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dc.contributor.author | Valvi, Damaskini | |
dc.contributor.author | Casas, Maribel | |
dc.contributor.author | Romaguera, Dora | |
dc.contributor.author | Monfort, Nuria | |
dc.contributor.author | Ventura, Rosa | |
dc.contributor.author | Martinez, David | |
dc.contributor.author | Sunyer, Jordi | |
dc.contributor.author | Vrijheid, Martine | |
dc.date.accessioned | 2024-07-04T12:56:28Z | |
dc.date.available | 2024-07-04T12:56:28Z | |
dc.date.issued | 2015-10 | |
dc.identifier.citation | Valvi D, Casas M, Romaguera D, Monfort N, Ventura R, Martinez D, et al. Prenatal Phthalate Exposure and Childhood Growth and Blood Pressure: Evidence from the Spanish INMA-Sabadell Birth Cohort Study. Environ Health Perspect. 2015 Oct;123(10):1022-9. Epub 2015 Apr 7. | en |
dc.identifier.issn | 0091-6765 | |
dc.identifier.other | http://hdl.handle.net/20.500.13003/10682 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/20146 | |
dc.description.abstract | BACKGROUND: Human evidence on the effects of early life phthalate exposure on obesity and cardiovascular disease risks, reported by experimental studies, is limited to a few cross-sectional studies. OBJECTIVES: We evaluated the associations between prenatal phthalate exposure and childhood growth and blood pressure in a Spanish birth cohort study. METHODS: We assessed exposure using the average of two phthalate metabolite spot-urine concentrations collected from the mothers in the first and third pregnancy trimesters (creatinine-adjusted, n = 391). Study outcomes were the difference in age-and sex-specific z-scores for weight between birth and 6 months of age; and repeated age-and sex-specific z-scores for body mass index (BMI) at 1, 4, and 7 years; waist-to-height ratio at 4 and 7 years; and age-and height-specific z-scores for systolic and diastolic blood pressure at 4 and 7 years. RESULTS: The sum of five high-molecular-weight phthalate metabolites (Sigma HMWPm) was associated with lower weight z-score difference between birth and 6 months (beta per doubling of exposure = -0.41; 95% CI: -0.75, -0.06) and BMI z-scores at later ages in boys (beta = -0.28; 95% CI: -0.60, 0.03) and with higher weight z-score difference (beta = 0.24; 95% CI: -0.16, 0.65) and BMI z-scores in girls (beta = 0.30; 95% CI: -0.04, 0.64) (p for sex interaction = 0.01 and 0.05, respectively). The sum of three low-molecular-weight phthalates (Sigma LMWPm) was not significantly associated with any of the growth outcomes. Sigma HMWPm and Sigma LMWPm were associated with lower systolic blood pressure z-scores in girls but not in boys. CONCLUSIONS: This study suggests that prenatal phthalate exposure may be associated with postnatal growth and blood pressure in a sex-specific manner. Inconsistencies with previous cross-sectional findings highlight the necessity for evaluating phthalate health effects in prospective studies. | en |
dc.description.sponsorship | This study was funded by grants from the RecerCaixa (Register no. 2010ACUP00349), the Instituto Carlos III (Red INMA G03/176, CB06/02/0041 and predoctoral grant PFIS 2010, Register no. FI10/00399), the Spanish Ministry of Health (FIS-PI041436, FIS-PI081151), the Generalitat de Catalunya-CIRIT (1999SGR 00241), and the Fundacio Roger Torne. A full roster of the INMA Project investigators can be found at http://www.proyectoinma.org. | es_ES |
dc.language.iso | eng | en |
dc.publisher | Us Dept Health Human Sciences Public Health Science | en |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject.mesh | Child | * |
dc.subject.mesh | Spain | * |
dc.subject.mesh | Adult | * |
dc.subject.mesh | Environmental Pollutants | * |
dc.subject.mesh | Humans | * |
dc.subject.mesh | Child, Preschool | * |
dc.subject.mesh | Blood Pressure | * |
dc.subject.mesh | Infant | * |
dc.subject.mesh | Pregnancy | * |
dc.subject.mesh | Phthalic Acids | * |
dc.subject.mesh | Waist-Height Ratio | * |
dc.subject.mesh | Male | * |
dc.subject.mesh | Infant, Newborn | * |
dc.subject.mesh | Prospective Studies | * |
dc.subject.mesh | Sex Factors | * |
dc.subject.mesh | Female | * |
dc.subject.mesh | Body Mass Index | * |
dc.subject.mesh | Weight Gain | * |
dc.subject.mesh | Prenatal Exposure Delayed Effects | * |
dc.title | Prenatal Phthalate Exposure and Childhood Growth and Blood Pressure: Evidence from the Spanish INMA-Sabadell Birth Cohort Study | en |
dc.type | research article | en |
dc.rights.license | Attribution 4.0 International | * |
dc.identifier.pubmedID | 25850106 | es_ES |
dc.format.volume | 123 | es_ES |
dc.format.number | 10 | es_ES |
dc.format.page | 1022-1029 | es_ES |
dc.identifier.doi | 10.1289/ehp.1408887 | |
dc.identifier.e-issn | 1552-9924 | es_ES |
dc.relation.publisherversion | https://dx.doi.org/10.1289/ehp.1408887 | en |
dc.identifier.journal | Environmental Health Perspectives | es_ES |
dc.rights.accessRights | open access | en |
dc.subject.decs | Índice de Masa Corporal | * |
dc.subject.decs | Aumento de Peso | * |
dc.subject.decs | Recién Nacido | * |
dc.subject.decs | Femenino | * |
dc.subject.decs | Lactante | * |
dc.subject.decs | Masculino | * |
dc.subject.decs | Contaminantes Ambientales | * |
dc.subject.decs | Factores Sexuales | * |
dc.subject.decs | Preescolar | * |
dc.subject.decs | Presin Sanguínea | * |
dc.subject.decs | Humanos | * |
dc.subject.decs | Relación Cintura-Estatura | * |
dc.subject.decs | Estudios Prospectivos | * |
dc.subject.decs | Embarazo | * |
dc.subject.decs | Ácidos Ftálicos | * |
dc.subject.decs | Niño | * |
dc.subject.decs | Adulto | * |
dc.subject.decs | Efectos Tardíos de la Exposición Prenatal | * |
dc.subject.decs | España | * |
dc.identifier.scopus | 2-s2.0-84930638624 | |
dc.identifier.wos | 366698200024 | |
dc.identifier.pui | L606301160 |
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