dc.contributor.author | Sanada, Kenji | |
dc.contributor.author | Alda Diez, Marta | |
dc.contributor.author | Salas Valero, Montserrat | |
dc.contributor.author | Perez-Yus, Maria Cruz | |
dc.contributor.author | Demarzo, Marcelo | |
dc.contributor.author | Garcia Toro, Mauro | |
dc.contributor.author | Garcia-Campayo, Javier | |
dc.date.accessioned | 2024-07-04T12:56:27Z | |
dc.date.available | 2024-07-04T12:56:27Z | |
dc.date.issued | 2015-09-26 | |
dc.identifier.citation | Sanada K, Diez Marta A, Salas Valero M, Cruz Perez-Yus M, Demarzo MMP, Garcia Toro M, et al. Effects of non-pharmacological interventions on inflammatory biomarker expression in patients with fibromyalgia: a systematic review. Arthritis Res Ther. 2015 Sep 26;17:272. | en |
dc.identifier.issn | 1478-6354 | |
dc.identifier.other | http://hdl.handle.net/20.500.13003/10692 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/20145 | |
dc.description.abstract | Introduction: Fibromyalgia (FM) is a prevalent disorder. However, few studies have evaluated the effect of treatment interventions on biomarker expression. The aim of this review was to explore the efficacy of non-pharmacological interventions on inflammatory biomarker expression, specifically cytokines, neuropeptides and C-reactive protein (CRP), in FM patients. Method: A literature search using PubMed, EMBASE, PsycINFO and the Cochrane library was performed from January 1990 to March 2015. Randomized controlled trials (RCTs) and non-RCTs published in English, French or Spanish were eligible. Results: Twelve articles with a total of 536 participants were included. After exercise, multidisciplinary, or dietary interventions in FM patients, interleukin (IL) expression appeared reduced, specifically serum IL-8 and IL-6 (spontaneous, lipopolysaccharide (LPS)-induced, or serum). Furthermore, the changes to insulin-like growth factor 1 (IGF-1) levels might indicate a beneficial role for fatigue in obese FM patients. In contrast, evidence of changes in neuropeptide and CRP levels seemed inconsistent. Conclusion: Despite minimal evidence, our findings indicate that exercise interventions might act as an anti-inflammatory treatment in FM patients and ameliorate inflammatory status, especially for pro-inflammatory cytokines. Additional RCTs focused on the changes to inflammatory biomarker expression after non-pharmacological interventions in FM patients are needed. | en |
dc.description.sponsorship | We thank Red de Investigacion en Actividades de Prevencion y Promocion de la Salud (Research Network on Preventative Activities and Health Promotion) (REDIAPP-G06-170 and RD06/0018/0017) and Red de Excelencia PROMOSAM (PSI2014-56303-REDT), for its support in the development of this study. | es_ES |
dc.language.iso | eng | en |
dc.publisher | BioMed Central (BMC) | en |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject.mesh | Biomarkers | * |
dc.subject.mesh | Cytokines | * |
dc.subject.mesh | Exercise Therapy | * |
dc.subject.mesh | Humans | * |
dc.subject.mesh | C-Reactive Protein | * |
dc.subject.mesh | Fibromyalgia | * |
dc.subject.mesh | Neuropeptides | * |
dc.subject.mesh | Reproducibility of Results | * |
dc.subject.mesh | Diet Therapy | * |
dc.title | Effects of non-pharmacological interventions on inflammatory biomarker expression in patients with fibromyalgia: a systematic review | en |
dc.type | research article | en |
dc.rights.license | Attribution 4.0 International | * |
dc.identifier.pubmedID | 26411586 | es_ES |
dc.format.volume | 17 | es_ES |
dc.format.page | 272 | es_ES |
dc.identifier.doi | 10.1186/s13075-015-0789-9 | |
dc.identifier.e-issn | 1478-6362 | es_ES |
dc.relation.publisherversion | https://dx.doi.org/10.1186/s13075-015-0789-9 | en |
dc.identifier.journal | Arthritis Research & Therapy | es_ES |
dc.rights.accessRights | open access | en |
dc.subject.decs | Fibromialgia | * |
dc.subject.decs | Dietoterapia | * |
dc.subject.decs | Terapia por Ejercicio | * |
dc.subject.decs | Humanos | * |
dc.subject.decs | Neuropéptidos | * |
dc.subject.decs | Reproducibilidad de los Resultados | * |
dc.subject.decs | Biomarcadores | * |
dc.subject.decs | Citocinas | * |
dc.subject.decs | Proteína C-Reactiva | * |
dc.identifier.scopus | 2-s2.0-84942312129 | |
dc.identifier.wos | 361799200001 | |
dc.identifier.pui | L606142877 | |