have a flat morphology and reduced motility and proliferation rates. Ablation of FTase in two ras oncogene-dependent tumor models has no significant consequences for tumor initiation. However, elimination of FTase during tumor progression had a limited but significant inhibitory effect. These results should help to better understand the role of protein farnesylation in normal tissues and in tumor development. | es_ES |
dc.description.sponsorship | V Framework Programme of the European Union (QLK3-1999-00875), (SAF2001-0058) Hancock, J.F., Magee, A.I., Childs, J.E., and Marshall, C.J. (1989). All Ras0109) to J.V. P.D. was supported by the Association pour la Recherche proteins are polyisoprenylated but only some are palmitoylated. Cell 57,contre le Cancer (ARC). P.J.C. was supported by NIH grant GM46372. N.M. 1167–1177.was supported by a BEFI Fellowship from the Fondo de Investigación Sanitaria. The CNIO is partially supported by the RTICCC (Red de Centros de Higgins, G.M., and Anderson, R.M. (1931). Restoration of the liver of the Cáncer; FIS C03/10) | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Cell Press | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject.mesh | Alkyl and Aryl Transferases | es_ES |
dc.subject.mesh | Animals | es_ES |
dc.subject.mesh | Cell Proliferation | es_ES |
dc.subject.mesh | Embryo Loss | es_ES |
dc.subject.mesh | Embryo, Mammalian | es_ES |
dc.subject.mesh | Embryonic Development | es_ES |
dc.subject.mesh | Erythroid Cells | es_ES |
dc.subject.mesh | Estrogen Antagonists | es_ES |
dc.subject.mesh | Fibroblasts | es_ES |
dc.subject.mesh | Gene Expression | es_ES |
dc.subject.mesh | Homeostasis | es_ES |
dc.subject.mesh | Integrases | es_ES |
dc.subject.mesh | Liver | es_ES |
dc.subject.mesh | Lung | es_ES |
dc.subject.mesh | Mice | es_ES |
dc.subject.mesh | Mice, Knockout | es_ES |
dc.subject.mesh | Mutation | es_ES |
dc.subject.mesh | Neoplasms | es_ES |
dc.subject.mesh | Skin Neoplasms | es_ES |
dc.subject.mesh | Spleen | es_ES |
dc.subject.mesh | Tamoxifen | es_ES |
dc.subject.mesh | Wound Healing | es_ES |
dc.subject.mesh | ras Proteins | es_ES |
dc.title | Protein farnesyltransferase in embryogenesis, adult homeostasis, and tumor development. | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.identifier.pubmedID | 15837621 | es_ES |
dc.format.volume | 7 | es_ES |
dc.format.number | 4 | es_ES |
dc.format.page | 313 | es_ES |
dc.identifier.doi | 10.1016/j.ccr.2005.03.004 | es_ES |
dc.contributor.funder | United States Department of Health and Human Services | es_ES |
dc.description.peerreviewed | Sí | es_ES |
dc.relation.publisherversion | https://doi.org/10.1016/j.ccr.2005.03.004 | es_ES |
dc.identifier.journal | Cancer cell | es_ES |
dc.repisalud.institucion | CNIO | es_ES |
dc.repisalud.orgCNIO | CNIO::Grupos de investigación::Grupo de Oncología Experimental | es_ES |
dc.rights.accessRights | open access | es_ES |
dc.relation.projectFIS | info:eu-repo/grantAgreement/ES/SAF2001-005 | es_ES |