Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/20195
Título
Protein farnesyltransferase in embryogenesis, adult homeostasis, and tumor development.
Autor(es)
Fecha de publicación
2005-04
Cita
Cancer Cell . 2005;7(4):313-24.
Idioma
Inglés
Tipo de documento
journal article
Resumen
Protein farnesyltransferase (FTase) is an enzyme responsible for posttranslational modification of proteins carrying a carboxy-terminal CaaX motif. Farnesylation allows substrates to interact with membranes and protein targets. Using gene-targeted mice, we report that FTase is essential for embryonic development, but dispensable for adult homeostasis. Six-month-old FTase-deficient mice display delayed wound healing and maturation defects in erythroid cells. Embryonic fibroblasts lacking FTase have a flat morphology and reduced motility and proliferation rates. Ablation of FTase in two ras oncogene-dependent tumor models has no significant consequences for tumor initiation. However, elimination of FTase during tumor progression had a limited but significant inhibitory effect. These results should help to better understand the role of protein farnesylation in normal tissues and in tumor development.
MESH
Alkyl and Aryl Transferases | Animals | Cell Proliferation | Embryo Loss | Embryo, Mammalian | Embryonic Development | Erythroid Cells | Estrogen Antagonists | Fibroblasts | Gene Expression | Homeostasis | Integrases | Liver | Lung | Mice | Mice, Knockout | Mutation | Neoplasms | Skin Neoplasms | Spleen | Tamoxifen | Wound Healing | ras Proteins
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