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dc.contributor.author | Cosmo, Camila | |
dc.contributor.author | Baptista, Abrahao Fontes | |
dc.contributor.author | de Araujo, Arao Nogueira | |
dc.contributor.author | do Rosario, Raphael Silva | |
dc.contributor.author | Vivas Miranda, Jose Garcia | |
dc.contributor.author | Montoya, Pedro | |
dc.contributor.author | de Sena, Eduardo Ponde | |
dc.date.accessioned | 2024-07-04T12:56:22Z | |
dc.date.available | 2024-07-04T12:56:22Z | |
dc.date.issued | 2015-08-12 | |
dc.identifier.citation | Cosmo C, Baptista Abrahao F, De Araujo Arao N, Do Rosario RS, Vivas Miranda JG, Montoya P, et al. A Randomized, Double-Blind, Sham-Controlled Trial of Transcranial Direct Current Stimulation in Attention-Deficit/Hyperactivity Disorder. PLoS One. 2015 Aug 12;10(8):e0135371. | en |
dc.identifier.issn | 1932-6203 | |
dc.identifier.other | http://hdl.handle.net/20.500.13003/10752 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/20132 | |
dc.description.abstract | Background: Current standardized treatments for cognitive impairment in attention-deficit/hyperactivity disorder remain limited and their efficacy restricted. Transcranial direct current stimulation (tDCS) is a promising tool for enhancing cognitive performance in several neuropsychiatric disorders. Nevertheless, the effects of tDCS in reducing cognitive impairment in patients with attention-deficit/hyperactivity disorder (ADHD) have not yet been investigated. Methods: A parallel, randomized, double-blind, sham-controlled trial was conducted to examine the efficacy of tDCS on the modulation of inhibitory control in adults with ADHD. Thirty patients were randomly allocated to each group and performed a go/no-go task before and after a single session of either anodal stimulation (1 mA) over the left dorsolateral prefrontal cortex or sham stimulation. Results: A nonparametric two-sample Wilcoxon rank-sum (Mann-Whitney) test revealed no significant differences between the two groups of individuals with ADHD (tDCS vs. sham) in regard to behavioral performance in the go/no go tasks. Furthermore, the effect sizes of group differences after treatment for the primary outcome measures-correct responses, impulsivity and omission errors-were small. No adverse events resulting from stimulation were reported. Conclusion: According to these findings, there is no evidence in support of the use of anodal stimulation over the left dorsolateral prefrontal cortex as an approach for improving inhibitory control in ADHD patients. To the best of our knowledge, this is the first clinical study to assess the cognitive effects of tDCS in individuals with ADHD. Further research is needed to assess the clinical efficacy of tDCS in this population. | en |
dc.description.sponsorship | The authors received no specific funding for this trial. CC and PM received scholarship from CAPES/Brazil. | es_ES |
dc.language.iso | eng | en |
dc.publisher | Public Library of Science (PLOS) | en |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject.mesh | Male | * |
dc.subject.mesh | Prefrontal Cortex | * |
dc.subject.mesh | Transcranial Direct Current Stimulation | * |
dc.subject.mesh | Adult | * |
dc.subject.mesh | Female | * |
dc.subject.mesh | Humans | * |
dc.subject.mesh | Attention Deficit Disorder with Hyperactivity | * |
dc.subject.mesh | Middle Aged | * |
dc.subject.mesh | Double-Blind Method | * |
dc.title | A Randomized, Double-Blind, Sham-Controlled Trial of Transcranial Direct Current Stimulation in Attention-Deficit/Hyperactivity Disorder | en |
dc.type | research article | en |
dc.rights.license | Attribution 4.0 International | * |
dc.identifier.pubmedID | 26267861 | es_ES |
dc.format.volume | 10 | es_ES |
dc.format.number | 8 | es_ES |
dc.format.page | e0135371 | es_ES |
dc.identifier.doi | 10.1371/journal.pone.0135371 | |
dc.relation.publisherversion | https://dx.doi.org/10.1371/journal.pone.0135371 | en |
dc.identifier.journal | PloS One | es_ES |
dc.rights.accessRights | open access | en |
dc.subject.decs | Método Doble Ciego | * |
dc.subject.decs | Estimulación Transcraneal de Corriente Directa | * |
dc.subject.decs | Trastorno por Déficit de Atención con Hiperactividad | * |
dc.subject.decs | Humanos | * |
dc.subject.decs | Persona de Mediana Edad | * |
dc.subject.decs | Femenino | * |
dc.subject.decs | Adulto | * |
dc.subject.decs | Corteza Prefrontal | * |
dc.subject.decs | Masculino | * |
dc.identifier.scopus | 2-s2.0-84942945230 | |
dc.identifier.wos | 359492300108 | |
dc.identifier.pui | L606195682 |
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