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dc.contributor.author | Cosmo, Camila | |
dc.contributor.author | Ferreira, Candida | |
dc.contributor.author | Garcia, Jose | |
dc.contributor.author | Miranda, Vivas | |
dc.contributor.author | do Rosario, Raphael Silva | |
dc.contributor.author | Baptista, Abrahao Fontes | |
dc.contributor.author | Montoya, Pedro | |
dc.contributor.author | de Sena, Eduardo Ponde | |
dc.date.accessioned | 2024-07-04T12:56:21Z | |
dc.date.available | 2024-07-04T12:56:21Z | |
dc.date.issued | 2015-08-04 | |
dc.identifier.citation | Cosmo C, Ferreira C, Garcia J, Vivas M, Do Rosario RS, Fontes Baptista A, et al. Spreading effect of tDCS in individuals with attention-deficit/hyperactivity disorder as shown by functional cortical networks: a randomized, double-blind, sham-controlled trial. Front Psychiatry. 2015 Aug 04;6:111. | en |
dc.identifier.issn | 1664-0640 | |
dc.identifier.other | http://hdl.handle.net/20.500.13003/10756 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/20130 | |
dc.description.abstract | Background: Transcranial direct current stimulation (tDCS) is known to modulate spontaneous neural network excitability. The cognitive improvement observed in previous trials raises the potential of this technique as a possible therapeutic tool for use in attentiondeficit/hyperactivity disorder (ADHD) population. However, to explore the potential of this technique as a treatment approach, the functional parameters of brain connectivity and the extent of its effects need to be more fully investigated. Objective: The aim of this study was to investigate a functional cortical network (FCN) model based on electroencephalographic activity for studying the dynamic patterns of brain connectivity modulated by tDCS and the distribution of its effects in individuals with ADHD. Methods: Sixty ADHD patients participated in a parallel, randomized, double-blind, sham-controlled trial. Individuals underwent a single session of sham or anodal tDCS at 1 mA of current intensity over the left dorsolateral prefrontal cortex for 20 min. The acute effects of stimulation on brain connectivity were assessed using the FCN model based on electroencephalography activity. Results: Comparing the weighted node degree within groups prior to and following the intervention, a statistically significant difference was found in the electrodes located on the target and correlated areas in the active group (p <0.05), while no statistically significant results were found in the sham group (p > 0.05; paired-sample Wilcoxon signed-rank test). Conclusion: Anodal tDCS increased functional brain connectivity in individuals with ADHD compared to data recorded in the baseline resting state. In addition, although some studies have suggested that the effects of tDCS are selective, the present findings show that its modulatory activity spreads. Further studies need to be performed to investigate the dynamic patterns and physiological mechanisms underlying the modulatory effects of tDCS. | en |
dc.description.sponsorship | The authors are grateful to Professor Carlos Teles, Ph.D., who performed the randomization procedure and developed the allocation concealment approach for this trial. CC received a scholarship (BEX 12253-12-0) from the Coordination for the Improvement of Higher Education Personnel (CAPES), Brazilian Ministry of Education. PM received a scholarship (CAPES/CNPq 2947/2013) from CAPES and the Council for Scientific and Technological Development (CNPq), Brazilian Ministry of Education. JM also received a grant from CNPq 306998/2014-9. | es_ES |
dc.language.iso | eng | en |
dc.publisher | Frontiers Media | en |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Attention-deficit/hyperactivity disorder | en |
dc.subject | Functional cortical networks | en |
dc.subject | Transcranial direct current stimulation | en |
dc.subject | Spreading effect | en |
dc.subject | Dorsolateral prefrontal cortex | en |
dc.title | Spreading effect of tDCS in individuals with attention-deficit/hyperactivity disorder as shown by functional cortical networks: a randomized, double-blind, sham-controlled trial | en |
dc.type | research article | en |
dc.rights.license | Attribution 4.0 International | * |
dc.identifier.pubmedID | 26300790 | es_ES |
dc.format.volume | 6 | es_ES |
dc.format.page | 111 | es_ES |
dc.identifier.doi | 10.3389/fpsyt.2015.00111 | |
dc.relation.publisherversion | https://dx.doi.org/10.3389/fpsyt.2015.00111 | en |
dc.identifier.journal | Frontiers in Psychiatry | es_ES |
dc.rights.accessRights | open access | en |
dc.identifier.scopus | 2-s2.0-84940565363 | |
dc.identifier.wos | 364470800002 | |
dc.identifier.pui | L605834486 |
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