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dc.contributor.author | Tourniaire, Franck | |
dc.contributor.author | Musinovic, Hana | |
dc.contributor.author | Gouranton, Erwan | |
dc.contributor.author | Astier, Julien | |
dc.contributor.author | Marcotorchino, Julie | |
dc.contributor.author | Arreguin, Andrea | |
dc.contributor.author | Bernot, Denis | |
dc.contributor.author | Palou, Andreu | |
dc.contributor.author | Bonet, M Luisa | |
dc.contributor.author | Ribot, Joan | |
dc.contributor.author | Landrier, Jean-Francois | |
dc.date.accessioned | 2024-07-04T12:56:39Z | |
dc.date.available | 2024-07-04T12:56:39Z | |
dc.date.issued | 2015-06 | |
dc.identifier.citation | Tourniaire F, Musinovic H, Gouranton E, Astier J, Marcotorchino J, Arreguin A, et al. All-trans retinoic acid induces oxidative phosphorylation and mitochondria biogenesis in adipocytes. J Lipid Res. 2015 Jun;56(6):1100-9. Epub 2015 Apr 25. | en |
dc.identifier.issn | 0022-2275 | |
dc.identifier.other | http://hdl.handle.net/20.500.13003/10828 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/20173 | |
dc.description.abstract | A positive effect of all-trans retinoic acid (ATRA) on white adipose tissue (WAT) oxidative and thermogenic capacity has been described and linked to an in vivo fat-lowering effect of ATRA in mice. However, little is known about the effects of ATRA on mitochondria in white fat. Our objective has been to characterize the effect of ATRA on mitochondria biogenesis and oxidative phosphorylation (OXPHOS) capacity in mature white adipocytes. Transcriptome analysis, oxygraphy, analysis of mitochondrial DNA (mtDNA), and flow cytometry-based analysis of mitochondria density were performed in mature 3T3-L1 adipocytes after 24 h incubation with ATRA (2 mu M) or vehicle. Selected genes linked to mitochondria biogenesis and function and mitochondria immunostaining were analyzed in WAT tissues of ATRA-treated as compared with vehicle-treated mice. ATRA upregulated the expression of a large set of genes linked to mtDNA replication and transcription, mitochondrial biogenesis, and OXPHOS in adipocytes, as indicated by transcriptome analysis. Oxygen consumption rate, mtDNA content, and staining of mitochondria were increased in the ATRA-treated adipocytes. Similar results were obtained in WAT depots of ATRA-treated mice. We conclude that ATRA impacts mitochondria in adipocytes, leading to increased OXPHOS capacity and mitochondrial content in these cells. | en |
dc.description.sponsorship | This work was supported by the Aix-Marseille Universite, INRA, and EU FP7 project DIABAT. Authors belong to the Nutrigenomics-group, awarded as Group of Excellence of the Autonomous Community of the Balearic Islands (CAIB) and supported by Direccio General d'Universitats, Recerca i Transferencia del Coneixement of Regional Government (CAIB) and FEDER funds (EU). CIBER de Fisiopatologia de la Obesidad y Nutricion is an initiative of the ISCIII (Spanish Government). H.M. was the recipient of a fellowship from the government of the CAIB. | es_ES |
dc.language.iso | eng | en |
dc.publisher | Amer Soc Biochemistry Molecular Biology Inc | en |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Vitamin A | en |
dc.subject | Adipose tissue | en |
dc.subject | Browning | en |
dc.subject.mesh | DNA, Mitochondrial | * |
dc.subject.mesh | Organelle Biogenesis | * |
dc.subject.mesh | Mitochondria | * |
dc.subject.mesh | Gene Expression Profiling | * |
dc.subject.mesh | Animals | * |
dc.subject.mesh | Adipocytes | * |
dc.subject.mesh | Gene Expression Regulation | * |
dc.subject.mesh | Oxidative Phosphorylation | * |
dc.subject.mesh | Adipose Tissue, White | * |
dc.subject.mesh | Mitochondrial Proteins | * |
dc.subject.mesh | Mice | * |
dc.subject.mesh | Tretinoin | * |
dc.title | All-trans retinoic acid induces oxidative phosphorylation and mitochondria biogenesis in adipocytes | en |
dc.type | research article | en |
dc.rights.license | Attribution 4.0 International | * |
dc.identifier.pubmedID | 25914170 | es_ES |
dc.format.volume | 56 | es_ES |
dc.format.number | 6 | es_ES |
dc.format.page | 1100-1109 | es_ES |
dc.identifier.doi | 10.1194/jlr.M053652 | |
dc.identifier.e-issn | 1539-7262 | es_ES |
dc.relation.publisherversion | https://dx.doi.org/10.1194/jlr.M053652 | en |
dc.identifier.journal | Journal of Lipid Research | es_ES |
dc.rights.accessRights | open access | en |
dc.subject.decs | Regulación de la Expresión Génica | * |
dc.subject.decs | Animales | * |
dc.subject.decs | Tretinoina | * |
dc.subject.decs | Tejido Adiposo Blanco | * |
dc.subject.decs | Adipocitos | * |
dc.subject.decs | Biogénesis de Organelos | * |
dc.subject.decs | Ratones | * |
dc.subject.decs | Perfilación de la Expresión Génica | * |
dc.subject.decs | Proteínas Mitocondriales | * |
dc.subject.decs | ADN Mitocondrial | * |
dc.subject.decs | Mitocondrias | * |
dc.subject.decs | Fosforilación Oxidativa | * |
dc.identifier.scopus | 2-s2.0-84937117244 | |
dc.identifier.wos | 355532400003 | |
dc.identifier.pui | L605202641 |
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