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dc.contributor.author | Martinez-Gonzalez, Miguel A | |
dc.contributor.author | Salas-Salvado, Jordi | |
dc.contributor.author | Estruch, Ramon | |
dc.contributor.author | Corella, Dolores | |
dc.contributor.author | Fito, Montserrat | |
dc.contributor.author | Ros, Emilio | |
dc.contributor.author | PREDIMED INVESTIGATORS | |
dc.date.accessioned | 2024-07-04T12:56:41Z | |
dc.date.available | 2024-07-04T12:56:41Z | |
dc.date.issued | 2015-07 | |
dc.identifier.citation | Martinez-Gonzalez Miguel A., Salas-Salvado Jordi, Estruch Ramon, Corella Dolores, Fito Montse, Ros Emilio, et al. Benefits of the Mediterranean Diet: Insights From the PREDIMED Study. Prog Cardiovasc Dis. 2015 Jul;58(1):50-60. Epub 2015 May 1. | en |
dc.identifier.issn | 0033-0620 | |
dc.identifier.other | http://hdl.handle.net/20.500.13003/10805 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/20178 | |
dc.description.abstract | The PREDIMED (PREvenciOn con DIeta MEDiterranea) multicenter, randomized, primary prevention trial assessed the long-term effects of the Mediterranean diet (MeDiet) on clinical events of cardiovascular disease (CVD). We randomized 7447 men and women at high CVD risk into three diets: MeDiet supplemented with extra-virgin olive oil (EVOO), MeDiet supplemented with nuts, and control diet (advice on a low-fat diet). No energy restriction and no special intervention on physical activity were applied. We observed 288 CVD events (a composite of myocardial infarction, stroke or CVD death) during a median time of 4.8 years; hazard ratios were 0.70 (95% CI, 0.53-0.91) for the MeDiet + EVOO and 0.70 (CI, 0.53-0.94) for the MeDiet + nuts compared to the control group. Respective hazard ratios for incident diabetes (273 cases) among 3541 non-diabetic participants were 0.60 (0.43-0.85) and 0.82 (0.61-1.10) for MeDiet + EVOO and MeDiet + nuts, respectively versus control. Significant improvements in classical and emerging CVD risk factors also supported a favorable effect of both MeDiets on blood pressure, insulin sensitivity, lipid profiles, lipoprotein particles, inflammation, oxidative stress, and carotid atherosclerosis. In nutrigenomic studies beneficial effects of the intervention with MedDiets showed interactions with several genetic variants (TCF7L2, APOA2, MLXIPL, LPL, FTO, M4CR, COX-2, GCKR and SERPINE1) with respect to intermediate and final phenotypes. Thus, the PREDIMED trial provided strong evidence that a vegetable-based MeDiet rich in unsaturated fat and polyphenols can be a sustainable and ideal model for CVD prevention. | en |
dc.description.sponsorship | Funding disclosure: Supported by the official funding agency for biomedical research of the Spanish government, Instituto de Salud Carlos III (ISCIII), through grants provided to research networks specifically developed for the trial (RTIC G03/140, to Dr. Estruch; RTIC RD 06/0045, to Dr. Martinez-Gonzalez) and through Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y Nutricion (CIBERobn), and by grants from Centro Nacional de Investigaciones Cardiovasculares (CNIC 06/2007), Fondo de Investigacion Sanitaria-Fondo Europe de Desarrollo Regional (PI04-2239, PI 05/2584, CP06/00100, PI07/0240, PI07/1138, PI07/0954, PI 07/0473, PI10/01407, PI10/02658, PI11/01647, P11/02505 and PI13/01090), Ministerio de Ciencia e Innovacion (AGL-2009-13906-C02 and AGL2010-22319-C03), Fundacion Mapfre 2010, Consejeria de Salud de la Junta de Andalucia (PI0105/2007), Public Health Division of the Department of Health of the Autonomous Government of Catalonia, Generalitat Valenciana (ACOMP06109, GVACOMP2010-181, GVACOMP2011-151, ACOMP/2013/165, ACOMP/2013/159, CS2010-AP-111, and CS2011-AP-042), and Regional Government of Navarra (P27/2011). | es_ES |
dc.language.iso | eng | en |
dc.publisher | Elsevier | en |
dc.type.hasVersion | SMUR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Mediterranean diet | en |
dc.subject | Dietary intervention | en |
dc.subject | Randomized trials | en |
dc.subject | Primary prevention | en |
dc.subject | Atrial fibrillation | en |
dc.subject | Peripheral artery disease | en |
dc.subject | Stroke | en |
dc.subject | Type-2 diabetes | en |
dc.subject.mesh | Cardiovascular Diseases | * |
dc.subject.mesh | Genetic Predisposition to Disease | * |
dc.subject.mesh | Randomized Controlled Trials as Topic | * |
dc.subject.mesh | Risk Assessment | * |
dc.subject.mesh | Humans | * |
dc.subject.mesh | Health Status | * |
dc.subject.mesh | Protective Factors | * |
dc.subject.mesh | Risk Reduction Behavior | * |
dc.subject.mesh | Stroke | * |
dc.subject.mesh | Myocardial Infarction | * |
dc.subject.mesh | Prognosis | * |
dc.subject.mesh | Phenotype | * |
dc.subject.mesh | Time Factors | * |
dc.subject.mesh | Risk Factors | * |
dc.subject.mesh | Evidence-Based Medicine | * |
dc.subject.mesh | Diet, Mediterranean | * |
dc.subject.mesh | Gene-Environment Interaction | * |
dc.subject.mesh | Primary Prevention | * |
dc.title | Benefits of the Mediterranean Diet: Insights From the PREDIMED Study | en |
dc.type | review article | en |
dc.rights.license | Attribution-NonCommercial-NoDerivatives 4.0 International | * |
dc.identifier.pubmedID | 25940230 | es_ES |
dc.format.volume | 58 | es_ES |
dc.format.number | 1 | es_ES |
dc.format.page | 50-60 | es_ES |
dc.identifier.doi | 10.1016/j.pcad.2015.04.003 | |
dc.identifier.e-issn | 1873-1740 | es_ES |
dc.relation.publisherversion | https://dx.doi.org/10.1016/j.pcad.2015.04.003 | en |
dc.identifier.journal | Progress in Cardiovascular Diseases | es_ES |
dc.rights.accessRights | open access | en |
dc.subject.decs | Dieta Mediterránea | * |
dc.subject.decs | Accidente Cerebrovascular | * |
dc.subject.decs | Medicina Basada en la Evidencia | * |
dc.subject.decs | Predisposición Genética a la Enfermedad | * |
dc.subject.decs | Factores de Tiempo | * |
dc.subject.decs | Infarto del Miocardio | * |
dc.subject.decs | Conducta de Reducción del Riesgo | * |
dc.subject.decs | Factores Protectores | * |
dc.subject.decs | Interacción Gen-Ambiente | * |
dc.subject.decs | Factores de Riesgo | * |
dc.subject.decs | Humanos | * |
dc.subject.decs | Estado de Salud | * |
dc.subject.decs | Pronóstico | * |
dc.subject.decs | Fenotipo | * |
dc.subject.decs | Medición de Riesgo | * |
dc.subject.decs | Prevención Primaria | * |
dc.subject.decs | Enfermedades Cardiovasculares | * |
dc.subject.decs | Ensayos Clínicos Controlados Aleatorios como Asunto | * |
dc.identifier.scopus | 2-s2.0-84936938968 | |
dc.identifier.wos | 357767000007 | |
dc.identifier.pui | L605274182 |
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