dc.contributor.author | Cuervo, Guillermo | |
dc.contributor.author | Camoez, Mariana | |
dc.contributor.author | Shaw, Evelyn | |
dc.contributor.author | Angeles Dominguez, Maria | |
dc.contributor.author | Gasch, Oriol | |
dc.contributor.author | Padilla, Belen | |
dc.contributor.author | Pintado, Vicente | |
dc.contributor.author | Almirante, Benito | |
dc.contributor.author | Molina, Jose | |
dc.contributor.author | Lopez-Medrano, Francisco | |
dc.contributor.author | Ruiz de Gopegui-Bordes, Enrique | |
dc.contributor.author | Martinez, Jose A | |
dc.contributor.author | Bereciartua, Elena | |
dc.contributor.author | Rodriguez-Lopez, Fernando | |
dc.contributor.author | Fernandez-Mazarrasa, Carlos | |
dc.contributor.author | Angel Goenaga, Miguel | |
dc.contributor.author | Benito, Natividad | |
dc.contributor.author | Rodriguez-Bano, Jesus | |
dc.contributor.author | Espejo, Elena | |
dc.contributor.author | Pujol, Miquel | |
dc.contributor.author | REIPI GEIH Study Grp | |
dc.date.accessioned | 2024-07-04T12:56:32Z | |
dc.date.available | 2024-07-04T12:56:32Z | |
dc.date.issued | 2015-10-30 | |
dc.identifier.citation | Cuervo G, Camoez M, Shaw E, Dominguez MA, Gasch O, Padilla B, et al. Methicillin-resistant Staphylococcus aureus (MRSA) catheter-related bacteraemia in haemodialysis patients. BMC Infect Dis. 2015 Oct 30;15:484. | en |
dc.identifier.issn | 1471-2334 | |
dc.identifier.other | http://hdl.handle.net/20.500.13003/10657 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/20155 | |
dc.description.abstract | Background: The aim of the study was to determine clinical and microbiological differences between patients with methicillin-resistant Staphylococcus aureus (MRSA) catheter-related bacteraemia (CRB) undergoing or not undergoing haemodialysis, and to compare outcomes. Methods: Prospective multicentre study conducted at 21 Spanish hospitals of patients with MRSA bacteraemia diagnosed between June 2008 and December 2009. Patients with MRSA-CRB were selected. Data of patients on haemodialysis (HD-CRB) and those not on haemodialysis (non-HD-CRB) were compared. Results: Among 579 episodes of MRSA bacteraemia, 218 (37.7 %) were CRB. Thirty-four (15.6 %) were HD-CRB and 184 (84.4 %) non-HD-CRB. All HD-CRB patients acquired the infection at dialysis centres, while in 85.3 % of the non-HD-CRB group the infection was nosocomial (p < .001). There were no differences in age, gender or severity of bacteraemia (Pitt score); comorbidities (Charlson score >= 4) were higher in the HD-CRB group than in the non-HD-CRB group (73.5 % vs. 46.2 %, p = .003). Although there were no differences in VAN-MIC >= 1.5 mg/L according to microdilution, using the E-test a higher rate of VAN-MIC >= 1.5 mg/L was observed in HD-CRB than in non-HD-CRB patients (63.3 % vs. 44.1 %, p = .051). Vancomycin was more frequently administered in the HD-CRB group than in the non-HD-CRB group (82.3 % vs. 42.4 %, p = <. 001) and therefore the appropriate empirical therapy was significantly higher in HD-CRB group (91.2 % vs. 73.9 %, p = .029). There were no differences with regard to catheter removal (79.4 % vs. 84.2 %, p = .555, respectively). No significant differences in mortality rate were observed between both groups (Overall mortality: 11.8 % vs. 27.2 %, p = .081, respectively), but there was a trend towards a higher recurrence rate in HD-CRB group (8.8 % vs. 2.2 %, p = .076). Conclusions: In our multicentre study, ambulatory patients in chronic haemodialysis represented a significant proportion of cases of MRSA catheter-related bacteraemia. Although haemodialysis patients with MRSA catheter-related bacteraemia had significantly more comorbidities and higher proportion of strains with reduced vancomycin susceptibility than non-haemodialysis patients, overall mortality between both groups was similar. | en |
dc.description.sponsorship | This study was supported by Ministerio de Ciencia e Innovacion, Instituto de Salud Carlos III (FIS 08/0335) and co-financed by the European Development Regional Fund 'A way to achieve Europe' ERDF, Spanish Network for Research in Infectious Diseases (REIPI RD06/0008).; O. G. was recipient of a Rio Hortega Grant (CM08/228) from the Instituto de Salud Carlos III. | es_ES |
dc.language.iso | eng | en |
dc.publisher | BioMed Central (BMC) | en |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Bacteraemia | en |
dc.subject | Catheter-related | en |
dc.subject | Haemodialysis | en |
dc.subject | MRSA | en |
dc.subject.mesh | Bacteremia | * |
dc.subject.mesh | Aged | * |
dc.subject.mesh | Spain | * |
dc.subject.mesh | Anti-Bacterial Agents | * |
dc.subject.mesh | Cross Infection | * |
dc.subject.mesh | Humans | * |
dc.subject.mesh | Renal Dialysis | * |
dc.subject.mesh | Middle Aged | * |
dc.subject.mesh | Male | * |
dc.subject.mesh | Prospective Studies | * |
dc.subject.mesh | Female | * |
dc.subject.mesh | Methicillin-Resistant Staphylococcus aureus | * |
dc.subject.mesh | Treatment Outcome | * |
dc.subject.mesh | Vancomycin | * |
dc.subject.mesh | Catheter-Related Infections | * |
dc.subject.mesh | Comorbidity | * |
dc.subject.mesh | Staphylococcal Infections | * |
dc.title | Methicillin-resistant Staphylococcus aureus (MRSA) catheter-related bacteraemia in haemodialysis patients | en |
dc.type | research article | en |
dc.rights.license | Attribution 4.0 International | * |
dc.identifier.pubmedID | 26518487 | es_ES |
dc.format.volume | 15 | es_ES |
dc.format.page | 484 | es_ES |
dc.identifier.doi | 10.1186/s12879-015-1227-y | |
dc.relation.publisherversion | https://dx.doi.org/10.1186/s12879-015-1227-y | en |
dc.identifier.journal | BMC Infectious Diseases | es_ES |
dc.rights.accessRights | open access | en |
dc.subject.decs | Resultado del Tratamiento | * |
dc.subject.decs | Vancomicina | * |
dc.subject.decs | Comorbilidad | * |
dc.subject.decs | Infecciones Estafilocócicas | * |
dc.subject.decs | Femenino | * |
dc.subject.decs | Masculino | * |
dc.subject.decs | Diálisis Renal | * |
dc.subject.decs | Staphylococcus aureus Resistente a Meticilina | * |
dc.subject.decs | Humanos | * |
dc.subject.decs | Persona de Mediana Edad | * |
dc.subject.decs | Estudios Prospectivos | * |
dc.subject.decs | Anciano | * |
dc.subject.decs | Infección Hospitalaria | * |
dc.subject.decs | Bacteriemia | * |
dc.subject.decs | Antibacterianos | * |
dc.subject.decs | Infecciones Relacionadas con Catéteres | * |
dc.subject.decs | España | * |
dc.identifier.scopus | 2-s2.0-84945907463 | |
dc.identifier.wos | 364278200001 | |
dc.identifier.pui | L606719322 | |